Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Polymers, Journal Year: 2024, Volume and Issue: 16(6), P. 843 - 843

Published: March 19, 2024

Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, off-target effects of chemotherapy known to produce side and dose-limiting toxicities. Novel delivery platforms based on natural synthetic polymers enhanced pharmacokinetic potential treatment cancer have grown tremendously over past 10 years. Polymers can facilitate selective targeting, enhance prolong circulation, improve delivery, provide controlled release cargos through various mechanisms, including physical adsorption, chemical conjugation, internal loading. Notably, that biodegradable, biocompatible, physicochemically stable considered be ideal carriers. This biomimetic bio-inspired system offers a bright future effective drug overcome obstacles encountered. review focuses barriers impact success as well recent developments improving

Language: Английский

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Mechanisms of Targeted Drug Delivery for Liver Cancer: Active, Passive, and Subcellular Strategies

Journal of Biosciences and Medicines, Journal Year: 2025, Volume and Issue: 13(02), P. 369 - 384

Published: Jan. 1, 2025

Language: Английский

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Emerging natural polymer-based architectured nanotherapeutics for the treatment of cancer

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129434 - 129434

Published: Jan. 15, 2024

Language: Английский

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Lenalidomide-utilizing self-assembled immunogenic cell death-inducing heparin/doxorubicin nanocomplex for anticancer immunotherapy

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102677 - 102677

Published: Feb. 21, 2025

Language: Английский

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A nanomedicine composed of polymer-ss-DOX and polymer-Ce6 prodrugs with monoclonal antibody targeting effect for anti-tumor chemo-photodynamic synergetic therapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 272 - 283

Published: March 7, 2024

Language: Английский

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CD147/Basigin Is Involved in the Development of Malignant Tumors and T-Cell-Mediated Immunological Disorders via Regulation of Glycolysis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17344 - 17344

Published: Dec. 11, 2023

CD147/Basigin, a transmembrane glycoprotein belonging to the immunoglobulin superfamily, is multifunctional molecule with various binding partners. CD147 binds monocarboxylate transporters (MCTs) and supports their expression on plasma membranes. MTC-1 MCT-4 export lactic acid that converted from pyruvate in glycolysis maintain intracellular pH level stable metabolic state. Under physiological conditions, cellular energy production induced by mitochondrial oxidative phosphorylation. Glycolysis usually occurs under anaerobic whereas cancer cells depend aerobic conditions. T also require for differentiation, proliferation, activation. Human malignant melanoma expressed higher levels of MCT-1 MCT-4, co-localized membrane, showed an increased rate compared normal human melanocytes. silencing siRNA abrogated membrane disrupted glycolysis, inhibiting cell activity. Furthermore, involved psoriasis. was absent CD4+ CD147-deficient mice. The naïve mice exhibited low capacity differentiate into Th17 cells. Imiquimod-induced skin inflammation significantly milder than wild-type Overall, CD147/Basigin development tumors T-cell-mediated immunological disorders via regulation.

Language: Английский

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Current and Near-Future Technologies to Quantify Nanoparticle Therapeutic Loading Efficiency and Surface Coating Efficiency with Targeted Moieties

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 362 - 362

Published: March 31, 2025

Active targeting nanoparticles are a new generation of drug and gene delivery systems with the potential for greatly improved therapeutics compared to conventional nanomedicine approaches. Despite their potential, translation active faces challenges in production scale-up batch consistency. Accurate quality control methods nanoparticle therapeutic payload coating characterization critical attaining desired levels repeatability, drug/gene loading efficiency, molecule effectiveness, safety profiles. Current limitations technologies, such as relying on ensemble-average analysis, pose assessing content surface modification heterogeneity, which can affect outcomes. Single-molecule analysis technologies have emerged promising alternative, offering rich information heterogeneity stochastic variations between batches. This review first evaluates identifies traditional tools that rely indirect, bulk solution quantification methods. Subsequently, newly emerging introduced targeted moiety efficiencies single-nanoparticle resolution, help guide researchers towards advancing into clinical setting.

Language: Английский

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Polyelectrolytes for Environmental, Agricultural, and Medical Applications

Polymers, Journal Year: 2024, Volume and Issue: 16(10), P. 1434 - 1434

Published: May 18, 2024

In recent decades, polyelectrolytes (PELs) have attracted significant interest owing to a surge in research dedicated the development of new technologies and applications at biological level. Polyelectrolytes are macromolecules which substantial portion constituent units contains ionizable or ionic groups. These demonstrate varied behaviors across different pH ranges, strengths, concentrations, making them fascinating subjects within scientific community. The aim this review is present comprehensive survey progress application studies their derivatives various fields that vital for advancement, conservation, technological planet, including agriculture, environmental science, medicine. Through bibliographic review, we seek highlight significance these materials extensive range modern times.

Language: Английский

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Acetalated Dextran (Ac-DEX) in Targeted Drug Delivery and Cancer Immunotherapy: A Multipurpose Biodegradable Polymer

Journal of Macromolecular Science Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: April 7, 2025

Language: Английский

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Analytical Techniques for Characterizing Tumor-Targeted Antibody-Functionalized Nanoparticles

Life, Journal Year: 2024, Volume and Issue: 14(4), P. 489 - 489

Published: April 10, 2024

The specific interaction between cell surface receptors and corresponding antibodies has driven opportunities for developing targeted cancer therapies using nanoparticle systems. It is challenging to design develop such nanomedicines antibody ligands, as the final nanoconjugate's specificity hinges on cohesive functioning of its components. multicomponent nature antibody-conjugated nanoparticles also complicates characterization process. Regardless type nanoparticle, it essential perform physicochemical establish a solid foundation knowledge suitable preclinical studies. A meaningful evaluation should include determining quantity orientation antibodies, confirming antibodies' integrity following attachment, assessing immunoreactivity obtained nanoconjugates. In this review, authors describe various techniques (electrophoresis, spectroscopy, colorimetric assays, immunoassays, etc.) used analyze properties functionalized with discuss main results.

Language: Английский

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