Homocysteine Mediates Cognitive Inflexibility Induced by Stress via Targeting PIN1

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 416 - 416

Published: April 19, 2025

Increasing evidence shows that HCY plays an important role in stress-induced cognitive dysfunction, and significantly promotes the decline of function. Stress has been reported to cause elevated hippocampus mice. Cognitive flexibility refers ability individuals quickly adjust their neurobehavioral strategies different situations or solve tasks. This study aims explore impairment induced by stress its possible regulatory mechanism. First, we examined changes protein mRNA levels effector molecule, PIN1, during The results show can a mice lead increase PIN1. Moreover, through use vitro experiments, found could induce PIN1 expression neurons. Further vivo experiments were used investigate effect VitB on evaluated therapeutic flexibility. decreased plasma hippocampus, alleviated flexibility, reduced These suggest be inhibited regulating content HCY. Collectively, our findings highlight aimed at improving treatment for impairments

Language: Английский

Editorial overview: Cognitive flexibility

Current Opinion in Behavioral Sciences, Journal Year: 2025, Volume and Issue: 64, P. 101534 - 101534

Published: May 12, 2025

Language: Английский