Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(66)
Published: Oct. 16, 2024
Abstract
Carboxylic
acids
are
attractive
synthetic
feedstocks
with
stable,
non‐toxic,
and
inexpensive
properties
that
can
be
easily
obtained
from
natural
sources
or
through
synthesis.
have
long
been
considered
environmentally
friendly
coupling
agents
in
various
organic
transformations.
In
recent
years,
electrochemically
mediated
decarboxylation
reactions
of
decarboxylic
their
derivatives
(NHPI)
emerged
as
effective
new
methods
for
constructing
carbon‐carbon
carbon‐heterocarbon
chemical
bonds.
Compared
transition
metal
photochemistry‐mediated
catalytic
reactions,
which
do
not
require
the
addition
oxidants
strong
bases,
electrochemically‐mediated
decarboxylative
transformations
a
sustainable
strategy.
addition,
functional
groups
tolerate
electrochemical
conversion
strategy
well.
Here,
we
summarize
to
better
elucidate
advantages
reactions.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(42), P. 5502 - 5505
Published: Jan. 1, 2024
An
organophotoelectrocatalytic
method
for
the
C(sp
2
)–H
alkylation
of
heteroarenes
with
unactivated
3
compounds
via
dehydrogenation
cross-coupling
was
developed.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(16), P. 1913 - 1928
Published: April 24, 2024
Comprehensive
Summary
Organic
fluorine
compounds
are
ubiquitous
and
pivotally
important
organic
molecules,
yet
their
activation
transformation
have
long
been
a
formidable
challenge
due
to
the
high
energy
low
reactivity
of
C—F
bonds.
electrosynthesis,
an
environmentally
benign
synthetic
method
in
chemistry,
enables
myriad
chemical
transformations
without
need
for
external
redox
reagents.
In
recent
years,
electrochemistry
has
emerged
as
powerful
tool
achieving
bonds
fluorine‐containing
compounds.
This
review
aims
succinctly
recapitulate
latest
advancements
electrochemical
defluorinative
delve
into
reaction
design,
mechanistic
insights,
developmental
prospects
these
methods.
Key
Scientists
1959,
Lund
was
first
pioneer
electroreduction
CF
3
CH
group.
Electrochemistry
lately
provided
new
opportunities
efficient
conversion
fluorides.
2020,
Zhou
coworkers
discovered
carboxylation
α‐CF
alkenes.
Lambert
colleagues
reported
electrophotocatalytic
amination
aryl
Electrochemical
hydrodefluorination
trifluoromethylketones
developed
by
Lennox
2021.
same
year,
Wang
Guo
disclosed
radical
alkylation
alkenes
with
Katritzky
salts
alkyl
precursors.
Subsequently,
Wu
Liao
described
transition‐metal‐free,
site‐selective
arylation
polyfluoroarenes
(het)arenes
using
paired
electrophotocatalysis.
2023,
numerous
efforts
were
made
achieve
bond
activation.
Xia
organoboron‐controlled
chemoselective
sequential
(deutero)hydrodefluorination
trifluoroacetamides.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
highlights
organo-mediators
that
enable
electrochemical
reactions
via
outer-sphere
electron
transfer
(ET),
offering
advantages
such
as
availability,
tunability,
and
simplified
post-processing
compared
to
direct
electrolysis.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(19), P. 2346 - 2350
Published: May 27, 2024
Comprehensive
Summary
Catalytic
and
green
strategies
for
the
synthesis
of
privileged
scaffolds
are
synthetically
appealing.
We
now
report
a
radical‐polar
crossover
(RPC)‐enabled
three‐component
cyclization
bromodifluoroalkyls
with
enaminones
6‐aminouraciles
via
visible‐light‐induced
domino
cyclization.
The
reaction
exhibited
broad
substrate
scope
(>
40
examples)
including
complex
molecules,
which
highlighted
utility
this
strategy
construction
library
bioactive
analogs.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(11), P. 7531 - 7540
Published: May 18, 2024
An
organocatalyzed
photoelectrochemical
method
for
the
generation
of
acyl
and
phosphoryl
radicals
from
formamides,
aldehydes,
phosphine
oxides
has
been
developed.
This
protocol
utilizes
9,10-phenanthrenequinone
(PQ)
as
both
a
molecular
catalyst
hydrogen
atom-transfer
(HAT)
reagent,
eliminating
requirement
external
metal-based
reagents,
HAT
oxidants.
The
generated
can
be
applied
to
range
radical-mediated
transformation
reactions,
including
C–H
carbamoylation
heteroarenes,
intermolecular
tandem
radical
cyclization
CF3-substituted
N-arylacrylamides,
well
intramolecular
reactions.
use
in
these
transformations
offers
an
efficient
sustainable
approach
accessing
structurally
diverse
carbonyl
compounds.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(20), P. 4067 - 4071
Published: Jan. 1, 2024
Rapid
assembly
of
quinoxalines
in
a
single
step
from
readily
available
precursors
has
been
recognized
as
an
ideal
platform
terms
efficiency
and
operation.
Herein,
we
report
BPO-promoted
metal-free
approach
to
2-acyl
enaminones
