Modified magnetic chitosan with mono(6-amino-6-deoxy)-β-cyclodextrin as a novel catalyst toward the synthesis of pyrazolopyranopyrimidines and pyrano[2,3-c]pyrazole-3-carboxylates

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 6, 2025

In this study, we successfully fabricated a novel biocomposite composed of 6-amino β-cyclodextrin (CDNH2) grafted onto magnetic chitosan (Fe3O4@Cs). This was thoroughly characterized using FT-IR, NMR, PXRD, EDX mapping, SEM, TEM, TGA, and VSM techniques. Subsequently, the innovative harnessed to serve as heterogeneous catalyst facilitate two series multicomponent reactions (MCRs) aimed at synthesizing pyrazole-fused heterocycle derivatives. The first reaction involved combination hydrazine hydrate, ethyl 3-oxobutanoate, barbituric acid, various benzaldehyde separate reaction, dimethyl acetylenedicarboxylate (DMAD), derivatives, malonitrile were used starting materials. By optimizing conditions employing Fe3O4@Cs@CDNH2 catalyst, synthesized valuable pyrazole structures with high yields in both reactions. ability optimize produce new impressive highlights effectiveness direct these

Language: Английский

Porous ionic copolymer-functionalized magnetic diatomite as a superior catalyst toward regioselective synthesis of pyridopyrimidines

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136695 - 136695

Published: March 1, 2025

Language: Английский