Emerging contaminants: A One Health perspective

The Innovation, Journal Year: 2024, Volume and Issue: 5(4), P. 100612 - 100612

Published: March 13, 2024

Language: Английский

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A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS)

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178240 - 178240

Published: Jan. 1, 2025

This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information

Language: Английский

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Structural Characterization of Dimeric Perfluoroalkyl Carboxylic Acid Using Experimental and Theoretical Ion Mobility Spectrometry Analyses

Journal of the American Society for Mass Spectrometry, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Per- and polyfluoroalkyl substances (PFAS) are contaminants of increasing concern, with over seven million compounds currently inventoried in the PubChem PFAS Tree. Recently, ion mobility spectrometry has been combined liquid chromatography high-resolution mass (LC-IMS-HRMS) to assess PFAS. Interestingly, using negative electrospray ionization, perfluoroalkyl carboxylic acids (PFCAs) form homodimers ([2M-H]-), a phenomenon observed trapped, traveling wave, drift-tube IMS. In addition limited research on their effect analytical performance, there is little information conformations these dimers can adopt. This study aimed propose most probable for PFCA dimers. Based qualitative analysis how collision cross section (CCS) values change mass-to-charge ratio (m/z) ions, were hypothesized likely adopt V-shaped structure. To support this assumption, silico geometry optimizations performed generate set conformers each possible dimer. A CCS value was then calculated conformer trajectory method Lennard-Jones ion-quadrupole potentials. Among conformers, at least one ten lowest-energy identified dimer exhibited theoretical within ±2% error margin compared experimental data, qualifying them as plausible structures Our findings revealed that fluorinated alkyl chains close other due combination C-F···O=C C-F···F-C stabilizing interactions. These findings, together supplementary investigations involving environmentally relevant cations, may offer valuable insights into interactions environmental behavior

Language: Английский

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Differential impact of perfluorooctanoic acid and fluorotelomer ethoxylates on placental metabolism in mice

Chemosphere, Journal Year: 2024, Volume and Issue: 356, P. 141923 - 141923

Published: April 8, 2024

Language: Английский

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Serum per- and polyfluoroalkyl substance (PFAS) levels and health-related biomarkers in a pilot study of skiers in New England

Environmental Research, Journal Year: 2024, Volume and Issue: 263, P. 120122 - 120122

Published: Oct. 9, 2024

Language: Английский

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