Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 20, 2024

Abstract Oxidative stress (OS) is one of the crucial molecular events secondary spinal cord injury (SCI). Basic fibroblast growth factor (bFGF) a multipotent cell with an anti‐oxidant effect. However, bFGF has short half‐life in vivo, which limits its therapeutic application. Biodegradable polymers excellent biocompatibility have been recently applied SCI. The negative aspect that cannot provide significant Betulinic acid (BA), natural anti‐inflammatory compound, polymerized into poly (betulinic acid) (PBA) to serve as drug carrier for bFGF. This study explores effects and underlying mechanisms PBA nanoparticles (NPs) loaded (PBA‐bFGF NPs) Results show PBA‐bFGF NPs produce remarkable vivo vitro. results also demonstrate local delivery enhances motor function recovery, inhibits OS, mitigates neuroinflammation, alleviates neuronal apoptosis following Furthermore, indicate activates nuclear erythroid 2‐related 2 (Nrf‐2) signaling pathway In summary, suggest delivers potential advantages treatment management

Language: Английский

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An Overview on Bioactive Glasses for Bone Regeneration and Repair: Preparation, Reinforcement, and Applications

Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Synthetic bone transplantation has emerged in recent years as a highly promising strategy to address the major clinical challenge of tissue defects. In this field, bioactive glasses (BGs) have been widely recognized viable alternative traditional substitutes due their unique advantages, including favorable biocompatibility, pronounced bioactivity, excellent biodegradability, and superior osseointegration properties. This article begins with comprehensive overview development success BGs engineering, then focuses on composite reinforcement systems biodegradable metals, calcium-phosphorus (Ca-P)-based bioceramics, medical polymers, respectively. Moreover, outlines some frequently used manufacturing methods for three-dimensional BG-based bioscaffolds highlights remarkable achievements these scaffolds field defect repair years. Lastly, based many potential challenges encountered preparation application BGs, brief outlook future directions is presented. review may help provide new ideas researchers develop ideal reconstruction functional recovery.

Language: Английский

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Applications of Magnetic Nanocomposites and Their Role in Advancing Lateral Flow Assays

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(7)

Published: Feb. 1, 2025

Abstract This article explores the wide‐ranging applications of magnetic nanocomposites and their critical role in advancing lateral flow assays (LFAs) as diagnostic tools. We begin by reviewing a diverse array nanomaterials, including plasmonic, polymer, carbon, silica‐based nanocomposites, well notable examples such CoFe₂O₄, quantum dots, lipid‐based nanoparticles, hydrogels, metal–organic frameworks (MOFs), superparamagnetic iron oxide nanoparticles (SPIONs), gold nanorods. Each type nanocomposite is examined for its unique properties significant potential enhancing sensitivity, stability, multifunctionality. These are used across various sectors, medical diagnostics, environmental monitoring, imaging technology, where they contribute to improved signal strength, binding affinity, biocompatibility. The focuses specifically on application LFAs. rely nanoparticles’ interactions with target molecules achieve detection, providing promising platform point‐of‐care diagnostics. integration enhances detection limits, improves precision, reduces response times, making them an invaluable component rapid tests. By embedding into LFAs, researchers clinicians can more reliable accurate results, facilitating early diagnosis ultimately improving patient outcomes. Their LFAs demonstrates applications, from disease real‐time suggesting transformative impact diagnostics beyond.

Language: Английский

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Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2813 - 2846

Published: March 1, 2025

Abstract: Metal-based nanoparticles (MNPs) have great potential for applications in wound healing and tissue engineering, due to their unique structures, high bioactivities, excellent designability characteristics, an increasing number of studies been devoted modifying these species generate novel composites with desirable optical, electrical, magnetic properties. However, few systematic detailed reviews performed relating the modification approaches available MNPs resulting composites. In this review, a comprehensive summary is regarding optimized formulations application dressings, techniques used prepare composite dressings are discussed. addition, safety profiles nanocomposite limitations reported systems evaluated. More importantly, solution strategies proposed address limitations. Overall, review provides new ideas design facilitate field skin repair, also looks into future direction biomedical field. Keywords: metal-based nanoparticles, nanocomposite, dressing, multi-functional,

Language: Английский

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Study of anti-Toxoplasma gondii effect of mPEG–PCL copolymeric loaded with pyrimethamine, in vitro

AMB Express, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 2, 2025

Abstract The discovery of new drugs with minimal toxicity is crucially important in the search for effective treatments toxoplasmosis. study aimed to assess effectiveness pyrimethamine-loaded mPEG–PCL copolymeric nanoparticles (mPEG–PCL–Pyr) against Toxoplasma gondii ( T. ) tachyzoites. were fabricated using a nano-precipitation method and characterized DLS AFM. Through MTT assay, anti-toxoplasmic activity was gauged. Healthy infected cell viability, infection index, proliferation plaque count, size evaluated. Results indicated maximum drug loading capacity 11.23% nanoparticles. Toxicity testing on Vero cells tachyzoites revealed notable cytotoxic effects at pyrimethamine-equivalent concentrations 20 40 mg/mL nanoparticle formulation. However, as results indicated, administration mPEG–PCL–Pyr resulted reduction intracellular proliferation, number plaques comparison uninfected treated P < 0.05). synthesized Nano exhibited slightly better performance than pyrimethamine, despite lack statistical significance observed distinction p > demonstrated that containing pyrimethamine effectively impede vitro replication . impact resembled nano-drug tachyzoites, suggesting potential these promising avenue toxoplasmosis treatment.

