Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(7), P. 3124 - 3138
Published: Feb. 16, 2022
Tumor-associated
macrophages
(TAMs),
one
of
the
dominating
constituents
tumor
microenvironment,
are
important
contributors
to
cancer
progression
and
treatment
resistance.
Therefore,
regulation
TAMs
polarization
from
M2
phenotype
towards
M1
has
emerged
as
a
new
strategy
for
immunotherapy.
Herein,
we
successfully
initiated
antitumor
immunotherapy
by
inhibiting
via
autophagy
intervention
with
polyethylene
glycol-conjugated
gold
nanoparticles
(PEG-AuNPs).
PEG-AuNPs
suppressed
in
both
vitro
vivo
models,
elicited
inhibited
subcutaneous
growth
mice.
As
demonstrated
mRFP-GFP-LC3
assay
analyzing
autophagy-related
proteins
(LC3,
beclin1
P62),
induced
autophagic
flux
inhibition
TAMs,
which
is
attributed
lysosome
alkalization
membrane
permeabilization.
Besides,
were
prone
polarize
following
activation,
whereas
could
reduce
TAMs.
Our
results
revealed
mechanism
underlying
immunotherapy,
where
induction
dysfunction
inhibition.
This
study
elucidated
biological
effects
nanomaterials
on
provided
insight
into
harnessing
intrinsic
immunomodulation
capacity
effective
treatment.
Journal of King Saud University - Science,
Journal Year:
2022,
Volume and Issue:
34(3), P. 101869 - 101869
Published: Jan. 29, 2022
In
terms
of
cost-efficiency,
biocompatibility,
environmental
friendliness,
and
scalability,
green
nanoparticle
(NP)
synthesis
is
a
novel
field
nanotechnology
that
outperforms
both
physical
chemical
approaches.
Plants,
bacteria,
fungi,
algae
have
lately
been
used
to
produce
metals
metal
oxide
nanoparticles
as
an
alternate
method.
The
development
alternative
strategies
restrict
the
growth
hazardous
well
building
resistance
by
germs
various
antibiotics,
led
introduction
antimicrobial
agents.
Metal
oxides
found
form
monolayer
structures
for
drug
delivery
when
they
react
with
transporter's
surface.
emerged
biomedical
materials
in
recent
years,
applications
immunotherapy,
tissue
treatment,
diagnostics,
regenerative
medicine,
wound
healing,
dentistry,
biosensing
platforms.
Biotoxicology
its
antimicrobial,
antifungal,
antiviral
characteristics
were
hotly
contested.
tremendous
applicability
commercial
value,
evidenced
important
discoveries
realm
nanobiomedicine
locations
amounts.
This
paper
describes
production
nanometal
from
materials,
their
applications.
Nanomaterials,
Journal Year:
2020,
Volume and Issue:
10(6), P. 1086 - 1086
Published: May 31, 2020
Zinc
oxide
(ZnO)
is
a
multifunctional
material
due
to
its
exceptional
physicochemical
properties
and
broad
usefulness.
The
special
resulting
from
the
reduction
of
size
macro
scale
nano
has
made
application
ZnO
nanomaterials
(ZnO
NMs)
more
popular
in
numerous
consumer
products.
In
recent
years,
particular
attention
been
drawn
development
various
methods
NMs
synthesis,
which
above
all
meet
requirements
green
chemistry
approach.
microwave
heating
technology
when
obtaining
enables
new
syntheses,
are
characterised
by,
among
others,
possibility
control
properties,
repeatability,
reproducibility,
short
synthesis
duration,
low
price,
purity,
fulfilment
eco-friendly
approach
criterion.
dynamic
materials
engineering
reason
why
it
necessary
obtain
with
strictly
defined
properties.
present
review
aims
discuss
state
art
regarding
undoped
doped
NMs.
first
part
presents
applications
Subsequently,
discussed
compared
conventional
areas
presented.
final
paper
reactants,
parameters
processes,
morphology
products,
division
into
three
primary
groups,
namely
hydrothermal,
solvothermal,
hybrid
methods.
Environmental Chemistry Letters,
Journal Year:
2020,
Volume and Issue:
19(1), P. 583 - 611
Published: Sept. 16, 2020
Abstract
The
inert
nature
of
most
commercial
polymers
and
nanomaterials
results
in
limitations
applications
various
industrial
fields.
This
can
be
solved
by
surface
modifications
to
improve
physicochemical
biological
properties,
such
as
adhesion,
printability,
wetting
biocompatibility.
Polymer
functionalization
allows
graft
specific
moieties
conjugate
molecules
that
material
performances.
In
the
last
decades,
several
approaches
have
been
designed
industry
academia
functional
groups
on
surfaces.
Here,
we
review
decoration
nanomaterials,
with
focus
major
medical
field,
textile
industry,
water
treatment
food
packaging.
We
discuss
advantages
challenges
polymer
functionalization.
