Polyethylene Glycolated Shikonin-Functionalized Carbon Nanotubes as an Effective Anticancer System Combining Chemotherapy and Photothermal Therapy DOI
Zhiyuan Liu,

Yaxuan Huang,

Rui Sun

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Shikonin (SHK) is a potential chemotherapy drug for the treatment of breast cancer. However, poor water solubility, as well lack tumor targeting, restricts practical application SHK molecules. In addition, alone no longer sufficient current clinical treatment, and it needs to be combined with other therapeutical methods. Here, using our previously developed shikonin-disulfide bond-poly(ethylene glycol) compound (referred SHK-SS-PEG) molecule that responds reduced glutathione (GSH), SHK-SS-PEG-functionalized multiwall carbon nanotubes (MWCNTs) system (SHK-SS-PEG/MWCNTs) was prepared by physical interaction. Such exhibits both photothermal therapy The adsorption SHK-SS-PEG on MWCNTs causes them have good dispersion storage stability up 3 months in aqueous solution possess excellent conversion performance MWCNTs. release rate SHK-SS-PEG/MWCNTs MCF-7 cells triggered near-infrared (NIR) laser increased 2-fold compared nonirradiated cells. vitro antitumor studies demonstrated had effect therapy. mortality treated ([MWCNTs] = 75 μg/mL) under 808 nm NIR irradiation high 87.78%, which 34.39% 28.31% higher than group without irradiated at same equivalent concentration, respectively. These results indicated an were ideal system.

Language: Английский

Polyethylene Glycolated Shikonin-Functionalized Carbon Nanotubes as an Effective Anticancer System Combining Chemotherapy and Photothermal Therapy DOI
Zhiyuan Liu,

Yaxuan Huang,

Rui Sun

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Shikonin (SHK) is a potential chemotherapy drug for the treatment of breast cancer. However, poor water solubility, as well lack tumor targeting, restricts practical application SHK molecules. In addition, alone no longer sufficient current clinical treatment, and it needs to be combined with other therapeutical methods. Here, using our previously developed shikonin-disulfide bond-poly(ethylene glycol) compound (referred SHK-SS-PEG) molecule that responds reduced glutathione (GSH), SHK-SS-PEG-functionalized multiwall carbon nanotubes (MWCNTs) system (SHK-SS-PEG/MWCNTs) was prepared by physical interaction. Such exhibits both photothermal therapy The adsorption SHK-SS-PEG on MWCNTs causes them have good dispersion storage stability up 3 months in aqueous solution possess excellent conversion performance MWCNTs. release rate SHK-SS-PEG/MWCNTs MCF-7 cells triggered near-infrared (NIR) laser increased 2-fold compared nonirradiated cells. vitro antitumor studies demonstrated had effect therapy. mortality treated ([MWCNTs] = 75 μg/mL) under 808 nm NIR irradiation high 87.78%, which 34.39% 28.31% higher than group without irradiated at same equivalent concentration, respectively. These results indicated an were ideal system.

Language: Английский

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