Leveraging the Shape Fidelity of 3D Printed Bone Scaffolds Through Architectural Tailoring of an Emulsion Ink: A Combined Experimental and Computational Analysis DOI Open Access
Sagnik Ghosh,

Shubham Shankar Mohol,

Anupama Datta

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Hierarchical porous, bioactive, and biocompatible scaffolds with customizable multi‐functionality are promising alternatives for autografts allografts in bone tissue engineering. Combining high internal phase emulsion (HIPE) templating additive manufacturing provides possibilities to produce such multiscale porous scaffolds. 3D printing of HIPE remains a challenging task due the intense separation under shear extrusion reported printability (P r ) either less than or greater 1. Tuning viscoelastic properties is therefore required achieve P ≈1. This study addresses these issues by preparing Pickering HIPEs using dual networks synergistic viscous elastic properties, stabilized Cloisite 30B interphase. configuration enhances viscoelasticity achieves values close 1 (0.98–1.02). The printed exhibit trabecular bone‐like, hierarchical interconnected porosity (77%–86%). Computational simulations accurately predict mechanical, biological, degradation behavior. Functionalization Cissus quadrangularis bioactivates scaffolds, demonstrates vivo biocompatibility, promotes MC3T3‐E1 adhesion, proliferation, accelerates osteogenesis, reduces oxidative stress compared neat PCL work introduces facile strategy “engineering printability” regenerative materials design holds potential developing optimized engineering

Language: Английский

Towards cell-adhesive, 4D printable PCL Networks through dynamic covalent chemistry DOI
Sagnik Ghosh, Sathiyaraj Subramaniyan,

Anadi Bisht

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In recent years, the development of biodegradable, cell-adhesive polymeric implants and minimally invasive surgery has significantly advanced healthcare. These materials exhibit multifunctional properties like self-healing, shape-memory, cell adhesion, which can be achieved through novel chemical approaches. Engineering such their scalability using a classical polymer network without complex synthesis modification been great challenge, potentially resolved biobased dynamic covalent chemistry (DCC). Here, we report scalable, self-healable, poly(ε-caprolactone) (PCL)-based vitrimer scaffold, imine exchange, free from limitations melting transitions supramolecular interactions in 4D-printed PCL. PCL's typical hydrophobicity hinders adhesion; however, our design, based on photopolymerization PCL-dimethacrylate methacrylate-terminated vanillin-based imine, achieves water contact angle 64°. The network, fabricated varying proportions, exhibited co-continuous phase morphology, achieving optimal shape fixity (91 ± 1.7%) recovery (92.5 0.1%) at physiological temperature (37 °C). Additionally, scaffold promoted adhesion proliferation reduced oxidative stress defect site. This material shows potential DCC-based research developing smart biomedical devices with geometries, paving way for applications regenerative medicine implant design.

Language: Английский

Citations

3
Development of Flexible Pressure Sensing Assembly of Biodegradable Polymers and Nanocomposite DOI Open Access

R. S. Panwar,

Sagnik Ghosh, Mukesh Bajya

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

ABSTRACT The wearable and flexible pressure sensors have gained significant attention due to their capability of transducing the physical phenomena like temperature into electrical signals. This study assessed feasibility poly(L‐lactide) (PLA) nanocomposite films prepared by solvent evaporation method integrated it with knitted cotton fabric for sensing application. Multiwalled carbon nanotubes (MWCNT), graphene oxide (GO), black (CB) individually in a tri‐mixture were used as nanofillers improve conductivity 2 wt.% PLA film. increasing loadings nanomaterials (0.1–8 individual 1–5 tri‐mixture) improved films. For nanomaterials, followed order, MWCNT>GO>CB. resistivity PLA‐nanocomposite films, that is, MWCNT‐1 wt.%, GO‐6 CB‐8 was 0.733 ± 0.02 kΩ cm, 200 0.53 276.25 1.26 respectively, whereas neat film 1760 40 cm. (PLA‐5) comprising 5 demonstrated lowest 160.727 3.94 Ω Further, PLA‐5 fabric, when assembled an circuit, acted electrically conducting material. Moreover, assembly varied changing levels, thus proving its suitability value change resistance ( R / 0 ) decreased from 11 3.5 on successive increase applied 50 150 kPa. Certainly, developed based is potentially suitable high areas such sports posture correction.

Language: Английский

Citations

0
Experimental Investigations into 4D Printing of Biocompatible Triple-Shape Memory Polymer Structures DOI

Shubham Shankar Mohol,

Doyel Ghosal,

Pulak M. Pandey

et al.

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
Leveraging the Shape Fidelity of 3D Printed Bone Scaffolds Through Architectural Tailoring of an Emulsion Ink: A Combined Experimental and Computational Analysis DOI Open Access
Sagnik Ghosh,

Shubham Shankar Mohol,

Anupama Datta

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Hierarchical porous, bioactive, and biocompatible scaffolds with customizable multi‐functionality are promising alternatives for autografts allografts in bone tissue engineering. Combining high internal phase emulsion (HIPE) templating additive manufacturing provides possibilities to produce such multiscale porous scaffolds. 3D printing of HIPE remains a challenging task due the intense separation under shear extrusion reported printability (P r ) either less than or greater 1. Tuning viscoelastic properties is therefore required achieve P ≈1. This study addresses these issues by preparing Pickering HIPEs using dual networks synergistic viscous elastic properties, stabilized Cloisite 30B interphase. configuration enhances viscoelasticity achieves values close 1 (0.98–1.02). The printed exhibit trabecular bone‐like, hierarchical interconnected porosity (77%–86%). Computational simulations accurately predict mechanical, biological, degradation behavior. Functionalization Cissus quadrangularis bioactivates scaffolds, demonstrates vivo biocompatibility, promotes MC3T3‐E1 adhesion, proliferation, accelerates osteogenesis, reduces oxidative stress compared neat PCL work introduces facile strategy “engineering printability” regenerative materials design holds potential developing optimized engineering

Language: Английский

Citations

0