Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 978 - 1002
Published: March 15, 2024
Despite
the
reported
successes
and
advantages
involving
use
of
amphiphilic
surfactants,
most
notably
TPGS-750-M,
to
enable
a
multitude
synthetic
transformations
be
conducted
in
water,
implementation
this
methodology
within
pharmaceutical
industry
has
been
relatively
limited.
In
paper,
we
will
disclose
key
results
learnings
from
multicompany
collaboration
focused
on
reproducibility
study
some
commonly
used
reaction
types
industry,
specifically
amidation,
SNAr,
nitro
reduction,
reductive
amination,
multiple
Pd-catalyzed
water.
The
presentation
not
just
originally
TPGS-750-M
conditions
but
also
under
water-only
control
with
three
different
as
well
both
small
(i.e.,
≤500
mg)
mid
(∼10
g)
scales.
Organometallics,
Journal Year:
2022,
Volume and Issue:
41(22), P. 3084 - 3098
Published: Aug. 15, 2022
Micelles
generated
upon
dissolving
surfactants
in
water
can
be
employed
as
nanovessels
for
catalytic
transformations,
the
so-called
micellar
catalysis
methodology.
This
review
is
focused
on
use
of
context
functionalization
carbon–hydrogen
bonds.
The
micelles
accumulate
catalyst
and
reactants
their
inner
volume
such
a
high
local
concentration
that
kinetics
are
favored.
consequence
that,
most
cases,
processes
conventional
organic
solvents
require
temperatures
long
reaction
times
achieved
milder
conditions
when
employed.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(7), P. 2782 - 2789
Published: Jan. 1, 2023
Herein,
we
report
a
green
and
sustainable
Cu-catalysed
Chan–Lam
oxidative
protocol
for
the
synthesis
of
(hetero)aryl
selenides/sulfides
from
diorganyl
dichalcogenides
boronic
acids
in
an
aqueous
micellar
medium.
Industrial & Engineering Chemistry Research,
Journal Year:
2024,
Volume and Issue:
63(3), P. 1334 - 1348
Published: Jan. 8, 2024
Catalytic
oxidation
of
benzyl
alcohol
(BA),
p-chlorobenzyl
(p-ClBA)
and
p-anisyl
(p-OMeBA)
in
aqueous
media
has
been
investigated
the
presence
two
cationic
surfactants,
viz.
cetylpyridinium
chloride
(CPCl)
dodecylpyridinium
(DPCl).
The
chromium(VI)-governed
oxidations
such
aromatic
compounds
exhibit
an
unusual
kinetics
depending
upon
concentration
CPCl
DPCl.
Both
surfactants
catalyzed
at
lower
concentrations
while
retardation
was
noticed
higher
concentrations.
catalytic
inhibitory
functions
both
sub-
postmicellar
levels
have
enlightened
based
on
kinetic
CMC
(critical
micellization
concentration).
chain
length
influences
profiles
processes.
Herein,
π–π
interaction
cation−π
play
important
roles
solubilization
process
therefore
encourage
reaction
rate.
These
strong
interactions
result
a
maximum
12-fold
enhancement
for
micellar
environment,
effect
DPCl
analyzed
dilution
effect.
morphological
alteration
aggregates
during
aids
interpretation
activity
micelles
produced
by
and/or
Berezin's
model
employed
to
reveal
inhibition
caused
micelles.
Morphological
from
spherical-to-cylindrical
shape
variable
absence
substrate
supported
SAXS
(small-angle
X-ray
scattering),
TEM
(transmission
electron
microscopy),
FE-SEM
(field
emission
scanning
microscopy)
analysis.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 978 - 1002
Published: March 15, 2024
Despite
the
reported
successes
and
advantages
involving
use
of
amphiphilic
surfactants,
most
notably
TPGS-750-M,
to
enable
a
multitude
synthetic
transformations
be
conducted
in
water,
implementation
this
methodology
within
pharmaceutical
industry
has
been
relatively
limited.
In
paper,
we
will
disclose
key
results
learnings
from
multicompany
collaboration
focused
on
reproducibility
study
some
commonly
used
reaction
types
industry,
specifically
amidation,
SNAr,
nitro
reduction,
reductive
amination,
multiple
Pd-catalyzed
water.
The
presentation
not
just
originally
TPGS-750-M
conditions
but
also
under
water-only
control
with
three
different
as
well
both
small
(i.e.,
≤500
mg)
mid
(∼10
g)
scales.
