Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization DOI Creative Commons
Siyue Zhang,

Fangyuan Xie,

Kaichun Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(7), P. 3124 - 3138

Published: Feb. 16, 2022

Tumor-associated macrophages (TAMs), one of the dominating constituents tumor microenvironment, are important contributors to cancer progression and treatment resistance. Therefore, regulation TAMs polarization from M2 phenotype towards M1 has emerged as a new strategy for immunotherapy. Herein, we successfully initiated antitumor immunotherapy by inhibiting via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles (PEG-AuNPs). PEG-AuNPs suppressed in both vitro vivo models, elicited inhibited subcutaneous growth mice. As demonstrated mRFP-GFP-LC3 assay analyzing autophagy-related proteins (LC3, beclin1 P62), induced autophagic flux inhibition TAMs, which is attributed lysosome alkalization membrane permeabilization. Besides, were prone polarize following activation, whereas could reduce TAMs. Our results revealed mechanism underlying immunotherapy, where induction dysfunction inhibition. This study elucidated biological effects nanomaterials on provided insight into harnessing intrinsic immunomodulation capacity effective treatment.

Language: Английский

Biological agents for synthesis of nanoparticles and their applications DOI Creative Commons
Chetan Pandit, Arpita Roy, Suresh Ghotekar

et al.

Journal of King Saud University - Science, Journal Year: 2022, Volume and Issue: 34(3), P. 101869 - 101869

Published: Jan. 29, 2022

In terms of cost-efficiency, biocompatibility, environmental friendliness, and scalability, green nanoparticle (NP) synthesis is a novel field nanotechnology that outperforms both physical chemical approaches. Plants, bacteria, fungi, algae have lately been used to produce metals metal oxide nanoparticles as an alternate method. The development alternative strategies restrict the growth hazardous well building resistance by germs various antibiotics, led introduction antimicrobial agents. Metal oxides found form monolayer structures for drug delivery when they react with transporter's surface. emerged biomedical materials in recent years, applications immunotherapy, tissue treatment, diagnostics, regenerative medicine, wound healing, dentistry, biosensing platforms. Biotoxicology its antimicrobial, antifungal, antiviral characteristics were hotly contested. tremendous applicability commercial value, evidenced important discoveries realm nanobiomedicine locations amounts. This paper describes production nanometal from materials, their applications.

Language: Английский

Citations

314

A Review of Microwave Synthesis of Zinc Oxide Nanomaterials: Reactants, Process Parameters and Morphologies DOI Creative Commons
Jacek Wojnarowicz, Tadeusz Chudoba, Witold Łojkowski

et al.

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(6), P. 1086 - 1086

Published: May 31, 2020

Zinc oxide (ZnO) is a multifunctional material due to its exceptional physicochemical properties and broad usefulness. The special resulting from the reduction of size macro scale nano has made application ZnO nanomaterials (ZnO NMs) more popular in numerous consumer products. In recent years, particular attention been drawn development various methods NMs synthesis, which above all meet requirements green chemistry approach. microwave heating technology when obtaining enables new syntheses, are characterised by, among others, possibility control properties, repeatability, reproducibility, short synthesis duration, low price, purity, fulfilment eco-friendly approach criterion. dynamic materials engineering reason why it necessary obtain with strictly defined properties. present review aims discuss state art regarding undoped doped NMs. first part presents applications Subsequently, discussed compared conventional areas presented. final paper reactants, parameters processes, morphology products, division into three primary groups, namely hydrothermal, solvothermal, hybrid methods.

Language: Английский

Citations

293

Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review DOI Creative Commons
Pooyan Makvandi, Sidra Iftekhar, Fabio Pizzetti

et al.

Environmental Chemistry Letters, Journal Year: 2020, Volume and Issue: 19(1), P. 583 - 611

Published: Sept. 16, 2020

Abstract The inert nature of most commercial polymers and nanomaterials results in limitations applications various industrial fields. This can be solved by surface modifications to improve physicochemical biological properties, such as adhesion, printability, wetting biocompatibility. Polymer functionalization allows graft specific moieties conjugate molecules that material performances. In the last decades, several approaches have been designed industry academia functional groups on surfaces. Here, we review decoration nanomaterials, with focus major medical field, textile industry, water treatment food packaging. We discuss advantages challenges polymer functionalization. More knowledge is needed biology behind cell–polymer interactions, nanosafety manufacturing at scale.

Language: Английский

Citations

184

Cutting edge development on graphene derivatives modified by liquid crystal and CdS/TiO2hybrid matrix: optoelectronics and biotechnological aspects DOI
Kaushik Pal,

Asiya SI,

Gharieb S. El‐Sayyad

et al.

