BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications

Colorants, Journal Year: 2025, Volume and Issue: 4(2), P. 13 - 13

Published: April 2, 2025

BODIPY (Boron-Dipyrromethene) dyes have emerged as versatile fluorescent probes in cellular imaging and therapeutic applications owing to their unique chemical properties, including high fluorescence quantum yield, strong extinction coefficients, remarkable photostability. This review synthesizes the recent advancements dyes, focusing on deployment biological therapy. The exceptional ability of selectively stain structures enables precise visualization lipids, proteins, nucleic acids within live tumor cells, thereby facilitating enhanced understanding biochemical processes. Moreover, derivatives are increasingly utilized Photodynamic therapy (PDT) Photothermal therapies (PTT) for targeting cancer where capability generate cytotoxic reactive oxygen species upon light activation offers a promising approach treatment. Recently, been used Boron Neutron Capture Therapy (BNCT) various tumors, it is growing research field. Advancements nanotechnology allowed fabrication dye-based nanomedicines, either alone or with use metallic nanoparticles matrix offering development new class bioimaging theragnostic agents. also discusses innovative BODIPY-based formulations strategies that amplify efficacy while minimizing adverse effects, underscoring potential these integral components next-generation diagnostic modalities. By summarizing current future perspectives, this highlights critical importance advancing fields treatment methodologies.

Language: Английский

Recent Advances in Nano-Drug Delivery Strategies for Chalcogen–Based Therapeutic Agents in Cancer Phototherapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4819 - 4819

Published: May 17, 2025

Chalcogen–containing therapeutic agents (TAs), which include sulfur (S), selenium (Se), and tellurium (Te) atoms, have recently emerged as a promising class of photosensitizers (PSs) photothermal (PTAs) for cancer phototherapy. The incorporation heavier chalcogens into organic chromophores leads to visible–to–near–infrared (VIS–NIR) light absorption, efficient triplet harvesting, adequate heat energy transfer efficiency, all are paramount photodynamic therapy (PDT) (PTT). However, chalcogen–based PSs/PTAs suffer from photostability, bioavailability, targeted delivery issues, minimize their PDT/PTT performances. Nevertheless, significant progress in the rational design nanoencapsulation strategies has been achieved overcome challenges TAs effective phototherapeutic treatment. This review highlights recent advances (within last five years) nano-drug approaches adapted chalcogen–substituted PDT, PTT, or synergistic PDT/PTT, integrating imaging described this classified three classes: (i) sulfur, (ii) selenium, (iii) tellurium–containing used phototherapy applications. offers comprehensive perspective on (PTAs), covering spectroscopic computational characterization, nanoformulation strategies, roles enhancing reactive oxygen species (ROS) generation conversion efficiency improved vitro vivo performance. We hope work will encourage further research nanotechnological designed enhance efficacy chalcogen–containing agents.

Language: Английский

Near-infrared BODIPY-based theranostic agents for photothermal and combinatory therapy of cancers, where do we stand in year 2025

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216781 - 216781

Published: May 21, 2025

Language: Английский