Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers DOI

Hai Xu,

Songsong Ding,

Tong Yu

et al.

Biological Research For Nursing, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Background: Obese patients are increasingly recognized as being at higher risk for skin diseases, particularly chronic wounds. While the exact mechanisms remain unclear, obesity is suspected to influence development of injuries via inflammatory biomarkers. Single nucleotide polymorphisms (SNPs) may further gene expression, protein function, and levels biomarkers through various mechanisms, thereby modulating responses that contribute wound pathogenesis. Methods: A two-sample two-step Mendelian Randomization (MR) was employed explore causal relationship between wounds, focusing on mediating role SNPs were used instrumental variables (IVs) infer causality. Obesity-related genetic data sourced from UK Biobank GIANT consortium. Genome-wide association studies provided 92 biomarkers, involving 14,824 575,531 individuals. Pressure injuries, lower limb venous ulcers, diabetic foot ulcer obtained FinnGen R10 Pan-UK Biobank. Results: Obesity significantly increased pressure ulcers. CCL19, hGDNF, IL-12B, TNFRSF9 identified mediators in obesity-induced Conclusion: This study provides evidence leads ulcers suggesting potential therapeutic targets intervention.

Language: Английский

Metformin’s Effects on Cognitive Function from a Biovariance Perspective: A Narrative Review DOI Open Access

Dimitrie Chele,

Carmen Adella Sîrbu,

Marian Mitrică

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1783 - 1783

Published: Feb. 19, 2025

This study examines the effects of metformin on brain functions focusing variability results reported in literature. While some studies suggest that may have neuroprotective diabetic patients, others report an insignificant impact cognitive function, or even a negative effect. We propose this inconsistency be due to intrinsic cellular-level among individuals, which we term "biovariance". Biovariance persists demographically homogeneous samples complex and stochastic biological processes. Additionally, metabolic actions metformin, including its influence neuroenergetics neuronal survival, produce different depending individual characteristics.

Language: Английский

Citations

1
Dysregulation of Metabolic Peptides in the Gut–Brain Axis Promotes Hyperinsulinemia, Obesity, and Neurodegeneration DOI Creative Commons

Camille Green,

Vandana Zaman,

Kayce Blumenstock

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 132 - 132

Published: Jan. 8, 2025

Metabolic peptides can influence metabolic processes and contribute to both inflammatory and/or anti-inflammatory responses. Studies have shown that there are thousands of peptides, made up short chains amino acids, the human body produces. These crucial for regulating many different like metabolism cell signaling, as they bind receptors on various cells. This review will cover role three specific their roles in hyperinsulinemia, diabetes, inflammation, neurodegeneration, well type 3 diabetes dementia. The glucagon-like peptide 1 (GLP-1), gastric inhibitor polypeptide (GIP), pancreatic (PP) be discussed, dysregulation within lead development neurodegenerative diseases. Research has been able closely investigate connections between these links gut–brain axis, highlighting changes gut dysfunction brain, brain gut. potentially reversal diseases such obesity, 2 also discussed. Furthermore, we potential conditions neuroinflammation dementia, specifically Parkinson’s disease Alzheimer’s disease.

Language: Английский

Citations

0
Vagotomy suppresses food intake by increasing GLP-1 secretion via the M3 AChR-AMPKα pathway in mice DOI
Jie Lin, Yikai Shen,

Yiwen Xia

et al.

Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112464 - 112464

Published: Jan. 1, 2025

Language: Английский

Citations

0
A 2-Years Comparative Analysis of Tirzepatide, Semaglutide, Qsymia, Contrave, and Phentermine on Ocular Health in Individuals with Obesity: A Propensity-Score Matched Cohort Study DOI Creative Commons
Pen‐Hua Su, Yu‐Nan Huang,

Jo-Ching Chen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract This landmark propensity-score matched study examined ocular outcomes of modern anti-obesity medications in nearly 5 million non-diabetic individuals with obesity. Through analysis TriNetX US network data, we discovered that Tirzepatide significantly reduced cataract risk versus other treatments, showing a striking 59% lower compared to Semaglutide (HR: 0.41, 95% CI: 0.19–0.85). users experienced markedly fewer visual disturbances than those on Contrave 0.58, 0.41–0.82) or Phentermine 0.62, 0.46–0.82). Both GLP-1 receptor agonists demonstrated protection against age-related cataracts, exceptional benefits 0.17, 0.07–0.42). While these protective effects remained robust across patient subgroups, Tirzepatide's diminished impaired kidney function. Multiple sensitivity analyses and negative controls validated compelling findings.

