Decoding the Function of FGFBP1 in Sheep Adipocyte Proliferation and Differentiation DOI Creative Commons

Liming Tian,

Zhaohua He, Guan Wang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(10), P. 1456 - 1456

Published: May 18, 2025

Tail adipose deposition in sheep is an economically significant trait that has impact on meat quality and reproductive performance. This study elucidates the regulatory mechanism of FGFBP1 proliferation differentiation ovine tail-derived preadipocytes. Overexpression knockdown methods were used to establish gain- loss-of-function models, biological effects adipocyte dynamics systematically assessed. overexpression significantly inhibited cellular by cell cycle arrest G2/M phase, and, at same time, promoted upregulating key adipogenic markers (PPARγ, Adiponectin, C/EBPα, FABP4). In contrast, gene silencing enhanced proliferative capacity decreased lipid droplet accumulation, confirming its inhibitory role adipogenesis. Our findings indicate a regulator tail discovery enhances our understanding mechanisms provides theoretical bases potential therapeutic targets for optimizing traits livestock production.

Language: Английский

Decoding ex vivo tissue-like growth of fish vs mammalian cells as scalable cell-based food DOI

Jing Yu,

Qian Lu,

Rongli Niu

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105019 - 105019

Published: April 1, 2025

Language: Английский

Citations

0
Genome-scale metabolic models in cultivated meat: advances, challenges, and future directions DOI Creative Commons
Sandra Gomez Romero,

Isabella Spielmann,

Nanette R. Boyle

et al.

Current Opinion in Biotechnology, Journal Year: 2025, Volume and Issue: 94, P. 103313 - 103313

Published: May 15, 2025

Cultivated meat is an emerging field that integrates stem cell biology, tissue engineering, and bioprocessing to create a sustainable alternative conventional meat. However, its widespread adoption faces key metabolic challenges, including the need for serum-free media, optimization of line-specific growth conditions, enhanced cellular engineering strategies. GEnome-scale Metabolic models (GEMs) have been instrumental in optimizing conditions Chinese hamster ovaries, powerhouse species biomanufacturing, they can be adapted used cultivated same way. These facilitate transition cost-effective, media improve biomass production through flux analysis. Future advancements will require expanding publicly available data sets, refining models, integrating transcriptomic proteomic enhance predictive accuracy. By leveraging GEMs, overcome current limitations, paving way scalable, sustainable, economically viable traditional

Language: Английский

Citations

0
Decoding the Function of FGFBP1 in Sheep Adipocyte Proliferation and Differentiation DOI Creative Commons

Liming Tian,

Zhaohua He, Guan Wang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(10), P. 1456 - 1456

Published: May 18, 2025

Tail adipose deposition in sheep is an economically significant trait that has impact on meat quality and reproductive performance. This study elucidates the regulatory mechanism of FGFBP1 proliferation differentiation ovine tail-derived preadipocytes. Overexpression knockdown methods were used to establish gain- loss-of-function models, biological effects adipocyte dynamics systematically assessed. overexpression significantly inhibited cellular by cell cycle arrest G2/M phase, and, at same time, promoted upregulating key adipogenic markers (PPARγ, Adiponectin, C/EBPα, FABP4). In contrast, gene silencing enhanced proliferative capacity decreased lipid droplet accumulation, confirming its inhibitory role adipogenesis. Our findings indicate a regulator tail discovery enhances our understanding mechanisms provides theoretical bases potential therapeutic targets for optimizing traits livestock production.

Language: Английский

Citations

0