Biomedical application of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targeted delivery, phototherapy and diagnosis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129391 - 129391

Published: Jan. 20, 2024

Language: Английский

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Unveiling the potential of HKUST-1: synthesis, activation, advantages and biomedical applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2670 - 2690

Published: Jan. 1, 2024

HKUST-1 represents a promising biomaterial, functioning not only as drug carrier but also releasing bioactive copper ions, thereby demonstrating exceptional antitumor, antibacterial, and wound healing properties.

Language: Английский

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In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 660, P. 637 - 646

Published: Jan. 21, 2024

Language: Английский

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Metal‐Organic Framework‐Based Nanomedicines for Ferroptotic Cancer Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 14, 2024

Abstract As an iron‐dependent, non‐apoptosis, regulated cell death (RCD) modality, ferroptosis has gained growing attention for cancer therapy. With the development of nanomaterials in biomedical field, ferroptotic nanomedicine is extensively investigated. Amongst various nanomaterials, metal‐organic frameworks (MOFs) are hybridized porous materials consisting metal ions or clusters bridged by organic linkers. The superior properties MOFs, such as high porosity and cargo loading, ease surface modification, good biocompatibility, make them appealing inducing sensitizing death. There remarkable achievements field MOF‐based However, this topic not reviewed. This review will introduce fundamentals MOF machinery, summarize recent progress anticancer drug delivery, discuss benefits problems MOFs vehicles sensitizers ferroptosis, provide perspective on future research direction promising field.

Language: Английский

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Copper homeostasis and cuproptosis in tumor pathogenesis and therapeutic strategies

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 12, 2023

Copper is an indispensable micronutrient for the development and replication of all eukaryotes, its redox properties are both harmful beneficial to cells. An imbalance in copper homeostasis thought be involved carcinogenesis. Importantly, cancer cell proliferation, angiogenesis, metastasis cannot separated from effects copper. Cuproposis a copper-dependent form death that differs other existing modalities regulatory death. The role cuproptosis pathogenesis nervous cardiovascular systems has been widely studied; however, impact on malignant tumors yet fully understood clinical perspective. Exploring signaling pathways related will undoubtedly provide new perspective anti-tumor drugs future. Here, we systematically review systemic cellular metabolic processes mechanisms cancer. In addition, discuss possibility targeting ion prolong survival patients, with emphasis most representative ionophores chelators. We suggest attention should paid potential value treatment specific cancers.

Language: Английский

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Oxidative Stress in Melanoma: Beneficial Antioxidant and Pro-Oxidant Therapeutic Strategies

Cancers, Journal Year: 2023, Volume and Issue: 15(11), P. 3038 - 3038

Published: June 2, 2023

Cutaneous melanoma ranks as the fifth most common cancer in United States and represents one of deadliest forms skin cancer. While recent advances systemic targeted therapies immunotherapies have positively impacted survival, survival rate stage IV remains at a meager 32%. Unfortunately, tumor resistance can impede effectiveness these treatments. Oxidative stress is pivotal player all stages progression, with somewhat paradoxical function that promotes initiation but hinders vertical growth metastasis later disease. As progresses, it employs adaptive mechanisms to lessen oxidative environment. Redox metabolic rewiring has been implicated acquired BRAF/MEK inhibitors. A promising approach enhance response therapy involves boosting intracellular ROS production using active biomolecules or targeting enzymes regulate stress. The complex interplay between stress, redox homeostasis, melanomagenesis also be leveraged preventive context. purpose this review provide an overview melanoma, how antioxidant system may manipulated therapeutic context for improved efficacy survival.

Language: Английский

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Ferroptosis as a promising therapeutic strategy for melanoma

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 19, 2023

Malignant melanoma (MM) is the most common and deadliest type of skin cancer associated with high mortality rates across all races ethnicities. Although present treatment options combined surgery provide short-term clinical benefit in patients early diagnosis non-metastatic MM significantly increases probability survival, no efficacious treatments are available for MM. The etiology pathogenesis complex. Acquired drug resistance a pool prognosis advanced-stage Thus, these require new therapeutic strategies to improve their response prognosis. Multiple studies have revealed that ferroptosis, non-apoptotic form regulated cell death (RCD) characterized by iron dependant lipid peroxidation, can prevent development Recent indicated targeting ferroptosis promising strategy This review article summarizes core mechanisms underlying cells its potential role as target We emphasize emerging types small molecules inducing pathways boosting antitumor activity BRAFi immunotherapy uncover beneficial effects treat also summarize application nanosensitizer-mediated unique dynamic ferroptosis-based nanodrug suggests pharmacological induction may be

Language: Английский

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Cuproptosis in cancer: biological implications and therapeutic opportunities

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: June 25, 2024

Abstract Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known death pathways. The molecular underpinnings cuproptosis involve the binding Cu lipoylated enzymes in tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating death. specific has yet be fully elucidated. recognized sparked numerous investigations into role tumorigenesis cancer therapy. In this review, we summarized current knowledge on metabolism link cancer. Furthermore, delineated mechanisms roles cuproptosis-related genes Finally, offered comprehensive discussion most recent advancements ionophores nanoparticle delivery systems utilize as cutting-edge strategy for treatment.

Language: Английский

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Molecular and therapeutic landscape of ferroptosis in skin diseases

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: 137(15), P. 1777 - 1789

Published: July 8, 2024

Regulated cell death (RCD) is a critical physiological process essential in maintaining skin homeostasis. Among the various forms of RCD, ferroptosis stands out due to its distinct features iron accumulation, lipid peroxidation, and involvement inhibitory antioxidant systems. In recent years, an expanding body research has solidly linked emergence disorders. Therefore, understanding mechanisms underlying diseases crucial for advancing therapy prevention strategies. This review commences with succinct elucidation that underpin ferroptosis, embarks on thorough exploration ferroptosis's role across spectrum conditions, encompassing melanoma, psoriasis, systemic lupus erythematosus (SLE), vitiligo, dermatological ailments precipitated by ultraviolet (UV) exposure, scrutinizes potential therapeutic benefits pharmacological interventions aimed at modulating amelioration diseases.

Language: Английский

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Recent advances in copper homeostasis-involved tumor theranostics

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100948 - 100948

Published: Sept. 7, 2024

As the third essential trace element in human body, copper plays a crucial role various physiological processes, which lays foundation for its broad applications cancer treatments. The overview of copper, including pharmacokinetics, signaling pathways, and homeostasis dysregulation, is hereby discussed. Additionally, cuproptosis, as newly proposed cell death mechanism associated with accumulation, analyzed further developed efficient treatment. Different forms Cu-based nanoparticles their advantages, well limiting factors, are introduced. Moreover, unique characteristics give rise to imaging modalities. In addition, nanomaterials featured by excellent photothermal property ROS-associated tumor-killing potential, widely explored diverse therapies combined therapies. Reducing concentration Cu

Language: Английский

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