PANoptosis in Bacterial Infections: A Double-Edged Sword Balancing Host Immunity and Pathogenesis

Pathogens, Journal Year: 2025, Volume and Issue: 14(1), P. 43 - 43

Published: Jan. 8, 2025

PANoptosis is a newly identified programmed cell death pathway that integrates characteristics of apoptosis, pyroptosis, and necroptosis. It plays dual role in the host immune response to bacterial infections. On one hand, acts as protective mechanism by inducing infected cells eliminate pathogens releasing pro-inflammatory cytokines amplify response. other bacteria can exploit evade defenses. This nature underscores potential target for developing novel therapies against review summarizes molecular mechanisms PANoptosis, along with crosstalk integration different pathways various pathogens. We also discuss roles infectious diseases, including sepsis, pulmonary infections, intestinal Elucidating underlying how manipulate this offers critical insights into host-pathogen interactions. These provide foundation designing targeted antibacterial strategies, modulating inflammation, advancing precision medicine improve clinical outcomes.

Language: Английский

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Macrophage pyroptosis and its crucial role in ALI/ARDS

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Language: Английский

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Modeling Necroptotic and Pyroptotic Signaling in Saccharomyces cerevisiae

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 530 - 530

Published: April 4, 2025

The yeast Saccharomyces cerevisiae is the paradigm of a eukaryotic model organism. In virtue substantial degree functional conservation, it has been extensively exploited to understand multiple aspects genetic, molecular, and cellular biology human disease. Many cell signaling in cancer, aging, or metabolic diseases have tackled yeast. Here, we review strategies undertaken throughout years for development humanized models study regulated death (RCD) pathways general, specifically, those related innate immunity inflammation, with an emphasis on pyroptosis necroptosis. Such involve assembly distinct modular complexes such as inflammasome necrosome. Like other supramolecular organizing centers (SMOCs), intricate molecular arrangements trigger activity enzymes, like caspases protein kinases, culminating activation lytic pore-forming final effectors, respectively, Gasdermin D (GSDMD) MLKL Even though governing inflammation mammals are missing fungi, heterologous expression their components S. provides "cellular test tube" readily properties interactions, thus constituting valuable tool finding novel therapies.

Language: Английский

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Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives

Critical Care, Journal Year: 2025, Volume and Issue: 29(1)

Published: April 23, 2025

Language: Английский

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