Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(66)
Published: Oct. 16, 2024
Abstract
Carboxylic
acids
are
attractive
synthetic
feedstocks
with
stable,
non‐toxic,
and
inexpensive
properties
that
can
be
easily
obtained
from
natural
sources
or
through
synthesis.
have
long
been
considered
environmentally
friendly
coupling
agents
in
various
organic
transformations.
In
recent
years,
electrochemically
mediated
decarboxylation
reactions
of
decarboxylic
their
derivatives
(NHPI)
emerged
as
effective
new
methods
for
constructing
carbon‐carbon
carbon‐heterocarbon
chemical
bonds.
Compared
transition
metal
photochemistry‐mediated
catalytic
reactions,
which
do
not
require
the
addition
oxidants
strong
bases,
electrochemically‐mediated
decarboxylative
transformations
a
sustainable
strategy.
addition,
functional
groups
tolerate
electrochemical
conversion
strategy
well.
Here,
we
summarize
to
better
elucidate
advantages
reactions.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(17), P. 11950 - 11958
Published: Aug. 19, 2024
An
environmentally
friendly
electrochemical
strategy
for
the
synthesis
of
SCF3-containing
oxindoles
was
developed.
This
transformation
accomplished
through
a
cascade
trifluoromethylthiolation/cyclization
N-acrylamides
with
AgSCF3,
obviating
requirement
external
oxidants.
A
variety
functional
groups
were
well
tolerated
in
this
transformation.
Authorea (Authorea),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 27, 2024
Catalytic
and
green
strategies
for
the
synthesis
of
privileged
scaffolds
are
synthetically
appealing.
We
now
reported
a
radical-polar
crossover
(RPC)-enabled
three-component
cyclization
bromodifluoroalkyls
with
enaminones
6-aminouraciles
via
visible-light-induced
dom-ino
cyclization.
The
reaction
exhibited
broad
substrate
scope
(>
40
examples)
including
complex
molecules,
which
highlighted
utility
this
strategy
construction
library
bioactive
analogs.
Abstract
Synthetic
electrochemistry
may
establish
direct
routes
to
a
preparation
of
plethora
organic
substances,
which
are
hardly
accessible
by
conventional
experimental
techniques.
Herein,
we
present
an
electrochemically‐driven
method
for
assembly
broad
range
rare
heterocyclic
mesoionic
entities
–1,2,3‐triazole
1‐imines.
These
nitrogen
heterocycles
were
prepared
through
transition‐metal‐
and
exogenous
oxidant‐free
strategy
using
C/Ni
electrode
pair.
Over
30
examples
thus
synthesized
1,2,3‐triazole
1‐imines
illustrate
selectivity
practical
utility
this
approach.
Key
solvent‐controlled
reactivity
patterns
the
formation
triazole
imine
scaffold
revealed
indicating
modulation
ability
developed
findings
additionally
justified
based
on
cyclic
voltammetry
(CV)
data
density
functional
theory
(DFT)
calculations.
Moreover,
according
differential
scanning
calorimetry
(DSC)
data,
some
correspond
thermally
stable
species
with
onset
decomposition
temperature
up
190
°C.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(66)
Published: Oct. 16, 2024
Abstract
Carboxylic
acids
are
attractive
synthetic
feedstocks
with
stable,
non‐toxic,
and
inexpensive
properties
that
can
be
easily
obtained
from
natural
sources
or
through
synthesis.
have
long
been
considered
environmentally
friendly
coupling
agents
in
various
organic
transformations.
In
recent
years,
electrochemically
mediated
decarboxylation
reactions
of
decarboxylic
their
derivatives
(NHPI)
emerged
as
effective
new
methods
for
constructing
carbon‐carbon
carbon‐heterocarbon
chemical
bonds.
Compared
transition
metal
photochemistry‐mediated
catalytic
reactions,
which
do
not
require
the
addition
oxidants
strong
bases,
electrochemically‐mediated
decarboxylative
transformations
a
sustainable
strategy.
addition,
functional
groups
tolerate
electrochemical
conversion
strategy
well.
Here,
we
summarize
to
better
elucidate
advantages
reactions.
