Advances in Lipid Nanoparticle‐Based Disease Treatment

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Lipid nanoparticles (LNPs) have emerged as a transformative platform for the targeted delivery of therapeutic agents, revolutionizing treatment paradigms across spectrum diseases. Since inception liposomes in 1960s, lipid‐based nanotechnology has evolved to address limitations such poor bioavailability, off‐target effects, and instability, thereby enhancing efficacy safety drug administration. This review highlights latest advancements LNPs technology, focusing on their application cancer therapy, gene infectious disease management, glaucoma, other clinical areas. Recent studies underscore potential deliver messenger RNA (mRNA) small interfering (siRNA) precise genetic intervention, exemplified by breakthroughs interference CRISPR‐Cas9 genome editing. Additionally, been successfully employed ameliorate conditions, demonstrating versatility addressing both acute chronic disorders. However, challenges persist concerning large‐scale manufacturing, long‐term stability, comprehensive evaluations. Future research must focus optimizing formulations, exploring synergistic combinations with existing therapies, expanding scope treatable The integration into personalized medicine exploration applications diseases represent promising avenues further investigation. are poised play an increasingly central role development next‐generation therapeutics.

Language: Английский

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Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 290 - 290

Published: Feb. 20, 2025

Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1), polydispersibility index (Y2), zeta potential (Y3), encapsulation efficiency (Y4). The optimized formula selected utilizing Design Expert® software version 13, which additionally enhanced by preparing TTO-loaded HESP-NLCs. In vitro release, Raman spectroscopy, transmission electron microscopy were carried out both nanoparticles. Cytotoxicity, in vivo wound-healing assessments, skin irritancy tests performed performance TTO-incorporated HESP-NLCs compared HESP-SLNs. Results: demonstrated PS (280 ± 1.35 nm), ZP (−39.4 0.92 mV), PDI (0.239 0.012), EE% (88.2 2.09%). NLCs Q6% (95.14%) vs. (79.69%), SLNs showed superior antimicrobial Both exhibited spherical morphology compatibility between HESP excipients. highest closure percentage, supported histological analysis inflammatory biomarker outcomes. Cytotoxicity evaluation 87% cell viability untreated HSF cells, test confirmed safety NLCs. Conclusions: are promising candidates exhibiting capabilities, making them a therapeutic option cutaneous management.

Language: Английский

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Recent advances in lipid-based nanocarriers for advanced skin cancer therapy

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125203 - 125203

Published: Jan. 1, 2025

Language: Английский

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Encapsulation of synthesized purpurin-18-N-aminoimide methyl ester in lipid nanovesicles for use as agents in photodynamic cancer therapy

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Multifaceted Applications of Solid Lipid: A Comprehensive Review

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2), P. 834 - 860

Published: Feb. 5, 2024

Lipids originate from plant and animal sources have significant roles in various fields, like pharmaceuticals, cosmetics, food, paint, leather, agriculture, microfluidics, oil industries. Over the years, with development of technology, different types lipids been synthesized or extracted used based on their industrial need. are heterogeneous group compounds related to fatty acids insoluble water but soluble organic solvents. One category great importance is solid lipids. Solid a type that remain at ambient temperature. In past, were obtained natural they mainly as bulking agents bases for dosage forms. due course time, after industrialization, evolved gained more significance. drug targeting controlled delivery release rate modifiers, solubilizers, stabilizers, permeation enhancers improved biopharmaceutical performance drugs. These also popular diversified applications industries mentioned above. this review, authors selected some Stearic acid, Compritol®ATO 888, Precirol®ATO 5, Glyceryl Monostearate, Witepsol®, Carnauba wax, Softisan®, Cholesterol, Dynasan®, Cetyl palmitate discussed about properties applications.

