Journal of Neuroscience Methods, Journal Year: 2023, Volume and Issue: 394, P. 109884 - 109884
Published: May 17, 2023
Language: Английский
Journal of Neuroscience Methods, Journal Year: 2023, Volume and Issue: 394, P. 109884 - 109884
Published: May 17, 2023
Language: Английский
Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(2), P. 025012 - 025012
Published: Jan. 15, 2024
Objective. Delineating Parkinson's disease (PD) into distinct subtypes is a major challenge. Most studies use clinical symptoms to label PD while our work uses an imaging-based data-mining approach subtype PD. Our study comprises two objectives - firstly, subtyping patients based on grey matter information from structural magnetic resonance imaging scans of human brains; secondly, comparative brain connectivity analysis derived the former step.Approach. Source-based-morphometry decomposition was performed 131 and 78 healthy controls PPMI dataset, derive at components (regions) with significance in high effect size. The loading coefficients significant were thresholded for arriving subtypes. Further, regional maps subtype-specific subjects separately parcellated employed construction association matrices using Pearson correlation. These binarized sparsity threshold leveraged network metrics.Main results. Two (namely A B) detected employing loadings satisfying selection criteria, third (AB) detected, common these components. Subtype highly weighted inferior, middle superior frontal gyri B temporal gyri. Network metrics analyses through permutation test revealed inter-subtype differences (p < 0.05) clustering coefficient, local efficiency, participation coefficient betweenness centrality. Moreover, hubs obtained centrality mean degree.Significance. MRI-based data-driven show lobes playing key role Graph theory-driven could untangle connections showing differential architecture. Replication initial results other datasets may be explored future. Clinical Relevance- Investigating provide treatment.
Language: Английский
Citations
4Parkinsonism & Related Disorders, Journal Year: 2021, Volume and Issue: 85, P. 84 - 90
Published: March 18, 2021
Language: Английский
Citations
242022 IEEE 3rd Global Conference for Advancement in Technology (GCAT), Journal Year: 2022, Volume and Issue: unknown, P. 1 - 5
Published: Oct. 7, 2022
The non-curable neurological disorder that affects the motor system is known as Parkinson disease. When disease detected earlier, then it can diagnose, and we get a quick relief but not permanent. neurons segregate chemical called dopamine. That helps for transmitting signs to other in brain. dopamine flow starts fall, PD occurs. This makes patients to, resting tremors, bradykinesia rigidity problems. Here machine-learning dramatizations position patterns tag biomedical sciences. mainly attack so be analysed by Magnetic Resonance Imaging (MRI) scan, one detect predict In this paper, with MRI scan Parkinson's using CNN, VGG-16 model ResNET-50. ResNet-50 are compared find best based on accuracy.
Language: Английский
Citations
18Current Psychology, Journal Year: 2022, Volume and Issue: 42(20), P. 16637 - 16660
Published: Feb. 27, 2022
Language: Английский
Citations
17Journal of Neuroscience Methods, Journal Year: 2023, Volume and Issue: 394, P. 109884 - 109884
Published: May 17, 2023
Language: Английский
Citations
10