Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses DOI Creative Commons

Mir J Howlader,

William G Ambler, Madhavi Latha Somaraju Chalasani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: June 16, 2022

Abstract Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated UVR-induced flares of disease, which involve increased autoantibodies further end organ injury. Mechanistic insight into the link between responses autoimmunity is limited. Signals from transmitted directly to immune system via lymphatic vessels, here we show evidence for potentiation flow dysfunction in SLE patients murine models. Improving by manual drainage (MLD) or a transgenic model vessels reduces both lymph node B T cell responses, long term MLD splenomegaly titers number autoantibodies. Mechanistically, improved restrains responsesS part stimulating fibroblastic reticular cell-monocyte axis. Our results point modulation stromal function as photosensitive therapeutic target lupus, provide mechanisms state regulates draining function, suggest possibility an accessible cost-effective adjunct add ongoing medical therapies related diseases.

Language: Английский

Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses DOI Creative Commons

Mir J Howlader,

William G Ambler, Madhavi Latha Somaraju Chalasani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: June 16, 2022

Abstract Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated UVR-induced flares of disease, which involve increased autoantibodies further end organ injury. Mechanistic insight into the link between responses autoimmunity is limited. Signals from transmitted directly to immune system via lymphatic vessels, here we show evidence for potentiation flow dysfunction in SLE patients murine models. Improving by manual drainage (MLD) or a transgenic model vessels reduces both lymph node B T cell responses, long term MLD splenomegaly titers number autoantibodies. Mechanistically, improved restrains responsesS part stimulating fibroblastic reticular cell-monocyte axis. Our results point modulation stromal function as photosensitive therapeutic target lupus, provide mechanisms state regulates draining function, suggest possibility an accessible cost-effective adjunct add ongoing medical therapies related diseases.

Language: Английский

Citations

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