Nirmatrelvir/ritonavir treatment and risk for postacute sequelae of COVID-19 in older Singaporeans

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: 31(1), P. 93 - 100

Published: Aug. 28, 2024

Language: Английский

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Risk of Post-Acute Sequelae of COVID-19 and Oral Antivirals in Adults Aged Over 60 years: A Nationwide Retrospective Cohort Study

International Journal of Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 107850 - 107850

Published: Feb. 1, 2025

To investigate the association between oral antiviral administration and post-acute sequelae of COVID-19 (PASC) risk in Korea. This retrospective cohort study used data from Korea Disease Control Prevention Agency Health Insurance Review Assessment Service. We analyzed patients aged > 60 years January to December 2022. The primary outcome was occurrence 27 PASCs within 30-120 days after diagnosis. hazard ratio calculated using Cox proportional hazards model. Nirmatrelvir/ritonavir significantly reduced cardiovascular diseases, including heart failure cardiomyopathies (aHR, 0.86), cardiac dysrhythmias 0.83), ischemic stroke 0.88). Moreover, it also lowered hospitalization due respiratory diseases chronic obstructive pulmonary disease 0.92) decreased renal disorders dialysis needs 0.57) acute 0.85). Molnupiravir 0.84) other cerebrovascular 0.84). Respiratory conditions by approximately 13-14% 0.87 0.86, respectively). molnupiravir ambulatory were associated with PASC risk; thus, antivirals may mitigate indirect SARS-CoV-2 infection effects.

Language: Английский

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Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(4), P. e252959 - e252959

Published: April 2, 2025

This cohort study estimates the risk of new-onset type 2 diabetes after Delta or Omicron variant SARS-CoV-2 infection among vaccinated adults in Singapore.

Language: Английский

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Post-COVID-19 Multimorbidity Incidence by Prior Vaccination Status In People with One Pre-Existing Condition: A Population-Based Cohort Study Of Over One Million Individuals

Published: Jan. 1, 2025

Language: Английский

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COVID-19 vaccination modified the effect of nirmatrelvir–ritonavir on post-acute mortality and rehospitalization: a retrospective cohort study

Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 13(1)

Published: Nov. 4, 2024

While previous research examined coronavirus disease 2019 (COVID-19) antiviral-vaccine interactions through exploratory subgroup analysis, none specifically designed for examining this interaction or its impact on post-acute outcomes. This study the between nirmatrelvir–ritonavir and complete COVID-19 vaccination reducing risk of outcomes among patients. We followed patients hospitalized 11 March 2022 10 October 2023, until 31 2023 in Hong Kong. Exposure groups were based usage status (fully not fully vaccinated). Post-acute death all-cause rehospitalization Propensity score weighting was applied to balance covariates exposure groups, including age, sex, Charlson Comorbidity Index, concomitant treatments. Multiplicative additive assessed. A total 50,438 included arranged into four groups. Significant observed (relative excess risk, 0.10; 95% CI, 0.02–0.19; p-value, 0.018; attributable proportion, 0.07; 0.01–0.12; 0.017; synergy index, 1.26; 1.02–1.55; 0.032). The mortality marginally significant. In effect is more pronounced older adults, female, CoronaVac recipients. conclusion, our demonstrated an outcomes, suggesting greater long-term benefits antiviral vaccinated individuals compared

Language: Английский

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Risk of death and cardiovascular events following COVID-19 vaccination or positive SARS-CoV-2 test amongst adult Singaporeans during omicron transmission

Vaccine, Journal Year: 2024, Volume and Issue: 42(26), P. 126356 - 126356

Published: Sept. 18, 2024

Language: Английский

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A bidirectional Mendelian randomization analysis between COVID-19 and cardiac arrest

International Journal of Environmental Health Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: June 12, 2024

Epidemiological studies link COVID-19 to increased cardiac arrest (CA) risk, but causality remains unclear due potential confounding factors in observational . We conducted a Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data, employing COVID-19-associated single nucleotide polymorphisms (SNPs) with significance values smaller than 5 × 10⁻⁸. calculated inverse-variance weighted (IVW) MR estimates and performed sensitivity analyses methods robust horizontal pleiotropy. Additionally, reverse was CA-associated SNPs 1 10⁻⁵. Results indicated that infected (OR = 1.12, 95% CI 0.47-2.67,

Language: Английский

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COVID-19 vaccination prevents venous thrombosis in patients with SARS-CoV-2 infection and thereafter

Blood Coagulation & Fibrinolysis, Journal Year: 2024, Volume and Issue: 35(5), P. 225 - 226

Published: July 1, 2024

aSection of Clinical Biochemistry, University Verona, Italy bDepartment Haematology, Institute Pathology and Medical Research (ICPMR), Sydney Centres for Thrombosis Haemostasis, NSW Health Pathology, Westmead Hospital, cFaculty Science Health, Charles Sturt University, Wagga dSchool Sciences, Faculty Medicine Sydney, Westmead, New South Wales, Australia Correspondence to Prof. Giuseppe Lippi, Section Hospital Piazzale L.A. Scuro, 10, 37134 Italy. Tel: +39 045 8122970; fax: 8124308; e-mail: [email protected] Received 5 April, 2024 Accepted 12 May,

Language: Английский

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