Language: Английский

Citations

0
Comparative Effectiveness of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Preventing Alzheimer's Disease, Vascular Dementia, and Other Dementia Types Among Patients with Type 2 Diabetes DOI
Mingyang Sun, Xiaoling Wang, Zhongyuan Lu

et al.

Diabetes & Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 101623 - 101623

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advances in energy balance & metabolism circuitry DOI
José G. Grajales-Reyes

Advances in genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Aging, vascular dysfunction, and the blood–brain barrier: unveiling the pathophysiology of stroke in older adults DOI
Saleh I. Alaqel, Mohd Imran,

Abida Khan

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 5, 2025

Language: Английский

Citations

0
Glucagon-like peptide-1 receptor agonists for major neurocognitive disorders DOI
Riccardo De Giorgi, Ana Ghenciulescu,

Courtney Yotter

et al.

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. jnnp - 335593

Published: April 10, 2025

Disease-modifying treatments for major neurocognitive disorders, including Alzheimer’s disease, Parkinson’s disease and other cognitive deficits, are among the main unmet needs in modern medicine. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), currently licensed treatment of type 2 diabetes mellitus obesity, offer a novel, multilayered mechanism intervention neurodegeneration through intermediate, aetiology-agnostic pathways, likely involving metabolic, inflammatory several relevant neurobiological processes. In vitro animal studies have revealed promising signals neuroprotection, with preliminary supportive evidence emerging from recent pharmacoepidemiological investigations clinical trials. this article, we comprehensively review that investigate impact GLP-1RAs on various aetiologies impairment dementia syndromes. Focusing human studies, highlight how brain energy homeostasis, neurogenesis, synaptic functioning, neuroinflammation cellular stress responses, pathological protein aggregates, proteostasis, cerebrovascular system blood-brain barrier dynamics may underlie GLP-1RA putative neuroprotective effects. We then report appraise observational investigations, trials pooled analyses. Finally, discuss current challenges perspectives ahead research implementation care people their individual penetrance potential, need response biomarkers stage-based indications, possible non-specific effects health, profile terms adverse events unwanted effects, lack long-term data efficacy safety, issues surrounding cost availability treatment.

Language: Английский

Citations

0
Structural pharmacology and mechanisms of GLP-1R signaling DOI
Qingtong Zhou,

Fenghui Zhao,

Y Zhang

et al.

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers DOI

Hai Xu,

Songsong Ding,

Tong Yu

et al.

Biological Research For Nursing, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Background: Obese patients are increasingly recognized as being at higher risk for skin diseases, particularly chronic wounds. While the exact mechanisms remain unclear, obesity is suspected to influence development of injuries via inflammatory biomarkers. Single nucleotide polymorphisms (SNPs) may further gene expression, protein function, and levels biomarkers through various mechanisms, thereby modulating responses that contribute wound pathogenesis. Methods: A two-sample two-step Mendelian Randomization (MR) was employed explore causal relationship between wounds, focusing on mediating role SNPs were used instrumental variables (IVs) infer causality. Obesity-related genetic data sourced from UK Biobank GIANT consortium. Genome-wide association studies provided 92 biomarkers, involving 14,824 575,531 individuals. Pressure injuries, lower limb venous ulcers, diabetic foot ulcer obtained FinnGen R10 Pan-UK Biobank. Results: Obesity significantly increased pressure ulcers. CCL19, hGDNF, IL-12B, TNFRSF9 identified mediators in obesity-induced Conclusion: This study provides evidence leads ulcers suggesting potential therapeutic targets intervention.

Language: Английский

Citations

1