Fundamental Research,
Journal Year:
2024,
Volume and Issue:
5(2), P. 782 - 795
Published: Feb. 29, 2024
Highly
comminuted
fractures
and
bone
defects
pose
a
significant
challenge
for
orthopedic
surgery.
Current
surgical
procedures
commonly
rely
on
metal
implants
(such
as
plates,
nails
pins)
fracture
internal
external
fixations,
but
they
are
likely
to
result
in
problems,
such
stress
shielding
poor
healing.
Bone
adhesive
represents
an
attractive
alternative
the
treatment
of
fracture.
The
ideal
should
satisfy
several
performance
requirements,
including
high
adhesion
strength
tissues,
rapid
in-situ
curing
physiological
environment,
good
biocompatibility
with
no
toxicity,
degradability,
stability
vivo.
Among
these
degradability
is
crucial
characteristic
adhesives.
This
property
enables
material
be
easily
removed
without
need
surgery
at
later
stage,
ensuring
regeneration
tissue
any
hindrance.
degradation
rate
varies
depending
application
scenarios
ranging
from
weeks
years.
Many
adhesives
unable
guarantee
while
achieving
other
necessary
performances.
Therefore,
this
article
provides
detailed
overview
strategies
fabricate
biodegradable
polymer
that
can
maintain
bulk
strength,
properties.
Finally,
current
challenges
clinical
translation
their
future
development
directions
discussed.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2534 - 2534
Published: Nov. 6, 2024
:
Inflammation
is
caused
by
an
excess
of
Sodium
ions
inside
the
cell.
This
generates
a
variation
in
cell's
membrane
electric
potential,
becoming
steady
state
from
thermodynamic
viewpoint.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(11), P. e21566 - e21566
Published: Nov. 1, 2023
The
design
of
functional
micro
or
nanostructured
surfaces
is
undergoing
extensive
research
for
their
intriguing
multifunctional
properties
and
large
variety
potential
applications
in
biomedical
field
(tissue
engineering
cell
adhesion),
electronics,
optics
microfluidics.
Such
nanosized
topographies
can
be
easily
fabricated
by
various
lithography
techniques
also
further
reinforced
synergic
effect
combining
aforementioned
structures
along
materials
with
already
outstanding
antibacterial
properties.
In
this
work
we
novel
micro/nanostructured
substrates
using
soft
replication
method
subsequent
thermal
nanoimprint
method,
creating
films
based
on
poly
(l-lactic
acid)
(PLLA)
fortified
thin
silver
deposited
PVD.
Main
nanoscale
patterns
were
replicating
surface
optical
discs
(CDs
DVDs),
which
proved
to
easy,
fast
inexpensive
relatively
area
patterned
surfaces.
Their
antimicrobial
activity
was
examined
vitro
against
the
bacteria
Escherichia
coli
Staphylococcus
epidermidis
strains.
results
demonstrated
that
nanopatterned
actually
improved
conditions
bacterial
growth
compared
pristine
PLLA
films,
novelty
formation
Ag
nanoparticles
surface/and
bulk,
while
nanoparticle
enhanced
exhibited
excellent
both
strains,
circa
80
%
efficacy
4
h
complete
bactericidal
span
24
h.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(10), P. 293 - 293
Published: Oct. 1, 2024
Implant
stability
can
be
compromised
by
factors
such
as
inadequate
bone
quality
and
infection,
leading
to
potential
implant
failure.
Ensuring
longevity
is
crucial
for
patient
satisfaction
of
life.
In
this
multicenter,
randomized,
double-blind
clinical
trial,
we
assessed
the
impact
a
bioactive
liquid
(BBL)
on
Galaxy
TS
implant’s
performance,
stability,
osseointegration.
We
evaluated
osseointegration,
pain
levels
using
initial
quotient
(ISQ)
measurements,
CBCT
scans,
assessment
post-surgery.
Surface
analysis
was
performed
scanning
electron
microscopy
(SEM)
atomic
force
(AFM).
vitro
studies
examined
BBL’s
effects
dental
pulp
pluripotent
stem
cells’
(DPPSCs’)
osteogenesis
inflammation
modulation
in
human
macrophages.
All
implants
successfully
osseointegrated,
demonstrated
results
our
histological
studies.
The
BBL-treated
showed
significantly
lower
scores
day
7
(p
<
0.00001)
improved
30
(ISQ
>
62.00
±
0.59,
p
8
×
10−7).
By
60,
scans
revealed
an
increased
area
ratio
implants.
AFM
images
softening
wettability
effect
surfaces.
Furthermore,
BBL
promoted
DPPSCs’
modulated
inflammatory
markers
primary
This
study
presents
compelling
biological
evidence
that
treatment
improves
reduces
pain,
enhances
formation,
possibly
through
surface
tension
immunomodulatory
effects.
advancement
holds
promise
enhancing
outcomes
longevity.