Language: Английский

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Novel paradigm of therapeutic intervention for skin cancer: challenges and opportunities

Future Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 1, 2024

Abstract Background Skin cancer continues to be an imperative global health issue, urging continuous exploration of treatment methodologies. Conventional treatments for skin include surgical interventions, immunotherapy, targeted therapy, chemotherapy, and radiation therapy. However, these methods often present obstacles like resistance, systemic toxicity, limited effectiveness in advanced stages, infection risk, pain, long recovery, impact on healthy tissue. Main body the abstract Nanomedicine holds promise by facilitating precise drug administration, early detection, heightened therapeutic efficiency via localized delivery systems. The integration nanomedicine into alleviation therapies demonstrates optimistic outcomes, including refined delivery, augmented bioavailability, minimized adverse effects, potential theranostic applications. Recent breakthroughs have propelled advancements treatment, showing significant transforming paradigm. presents review provides comprehensive aspects existing their challenges, spotlighting recent nanomedicine. Short conclusion This delineates landscape treatments, underscores constraints, highlights strides that transform paradigm ultimately elevating patient prognosis. Importantly, emphasizes substantial challenges hinder clinical translation nanomedicines suggests possible remedies surpass them. Graphic

Language: Английский

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A Ligand-Free Approach towards Coumarin Analogs via Natural Deep Eutectic Solvent-Mediated Suzuki–Miyaura Coupling

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4398 - 4398

Published: Sept. 16, 2024

A ligand-free approach for the Suzuki-Miyaura cross coupling reaction using Natural Deep Eutectic Solvents (NaDES) towards coumarin analogs is described. model between synthetically prepared 3-(4-acetyloxy-phenyl)-6-bromo-4-methyl-coumarin (3b) and phenylboronic acid was performed in five different NaDES as well pure glycerol, two inorganic bases palladium catalysts. The proceeded smoothly Choline Chloride/Glycerol (ChCl/Gly) Betaine/Glycerol (Bet/Gly) at 90 °C 24 h, affording desired product high yields up to 95%. combination of K2CO3, Pd(OAc)2 ChCl/Gly provided optimum purity compounds, while solvent successfully recycled reused times. developed methodology applicable boronic acids bearing various substituents. formation nanoparticles mixture observed, size associated with yield. In addition, all glycerol-based NaDES, an effective removal acetyl group acetyloxy–coumarin observed; thus, it noteworthy that Suzuki–Miyaura deacetylation were achieved one pot. ten novel derivatives synthesized structurally characterized 1D 2D NMR spectroscopy tested their cytotoxicity against A431 squamous cancer cell line, presenting significant activity.

Language: Английский

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Preparation and Antibacterial Activity Evaluation of Daphnetin-Loaded Poloxamers/Polyvinylpyrrolidone Thermosensitive Hydrogels

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Antibiotic misuse and bacterial resistance are pressing issues threatening public health. Natural plant extracts with bactericidal properties offer potential alternatives to reduce or replace antibiotic use. This study aims develop a thermosensitive hydrogel containing daphnetin (DAP-TG) using poloxamers 407 (P407), polyvinylpyrrolidone (PVP), 188 (P188). We systematically evaluated the gel's antibacterial activity against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus), as well its mechanisms. By examining gelation temperature time, degradation in vitro release performance of DAP-TG, we produced sustained-release DAP-TG rapid phase transition at (31.6 ± 0.1) °C. Its structure was characterized through Fourier transform infrared (FTIR) spectroscopy scanning electron microscopy (SEM). The results indicated that DAP formed presented 3D network spatial structure. biocompatibility explored hemolysis test cytotoxicity test. possessed excellent biocompatibility. efficacy E. S. assessed minimum inhibitory concentration (MIC), (MBC), growth curve, inhibition zone tests. Results showed exhibited both aureus, MIC values 1.28 0.32 mg/mL. mechanism preliminarily investigation cell content leakage, AKP membrane permeability, SEM, ROS production, biofilm activity. induced irreversible damage membranes resulting enhanced elevated levels, inhibited formation. Our indicates exhibits effective vitro, making it promising candidate for applications food pharmaceutical products.

Language: Английский

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