Hemostatic nanofibers/chitosan composite aerogel for potential chemo-photothermal therapy DOI

Yijun Fu,

Chaowei Li, Chi Chen

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1319, P. 139477 - 139477

Published: July 27, 2024

Language: Английский

Unveiling intricating roles and mechanisms of ferroptosis in melanoma DOI
Tao Rui,

Yichuan Li,

Song Gong

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1880(1), P. 189234 - 189234

Published: Dec. 5, 2024

Language: Английский

Citations

2
ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating DOI Creative Commons
Bulat A. Faizullin, Irina R. Dayanova, Alexey V. Kurenkov

et al.

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Oct. 30, 2023

The work presents core-shell nanoparticles (NPs) built from the novel Cu(I) complexes with cyclic P2N2-ligands (1,5-diaza-3,7-diphosphacyclooctanes) that can visualize their entry into cancer and normal cells using a luminescent signal treat by self-enhancing generation of reactive oxygen species (ROS). Variation P- N-substituents in series allows structure optimization for formation NPs high chemical stability. non-covalent modification triblock copolymer F-127 provides colloidal stability, followed efficient cell internalization visualized blue (⁓450 nm) luminescence. cytotoxic effects toward some are significantly lower than those corresponding molecular complexes, which correlates stability solutions. ability to self-enhanced H2O2-induced ROS is demonstrated solutions intracellular space means standard electron spin resonance (ESR) fluorescence techniques correspondingly. anticancer specificity HuTu 80 apoptotic death pathway correlate level ROS, agrees well NPs. enhanced revealed incubated be associated significant mitochondrial localization.

Language: Английский

Citations

6
Harnessing the Potential of Non-Apoptotic Cell Death Processes in the Treatment of Drug-Resistant Melanoma DOI Open Access
Linyinxue Dong,

Ceeane Paul Dagoc Vargas,

Xuechen Tian

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10376 - 10376

Published: June 20, 2023

Melanoma is a highly malignant skin cancer that known for its resistance to treatments. In recent years, there has been significant progress in the study of non-apoptotic cell death, such as pyroptosis, ferroptosis, necroptosis, and cuproptosis. This review provides an overview mechanisms signaling pathways involved death melanoma. article explores interplay between various forms including cuproptosis, well apoptosis autophagy. Importantly, we discuss how these deaths could be targeted promising therapeutic strategy treatment drug-resistant comprehensive processes gathers experimental evidence will guide future research eventually creation strategies combat drug

Language: Английский

Citations

5
Iron-chelated and GSH-responsive polymersome nanoreactors facilitating therapeutic cascade reactions in cooperative starvation-ferroptosis therapy DOI
Yu‐Lun Lo, Venkatesh Ravula,

Feng-Shuo Yang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105916 - 105916

Published: June 26, 2024

Language: Английский

Citations

1
Hemostatic nanofibers/chitosan composite aerogel for potential chemo-photothermal therapy DOI

Yijun Fu,

Chaowei Li, Chi Chen

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1319, P. 139477 - 139477

Published: July 27, 2024

Language: Английский

Citations

0