New hope for the world cancer day

Biology Direct, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 4, 2025

Language: Английский

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Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Cancer immunotherapy, which leverages the body's immune system to combat cancer, offers promise of lower toxicity and higher therapeutic efficacy compared conventional treatments. However, current immunotherapeutic approaches face significant challenges including variable patient response, immune‐related adverse events, high costs, underscoring urgent need for innovative strategies. Metal‐based nanomaterials have emerged as a promising avenue in cancer immunotherapy due their unique physicochemical properties immune‐regulating capabilities. Despite potential, concerns about toxicity, incomplete understanding modulation mechanisms, early‐stage design strategies hinder clinical translation. This review summarizes recent advancements metal‐based elucidates mechanisms by they enhance antitumor immunity responses, explores potential synergistic effects combining multiple metals. We also discuss key future perspectives application, aiming provide theoretical foundation development immunotherapies promote broader application treatment.

Language: Английский

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Metabolic Reallocation in the Tumor Microenvironment of Colorectal Cancer at Single-cell Resolution

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Metabolic reprogramming of diverse cell types within the tumor microenvironment (TME) is crucial for progression. While previous single-cell studies have identified a set up- or down-regulated pathways, they often overlook broader question how metabolic activity dynamically allocated among competing processes. Here we present computational framework integrating multiple transcriptomic datasets human colorectal cancer (CRC) to quantify resource allocation strategies in TME. Our analysis revealed cell-type-specific reallocation occurring at both global and local levels mode regulation by novel signaling modules, regulators (MRRs), that occur specifically cells, suggesting complex network signaling-metabolism crosstalk during Activities these MRRs are significantly associated with biological clinical features tumors, highlighting critical role By characterizing plasticity TME its regulatory drivers, this study advances our understanding CRC metabolism offers insights into precision medicine targeting dependencies.

Language: Английский

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Microglial Fructose Metabolism Is Essential for Glioblastoma Growth

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Glioblastoma (GBM) is most common and aggressive primary brain tumor in adults, for which standard of care hasn’t changed twenty years. GBM associated macrophages (TAMCs), consisting infiltrating myeloid cells from the periphery resident microglia cells, are pro-tumorigenic, promoting growth. Fructose one abundant metabolites microenvironment (TME), as well healthy central nervous system (CNS). In CNS GBM, predominant expressors fructose transporter GLUT5. Mice lacking GLUT5 (GLUT5-KO) survive significantly longer after orthotopic implantation two glioma cell lines than wildtype mice, not due to dietary or peripherally derived TAMCs. Investigation TME showed that GLUT5-KO mice have more highly activated inflammatory innate adaptive immune compartments. Microglia cultured a decreased phagocytic ability exhibit capacity polyol pathway redox homeostasis.

Language: Английский

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Updated insights into the molecular networks for NLRP3 inflammasome activation

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Over the past decade, significant advances have been made in our understanding of how NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasomes are activated. These findings provide detailed insights into transcriptional posttranslational regulatory processes, structural-functional relationship activation spatiotemporal dynamics NLRP3 activation. Notably, multifaceted mechanisms underlying licensing inflammasome constitute a focal point intense research. Extensive research has revealed interactions its components with partner molecules terms positive negative regulation. In this Review, we current complex molecular networks that play pivotal roles regulating priming, assembly. addition, highlight intricate interconnected involved associated pathways. Furthermore, discuss recent development therapeutic strategies targeting to identify potential therapeutics for NLRP3-associated inflammatory diseases. As continues uncover intricacies governing activation, novel approaches interventions against NLRP3-related pathologies emerging.

Language: Английский

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AKR1B1 Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(10)

Published: May 1, 2025

ABSTRACT Background AKR1B1, a member of the aldo‐keto reductase enzyme family involved in polyol pathway aldehyde metabolism, is aberrantly expressed colorectal cancer (CRC). Our previous studies demonstrated that AKR1B1 knockdown reduced motility and proliferation CRC cell lines, its elevated expression was correlated with increased mesenchymal marker expression, inflammation, poor prognosis patient cohorts. However, whether stromal cells also express can affect clinical outcomes has not been examined. Objectives To evaluate within tumor microenvironment (TME) CRC, paticular focus on cells, to assess association outcomes. Methods We assessed tumors utilizing publicly available transcriptomic data from tumors. Single‐cell RNA‐sequencing samples were analyzed determine type‐specific expression. Immunohistochemistry based assessment performed Turkish Serbian Co‐localization CD163 (M2 macrophage marker) evaluated by immunoflourescence. Results both epithelial components tumors, higher observed stroma. analysis revealed myeloid T NK B dendritic fibroblasts, cells. Notably, AKR1B1‐expressing macrophages predominantly M2 phenotype, showed strong positive correlation bulk data. Immunofluorescence confirmed colocalization macrophages. Moreover, immunohistochemical stroma cohort patients associated favorable overall survival, particularly infiltration. Conclusions Overall, our findings underscore significant influence TME composition relationship between

Language: Английский

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The polarizing nature of fructose

Science Signaling, Journal Year: 2024, Volume and Issue: 17(866)

Published: Dec. 10, 2024

Dietary fructose skews tumor-associated macrophages toward a pro-cancer phenotype in colorectal tumors.

Language: Английский

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