Published: Jan. 1, 2024
Language: Английский
Nature Immunology, Journal Year: 2023, Volume and Issue: 24(6), P. 903 - 914
Published: May 8, 2023
Language: Английский
Citations
155
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 7, 2025
Abstract The mucosal immune system, as the most extensive peripheral network, serves frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion establishing tolerance. A comprehensive understanding immunity essential for developing treatments that can effectively target diseases at their entry points, thereby minimizing overall impact on body. Despite its importance, our knowledge remains incomplete, necessitating further research. outbreak severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has underscored critical role disease prevention treatment. This systematic review focuses dynamic interactions between mucosa-associated lymphoid structures related diseases. We delve into basic functions these tissues during processes explore intricate regulatory networks mechanisms involved. Additionally, we summarize novel therapies clinical research advances immunity-related also addresses challenges vaccines, which aim to induce specific responses while maintaining tolerance non-pathogenic microbes. Innovative therapies, such nanoparticle vaccines inhalable antibodies, show promise enhancing offer potential improved
Language: Английский
Citations
6
Clinical & Translational Immunology, Journal Year: 2023, Volume and Issue: 12(5)
Published: Jan. 1, 2023
Abstract The link between Epstein–Barr virus (EBV) and multiple sclerosis (MS) has puzzled researchers since it was first discovered over 40 years ago. Until that point, EBV primarily viewed as a cancer‐causing agent, but the culmination of evidence now shows pivotal role in development MS. Early MS disease is characterised by episodic neuroinflammation focal lesions central nervous system (CNS) time develop into progressive neurodegeneration disability. Risk vanishingly low seronegative individuals, history infectious mononucleosis (acute symptomatic primary infection with EBV) significantly increases risk elevated antibody titres directed against antigens are well‐characterised patients. However, underlying mechanism – or mechanisms responsible for this interplay remains to be fully elucidated; how does EBV‐induced immune dysregulation either trigger drive susceptible individuals? Furthermore, deep understanding virological immunological events during long‐term persistence B cells will help answer many questions remain regarding pathogenesis. This review discusses current surrounding MS, which have important implications future therapies prevention.
Language: Английский
Citations
19
PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(9), P. e1011639 - e1011639
Published: Sept. 16, 2024
Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal viruses, in generating efficacious long-term humoral immunity. Due the necessity germinal center formation long-lived high affinity antibodies, has increasingly become a target for development novel or improvement less-efficacious vaccines. However, there remains major gap current research effectively T follicular helper cells during vaccination alter reaction. In this study, we used heterologous infection immunization priming strategy seed an antigen-specific memory CD4+ cell pool prior mice evaluate effect recalled increased help influenza-specific primary B and enhanced generation neutralizing antibodies. We found that with intranasal acute lymphocytic choriomeningitis virus (LCMV) intramuscular adjuvanted recombinant LCMV glycoprotein induced effector cellular responses following strain expresses glycoprotein. Heterologously primed had expansion secondary Th1 Tfh subsets, RM lung. early enhancement response did not impact antibody repertoires compared infection. Overall, our study suggests while is able enhance reaction, further studies understand how specifically increase antiviral immunity are needed.
Language: Английский
Citations
6
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 8, 2024
Radiation-induced lung injury is a common complication associated with radiotherapy. It characterized by early-stage radiation pneumonia and subsequent pulmonary fibrosis. However, there currently lack of effective therapeutic strategies for radiation-induced injury. Recent studies have shown that tolerogenic dendritic cells interact regulatory T and/or B to stimulate the production immunosuppressive molecules, control inflammation, prevent overimmunity. This highlights potential new activity in managing In this review, we aim provide comprehensive overview context injury, which will be valuable researchers field.
Language: Английский
Citations
4
The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(7)
Published: April 25, 2024
During secondary infection with influenza virus, plasma cells (PCs) develop within the lung, providing a local source of antibodies. However, site and mechanisms that regulate this process are poorly defined. Here, we show while circulating memory B entered lung during rechallenge were activated inducible bronchus-associated lymphoid tissues (iBALTs), resident (BRM) responded earlier, their activation occurred in different niche: directly near infected alveoli. This required NK but was largely independent CD4 CD8 T cells. Innate stimuli induced by virus-like particles containing ssRNA triggered BRM cell differentiation absence cognate antigen, suggesting low threshold activation. In contrast, expansion PCs iBALTs took longer to critically dependent on Our work demonstrates spatially distinct evolved support pulmonary PC responses, it reveals specialized function for as guardians
Language: Английский
Citations
4
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 29, 2025
The mucosal system serves as the primary barrier against respiratory diseases and plays a crucial role in combating viral infections through immunity. resident microbial community constitutes main component of exerts significant inhibitory impact on invasion exogenous agents. However, precise relationship between microbiota, immunity, remains incomplete. This review aims to summarize regulatory interactions microbiota innate immune components such immunity trained By clarifying these complex relationships, this seeks identify potential targets for augmenting disease prevention strategies developing novel vaccine formulations. Furthermore, we propose possibility integrating fields microbiome-based therapeutics development create multifunctional formulations capable targeting induction. Such an approach holds great offering pathways treatment diseases.
Language: Английский
Citations
0
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 26, 2025
Diabetic panvascular disease (DPD) is the leading clinical complication of diabetes mellitus (DM), characterized by atherosclerosis across multiple organ vessels. It a major cause high disability and mortality rates in DM. However, pathological mechanisms key mediators DPD remain unclear. This study constructed single-cell organotypic atlas vasculature containing 321,358 cells integrating 14 datasets from 8 mouse organs tissues. A total 63 cell types were identified, including 9 vascular subtypes, whereas cell-to-cell interaction (CCI) patterns systematically analyzed. Endothelial (ECs) identified as type involved CCI within vasculature, with their ligands interacting receptors various types, which contribute to biological processes such stem differentiation immune regulation. Notably, examined cellular communication characteristics different EC subtypes. Additionally, inter-organ between heart kidney—key tissues DPD—was The BMP signaling pathway emerged critical cardiorenal complications DM, SGLT2i having regulatory role BMP6 modulation. provides, for first time, analysis highlights central ECs. Moreover, diabetic elucidated. These findings offer new insights into underlying co-morbidities provide novel scientific basis prevention, treatment strategies DPD, understanding action mechanism SGLT2i.
Language: Английский
Citations
0
Genes and Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: May 13, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 31, 2023
Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal viruses, in generating efficacious long-term humoral immunity. Due the necessity germinal center formation long-lived high affinity antibodies, has increasingly become a target for development novel or improvement less-efficacious vaccines. However, there remains major gap current research effectively T follicular helper cells during vaccination alter reaction. In this study, we used heterologous infection immunization priming strategy seed an antigen-specific memory CD4+ cell pool prior mice evaluate effect recalled increased help influenza-specific primary B and enhanced generation neutralizing antibodies. We found that with intranasal acute lymphocytic choriomeningitis virus (LCMV) intramuscular adjuvanted recombinant LCMV glycoprotein induced effector cellular responses following strain expresses glycoprotein. Heterologously primed had expansion secondary Th1 Tfh subsets,
Language: Английский
Citations
1