Critical reviews in solid state and materials sciences/CRC critical reviews in solid state and materials sciences, Journal Year: 2020, Volume and Issue: 46(5), P. 385 - 449

Published: Oct. 6, 2020

Two dimensional (2D) graphene and its derivatives modification with nanomaterials for formation of hybrid/nanocomposites undergo stimulus-induced optical electrical changes which are important many new switchable device technologies. The feature article deals a straight forward versatile technique the fabrication semiconductor (CdS TiO2) dispersed liquid crystals (NDLC) or crystal (GDLC) by stretching hydrogen bonds (H-) in precursor droplets between two substrates to form bridge. Fewer (LCs) possess conventional oriented nematic phase optimal performances. Evolving advantages thin-film nanocomposite materials devices have fueled several developments field flexible electronics, high contrast ratio smart display opto-electronics. These been complemented expansion novel composite such as GDLC NDLC sensors monitor inflammability, explosive nature toxicity chemicals. This discussion also delves into assembly polymer nanocomposites LCs, necessity bio-polymer incorporation their bio-sensing antimicrobial applications. Additionally, discussed issues challenges associated understanding exploiting potentials fabricated polymer/graphene hybrid matrix. Following substantial development optimized over decades, mechanism employed via matrix has found offer numerous benefits including being cost-effective, possessing large area compatibility scalability addition seamless heterogeneous integration.

Language: Английский

Citations

162

Response Surface Methodology Optimization of Mono-dispersed MgO Nanoparticles Fabricated by Ultrasonic-Assisted Sol–Gel Method for Outstanding Antimicrobial and Antibiofilm Activities DOI

Chiew Wee Wong,

Yen San Chan, Jaison Jeevanandam

et al.

Journal of Cluster Science, Journal Year: 2019, Volume and Issue: 31(2), P. 367 - 389

Published: Aug. 13, 2019

Language: Английский

Citations

158

Recent advances of chitosan-based nanoparticles for biomedical and biotechnological applications DOI
Yanyun Gao, WU Yu-ling

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 203, P. 379 - 388

Published: Jan. 29, 2022

Language: Английский

Citations

125

The emergence of metal oxide nanoparticles (NPs) as a phytomedicine: A two-facet role in plant growth, nano-toxicity and anti-phyto-microbial activity DOI Open Access
Rahul Bhattacharjee, Lamha Kumar, Nobendu Mukerjee

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113658 - 113658

Published: Sept. 23, 2022

Anti-microbial resistance (AMR) has recently emerged as an area of high interest owing to the rapid surge AMR phenotypes. Metal oxide NPs (MeONPs) have been identified novel phytomedicine and peaked a lot due their potential applications in combating phytopathogens, besides enhancing plant growth yields. Numerous MeONPs (Ti2O, MgO, CuO, Ag2O, SiO2, ZnO, CaO) synthesized tested validate antimicrobial roles without causing toxicity cells. This review discusses application with special emphasis on anti-microbial activities agriculture enlists how cellular caused through reactive oxygen species (ROS) production affects growth, morphology, viability. further highlights two-facet role silver copper including toxicities. Furthermore, factor modulating nanotoxicity immunomodulation for cytokine also discussed. Thus, this article will not only provide researchers bottlenecks but emphasizes comprehensive outline breakthroughs applicability agriculture.

Language: Английский

Citations

83

Nanoliposomes in Cancer Therapy: Marketed Products and Current Clinical Trials DOI Open Access
Raquel Taléns‐Visconti, Octavio Dı́ez-Sales, Jesús Vicente de Julián-Ortiz

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4249 - 4249

Published: April 12, 2022

The drugs used for cancer treatment have many drawbacks, as they damage both tumor and healthy cells and, in addition, tend to be poorly soluble drugs. Their transport nanoparticles can solve these problems release the drug into tissues, well improve their solubility, bioavailability, efficacy, reducing adverse effects. This article focuses on advantages that nanotechnology bring medicine, with special emphasis nanoliposomes. For this, a review has been made of nanoliposomal systems marketed cancer, those are research phase, highlighting clinical trials being carried out. All liposomes studied intravenously administered, showing reduced intensity side-effects compared nonliposomal form. Doxorubicin is active ingredient most frequently employed. Ongoing expand availability liposomal medicines new indications. In conclusion, introduction nanoliposomes means an improvement efficacy quality life patients. future focus could directed develop multifunctional targeted using anticancer drugs, different types existing or standardized methodologies easily translated industrial scale.

Language: Английский

Citations

77

Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment DOI
Yuzhi Jin,

Yangyue Huang,

Hui Ren

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 305, P. 122463 - 122463

Published: Jan. 6, 2024

Language: Английский

Citations

49

Recent progress in the effect of magnetic iron oxide nanoparticles on cells and extracellular vesicles DOI Creative Commons
Yuling Chen, Shike Hou

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: June 28, 2023

At present, iron oxide nanoparticles (IONPs) are widely used in the biomedical field. They have unique advantages targeted drug delivery, imaging and disease treatment. However, there many things to pay attention to. In this paper, we reviewed fate of IONPs different cells influence on production, separation, delivery treatment extracellular vesicles. It aims provide cutting-edge knowledge related nanoparticles. Only by ensuring safety effectiveness can their application research clinic be further improved.

Language: Английский

Citations

45