Language: Английский

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Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 055016 - 055016

Published: June 25, 2024

This study was designed to deposit nanodiamonds (NDs) on 3D-printed poly-

Language: Английский

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Enhancing thermal and mechanical properties of polycaprolactone nanofibers with graphene and graphene oxide reinforcement for biomedical applications

Matéria (Rio de Janeiro), Journal Year: 2024, Volume and Issue: 29(3)

Published: Jan. 1, 2024

This study aimed to enhance the mechanical, thermal, and biocompatibility properties of polycaprolactone (PCL) nanocomposite nanofibers by incorporating graphene oxide (GO) using electrospinning technique. PCL were synthesized with varying concentrations (0.5%, 1%, 1.5%) GO 1.5%). Mechanical evaluated through tensile strength tests, showing significant enhancements. Graphene increased 10%, 20%, 30%, while improved it 15%, 25%, 35% for respective concentrations. Thermal stability was assessed via thermogravimetric analysis (TGA), revealing that onset degradation temperature 5%, 15% 7%, 12%, 18% GO. The maximum weight loss up 20% GO-reinforced nanocomposites. Results indicated enhanced cell viability 8%, 20%. thermal improvements attributed better dispersion stronger interfacial bonding within matrix. nanocomposites showed a improvement in viability, suggesting their suitability biomedical applications. These findings indicate significantly enhances nanocomposites, making them suitable demanding

Language: Английский

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Synthesis of 1,2,4-triazole-based deep eutectic solvents modified nickel ferrite nanoparticles and their application in dispersive solid phase extraction of triazole pesticides prior to LC-MS/MS analysis

Talanta, Journal Year: 2024, Volume and Issue: 283, P. 127050 - 127050

Published: Oct. 25, 2024

Language: Английский

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Exploring the phenomena of dispersion and electrical properties of natural montmorillonite particles in polyamide 6 as a nanocomposite material

Pigment & Resin Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Purpose This paper aims to control the clay’s dispersion within PA6 matrix. Cloisite Na+, a naturally occurring sodium montmorillonite (NaMMT), and 30B 93A, two organophilic MMT (OMMT), were used for this purpose. Design/methodology/approach By using twin-screw extruder melt mixing, Polyamide 6 (PA6)/NaMMT nanocomposites with 1, 3, 5 10 Wt.% Na+ PA 93A created. PA6/OMMT nanocomposite investigate how organoclay disperses PA6. Findings The link among silicate layer was evaluated via (FTIR), confirming presence of compact contact between nanosilicate segments. Thermal behavior obtained through thermogravimetric analyzer. data confirmed that thermal moderately improved once addition filler, in order: Na+>Cloisit 93A>Cloisit 30B.Electrical properties have been studied measuring dielectric constant, loss conductivity measurment procced at frequencies from –1 107 Hz temperatures 40°C 120°C, constant (έ) sharply increased increasing parameters temperature frequency. Originality/value hybrid nanomaterials PA6/ or can be credited as electronic nanodevices microwave semiconductors materials small amount nanoclay filler illustrated conclusion.

Language: Английский

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Biodegradable Poly(d,l-lactide-co-ε-caprolactone) Electrospun Scaffolds Outperform Antifibrotic-Loaded Meshes in an in Vivo Tissue Regeneration Model

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Wound healing is a complex and dynamic process of replacing missing cellular structures tissue layers. Clinical practice includes the application sterile bandage to promote restrain infection, like commercial nonbiodegradable meshes. However, while inert, nontoxic, nonimmunogenic, they can cause calcification, fibrosis, inflammation, potentially hindering in long term. To address this challenge enhance wound healing, we developed totally biodegradable electrospun poly(d,l-lactide-co-ε-caprolactone) (PDLLCL) drug delivery system that incorporates two already FDA-approved antifibrotics, pirfenidone (PIRF) triamcinolone acetonide (TA). The PDLLCL meshes, fabricated via electrospinning, exhibited homogeneity complete degradation after 120 days, consistent with process. In vitro, functional analysis on RAW 264.7 macrophages revealed no cytotoxicity an immunomodulatory effect PIRF TA compared positive control (lipopolysaccharides, LPS) meshes alone. Lastly, subcutaneous vivo assessment rabbit model, following ISO 10993-6 standard, showed our tailored made were able lower both irritation fibrosis indexes from 2 weeks 4 implantation, highlighting beneficial polymers. saw significant incorporation antifibrotics for indexes. This underscores potential as possible alternative reducing use intermittent antifibrotic agents during

Language: Английский

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