Engineered hydrogel platform for diabetic wound healing
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 160379 - 160379
Published: Feb. 1, 2025
Language: Английский
A self-supplied hydrogen peroxide and nitric oxide-generating nanoplatform enhances the efficacy of chemodynamic therapy for biofilm eradication
Dongxu Jia,
No information about this author
Yi Zou,
No information about this author
Yuheng Zhang
No information about this author
et al.
Journal of Colloid and Interface Science,
Journal Year:
2024,
Volume and Issue:
678, P. 20 - 29
Published: Aug. 22, 2024
Language: Английский
Design and synthesis of novel substituted s‐triazines tethered benzenesulfonamides as potential antimicrobial candidates: Antibiofilm and bacterial protein permeability assessments
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(3)
Published: March 1, 2025
Abstract
New
s
‐triazine
hydrazone
hybrids
(
4a
–
4r
)
were
designed
and
synthesized
as
promising
microbial
DNA
gyrase
inhibitors.
This
was
done
by
taking
the
lead
inhibitor
(AstraZeneca
arylaminotriazine)
a
reference.
The
novel
samples
subsequently
tested
antimicrobial
agents
against
certain
pathogenic
bacteria
unicellular
fungi.
antibiofilm
potential
membrane
leakage
test
used
to
determine
mechanism
of
response.
minimum
inhibitory
concentration
(MIC)
values
4g
,
4i
between
62.5
250.0
µg/mL.
MIC
for
candidate
Staphylococcus
aureus,
Candida
albicans,
Enterobacter
agglomerans
Klebsiella
pneumonia
are
62.5,
125.0,
µg/mL,
respectively.
Conversely,
compound
µg/mL
C.
albicans
E.
125.0
S.
aureus
K.
.
Besides,
molecular
docking
study
performed
validate
both
binding
affinity
mode
newly
analogs
candidates
toward
bacterial
receptors.
nanocomposites
had
potentials,
which
encouraging
their
use
in
biomedical
applications.
Consequently,
afforded
compounds
can
be
employed
future
optimization.
Language: Английский
A Self‐Assembled Nanoreactor for Realizing Antibacterial Photodynamic/Gas Therapy and Promoting Wound Healing
Chenyang Jia,
No information about this author
Lingyi Li,
No information about this author
Qiu‐Yi Duan
No information about this author
et al.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 27, 2025
Abstract
Among
various
treatments
employed
to
solve
the
global
problem
of
bacterial
infection,
photodynamic
therapy
(PDT)
is
recognized
as
a
method
with
great
potential
inactivate
wide
range
bacteria
without
development
drug
resistance.
However,
many
commonly
used
photosensitizers
(PSs)
have
disadvantages
poor
water‐solubility
and
toxicity,
which
limits
their
clinical
application.
Additionally,
nitric
oxide
(NO)
has
unique
advantages
in
antibacterial
due
its
small
molecular
weight.
Herein,
protoporphyrin
IX
(PpIX),
L‐arginine
(L‐Arg),
glycol
chitosan
(GC)
are
construct
self‐assembled
cationic
Arg‐GC‐PpIX
nanoreactor
for
efficient
inactivation
under
white
light
illumination.
The
excellent
water
dispersity
stability
can
rapidly
bind
through
electrostatic
interaction
produce
local
singlet
oxygen
(
1
O
2
)/NO
irradiation,
leading
high
efficiency
toward
both
Gram‐negative
Gram‐positive
bacteria.
Besides,
these
NPs
also
possess
desirable
antibiofilm
ability.
Finally,
Arg‐GC‐PpIX@Gel
obtained
loading
into
sodium
alginate
(SA)/Ca
2+
hydrogel
shows
satisfactory
ability
promote
infected
wound
healing
when
combined
irradiation.
Therefore,
rationally
designed
light‐triggered
/NO
release
promising
agent
achieving
effective
PDT/NO
gas
therapy.
Language: Английский
Development of g-C3N4 Coated Eggshell Waste-Derived Ca(OH)2 Nanoparticles as a Photocatalyst for the Degradation of Eriochrome Cyanin R with Promising Antibacterial Activity
Journal of Inorganic and Organometallic Polymers and Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Language: Английский