Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3131 - 3131

Published: March 28, 2025

Hydrogen sulfide (H2S) has emerged as a pivotal gaseous transmitter in the central nervous system, influencing synaptic plasticity, learning, and memory by modulating various molecular pathways. This review examines recent evidence regarding how H2S regulates NMDA receptor function neurotransmitter release neuronal circuits. By synthesizing findings from animal cellular models, we investigate impacts of enzymatic production exogenous on excitatory currents, long-term potentiation, intracellular calcium signaling. Data suggest that interacts directly with subunits, altering excitability. Simultaneously, promotes neurotransmitters such glutamate GABA, shaping dynamics plasticity. Furthermore, reports indicate disruptions metabolism contribute to cognitive impairments neurodegenerative disorders, underscoring potential therapeutic value targeting H2S-mediated Although precise mechanisms H2S-induced changes strength remain elusive, growing body positions significant regulator formation processes. calls for more rigorous exploration into underpinnings paving way novel pharmacological interventions dysfunction.

Language: Английский

Efficacy of Radio Electric Asymmetric Conveyer Neuro Psycho Physical Optimization - Brain Wave Optimization-Gamma (REAC NPPO BWO-G) Treatment in Neurovegetative Dysfunction: A Case Report of Enhanced Cognitive Processing and Stress Resilience

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Neurovegetative dysfunction from chronic stress impairs cognition, emotional regulation, and quality of life, with limited relief conventional therapies. The Radio Electric Asymmetric Conveyer (REAC) Neuro Psycho Physical Optimization - Brain Wave Optimization-Gamma (NPPO BWO-G) offers a novel non-invasive approach to restore autonomic balance through brain modulation. This case involves 63-year-old businessman atrial fibrillation, fatigue, cognitive decline, sleep issues. Pre-treatment quantitative electroencephalogram (qEEG) showed low activity excess delta rhythms. After REAC NPPO BWO-G sessions, the patient experienced improved brainwave patterns, clarity, management, reduced fatigue. These results highlight its potential as promising treatment for stress-related neurovegetative dysfunction, warranting further study.

Language: Английский