More
knowledge
is
needed
biology
behind
cell–polymer
interactions,
nanosafety
manufacturing
at
scale.
Critical reviews in solid state and materials sciences/CRC critical reviews in solid state and materials sciences,
Journal Year:
2020,
Volume and Issue:
46(5), P. 385 - 449
Published: Oct. 6, 2020
Two
dimensional
(2D)
graphene
and
its
derivatives
modification
with
nanomaterials
for
formation
of
hybrid/nanocomposites
undergo
stimulus-induced
optical
electrical
changes
which
are
important
many
new
switchable
device
technologies.
The
feature
article
deals
a
straight
forward
versatile
technique
the
fabrication
semiconductor
(CdS
TiO2)
dispersed
liquid
crystals
(NDLC)
or
crystal
(GDLC)
by
stretching
hydrogen
bonds
(H-)
in
precursor
droplets
between
two
substrates
to
form
bridge.
Fewer
(LCs)
possess
conventional
oriented
nematic
phase
optimal
performances.
Evolving
advantages
thin-film
nanocomposite
materials
devices
have
fueled
several
developments
field
flexible
electronics,
high
contrast
ratio
smart
display
opto-electronics.
These
been
complemented
expansion
novel
composite
such
as
GDLC
NDLC
sensors
monitor
inflammability,
explosive
nature
toxicity
chemicals.
This
discussion
also
delves
into
assembly
polymer
nanocomposites
LCs,
necessity
bio-polymer
incorporation
their
bio-sensing
antimicrobial
applications.
Additionally,
discussed
issues
challenges
associated
understanding
exploiting
potentials
fabricated
polymer/graphene
hybrid
matrix.
Following
substantial
development
optimized
over
decades,
mechanism
employed
via
matrix
has
found
offer
numerous
benefits
including
being
cost-effective,
possessing
large
area
compatibility
scalability
addition
seamless
heterogeneous
integration.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
155, P. 113658 - 113658
Published: Sept. 23, 2022
Anti-microbial
resistance
(AMR)
has
recently
emerged
as
an
area
of
high
interest
owing
to
the
rapid
surge
AMR
phenotypes.
Metal
oxide
NPs
(MeONPs)
have
been
identified
novel
phytomedicine
and
peaked
a
lot
due
their
potential
applications
in
combating
phytopathogens,
besides
enhancing
plant
growth
yields.
Numerous
MeONPs
(Ti2O,
MgO,
CuO,
Ag2O,
SiO2,
ZnO,
CaO)
synthesized
tested
validate
antimicrobial
roles
without
causing
toxicity
cells.
This
review
discusses
application
with
special
emphasis
on
anti-microbial
activities
agriculture
enlists
how
cellular
caused
through
reactive
oxygen
species
(ROS)
production
affects
growth,
morphology,
viability.
further
highlights
two-facet
role
silver
copper
including
toxicities.
Furthermore,
factor
modulating
nanotoxicity
immunomodulation
for
cytokine
also
discussed.
Thus,
this
article
will
not
only
provide
researchers
bottlenecks
but
emphasizes
comprehensive
outline
breakthroughs
applicability
agriculture.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(8), P. 4249 - 4249
Published: April 12, 2022
The
drugs
used
for
cancer
treatment
have
many
drawbacks,
as
they
damage
both
tumor
and
healthy
cells
and,
in
addition,
tend
to
be
poorly
soluble
drugs.
Their
transport
nanoparticles
can
solve
these
problems
release
the
drug
into
tissues,
well
improve
their
solubility,
bioavailability,
efficacy,
reducing
adverse
effects.
This
article
focuses
on
advantages
that
nanotechnology
bring
medicine,
with
special
emphasis
nanoliposomes.
For
this,
a
review
has
been
made
of
nanoliposomal
systems
marketed
cancer,
those
are
research
phase,
highlighting
clinical
trials
being
carried
out.
All
liposomes
studied
intravenously
administered,
showing
reduced
intensity
side-effects
compared
nonliposomal
form.
Doxorubicin
is
active
ingredient
most
frequently
employed.
Ongoing
expand
availability
liposomal
medicines
new
indications.
In
conclusion,
introduction
nanoliposomes
means
an
improvement
efficacy
quality
life
patients.
future
focus
could
directed
develop
multifunctional
targeted
using
anticancer
drugs,
different
types
existing
or
standardized
methodologies
easily
translated
industrial
scale.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: June 28, 2023
At
present,
iron
oxide
nanoparticles
(IONPs)
are
widely
used
in
the
biomedical
field.
They
have
unique
advantages
targeted
drug
delivery,
imaging
and
disease
treatment.
However,
there
many
things
to
pay
attention
to.
In
this
paper,
we
reviewed
fate
of
IONPs
different
cells
influence
on
production,
separation,
delivery
treatment
extracellular
vesicles.
It
aims
provide
cutting-edge
knowledge
related
nanoparticles.
Only
by
ensuring
safety
effectiveness
can
their
application
research
clinic
be
further
improved.