Adipose Tissue as a Major Launch Spot for Circulating Extracellular Vesicle-Carried MicroRNAs Coordinating Tissue and Systemic Metabolism DOI Open Access

Paula Diez-Roda,

Esther Pérez‐Navarro, Rubén García-Martín

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13488 - 13488

Published: Dec. 17, 2024

Circulating microRNAs (miRNAs), especially transported by extracellular vesicles (EVs), have recently emerged as major new participants in interorgan communication, playing an important role the metabolic coordination of our tissues. Among these, adipose tissue displays extraordinary ability to secrete a vast list EV-carried miRNAs into circulation, representing hormone-like factors. Despite limitations current methodologies for unequivocal identification origin and destination vivo, recent investigations clearly support regulatory adipose-derived circulating shaping metabolism function other tissues including liver, muscle, endocrine pancreas, cardiovascular system, gastrointestinal tract, brain. Here, we review most findings regarding EVs (AdEVs) targeting organs implications this dialog physiology pathology. We also here potential future diagnostic therapeutic applications AdEV-carried miRNAs.

Language: Английский

Glucose-dependent insulinotropic polypeptide (GIP) DOI Creative Commons
Timo D. Müller, Alice E. Adriaenssens,

Bo Ahrén

et al.

Molecular Metabolism, Journal Year: 2025, Volume and Issue: 95, P. 102118 - 102118

Published: Feb. 28, 2025

Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin identified and plays an essential role in maintenance of glucose tolerance healthy humans. Until recently GIP had not been developed as a therapeutic thus has overshadowed by other incretin, glucagon-like peptide 1 (GLP-1), which is basis for several successful drugs to treat diabetes obesity. However, there rekindling interest biology recent years, great part due pharmacology demonstrating that both GIPR agonism antagonism may be beneficial treating obesity diabetes. This apparent paradox reinvigorated field, led new lines investigation, deeper understanding GIP. In this review, we provide detailed overview on multifaceted nature discuss implications signal modification various diseases. Following its classification hormone, emerged pleiotropic hormone with variety metabolic effects outside endocrine pancreas. The numerous render interesting candidate development pharmacotherapies obesity, diabetes, drug-induced nausea bone neurodegenerative disorders.

Language: Английский

Citations

3
The other side of the incretin story: GIPR signaling in energy homeostasis DOI
Susana Castelo Branco Ramos Nakandakari, Andin Fosam, Rachel J. Perry

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: 37(1), P. 1 - 3

Published: Jan. 1, 2025

Language: Английский

Citations

1
The Synergistic Impact of Glycolysis, Mitochondrial OxPhos, and PEP Cycling on ATP Production in Beta Cells DOI Open Access
Vladimir Grubelnik, Jan Zmazek, Marko Marhl

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1454 - 1454

Published: Feb. 10, 2025

Pancreatic beta cells regulate insulin secretion in response to glucose by generating ATP, which modulates ATP-sensitive potassium channels (KATP) channel activity and Ca2+ dynamics. We present a model of ATP production pancreatic cells, focusing on dynamics within the bulk cytosol, submembrane region, microdomains near KATP channels. is generated through glycolysis, mitochondrial oxidative phosphorylation (OxPhos), glycolytic pyruvate kinase-mediated phosphoenolpyruvate (PEP) production, supported PEP cycling between mitochondria cytosol. The examines relation oscillations, elucidating their interdependent Our findings demonstrate that both OxPhos PEP-mediated contribute substantially cellular levels. Specifically, glycolysis are crucial for initial (first-phase) increase subplasmalemmal effectively “filling up” pool cells. In second phase, coordinated pathways enables cost-effective fine-tuning levels, with localized effects microdomains. This addresses clarifies recent debate regarding mechanisms sufficient concentrations achieved close glucose-stimulated offering novel insights into regulation energy activity.

Language: Английский

Citations

0
FAcTs on fire: Exploring thermogenesis DOI

Amanda Rodríguez-Díaz,

Carlos Diéguez, Miguel López

et al.

Advances in genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Single-nucleus RNA sequencing reveals dynamic changes in the microenvironment of visceral adipose tissue and metabolic characteristics after cold exposure DOI Creative Commons

Ting Yi,

Shuai Wu,

Yang Yu-sha

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Introduction Visceral adipose tissue (VAT) plays a crucial role in regulating systemic metabolic balance. Excess accumulation of VAT is closely associated with various disorders, process that involves the coordinated actions multiple cell types within tissue. Cold exposure, as potential intervention, has been proposed to improve dysfunction. However, heterogeneity and its comprehensive characteristics under cold exposure remain unclear. Methods We collected epididymal white (eWAT) C57BL/6J mice after at three different time points for single-nucleus RNA sequencing (snRNA-seq) analysis. Results successfully identified ten major eWAT, enabling understanding dynamic changes eWAT microenvironment features during exposure. This study revealed 1 day reduced cellular activity intercellular communication including receptor-ligand-based metabolite-mediated interactions. 14 days acclimation, adipocytes was significantly enhanced, restored. Additionally, prolonged promoted formation distinct adipocyte subpopulation may be UCP1-independent thermogenesis. These new homeostatic state established by adapt environment. The also importance adipocytes, stem progenitor cells, myeloid endothelial cells adaptation. Discussion research provides valuable insights into heterogeneity, remodeling, reprogramming It highlights critical transcriptional dynamics perspectives on prevention treatment diseases.

Language: Английский

Citations

0
Browning of inguinal white adipose tissue by the novel lignan (−)-secoisolariciresinol 4-O-methyl ether attenuates diet-induced obesity through mitochondrial and Peroxisomal activation DOI
Wenjun Jiao, Woo Yong Park, Young‐Il Kim

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 119952 - 119952

Published: April 1, 2025

Language: Английский

Citations

0
Adipose Tissue as a Major Launch Spot for Circulating Extracellular Vesicle-Carried MicroRNAs Coordinating Tissue and Systemic Metabolism DOI Open Access

Paula Diez-Roda,

Esther Pérez‐Navarro, Rubén García-Martín

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13488 - 13488

Published: Dec. 17, 2024

Circulating microRNAs (miRNAs), especially transported by extracellular vesicles (EVs), have recently emerged as major new participants in interorgan communication, playing an important role the metabolic coordination of our tissues. Among these, adipose tissue displays extraordinary ability to secrete a vast list EV-carried miRNAs into circulation, representing hormone-like factors. Despite limitations current methodologies for unequivocal identification origin and destination vivo, recent investigations clearly support regulatory adipose-derived circulating shaping metabolism function other tissues including liver, muscle, endocrine pancreas, cardiovascular system, gastrointestinal tract, brain. Here, we review most findings regarding EVs (AdEVs) targeting organs implications this dialog physiology pathology. We also here potential future diagnostic therapeutic applications AdEV-carried miRNAs.

Language: Английский

Citations

0