Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)

Oncology Reports, Journal Year: 2024, Volume and Issue: 52(6)

Published: Oct. 14, 2024

Bone metastasis (BM) is a common complication of cancer and contributes to higher mortality rate in patients with cancer. The treatment BM remains significant challenge for oncologists worldwide. colony‑stimulating factor (CSF) has an important effect on the multiple cancers. In vitro studies have shown that CSF acts as cytokine, promoting colony formation hematopoietic cells by activating granulocytes macrophages. Other not only promotes aggressiveness but also correlates development prognosis various types In recent years, been primarily investigated using cellular animal models, limited clinical available. present review discussed composition function CSF, well its role progression across mechanisms which osteoclast‑ osteoblast‑mediated occur are comprehensively described. addition, action emerging therapeutic agents explored their potential applications. However, further required validate these findings.

Language: Английский

Extraction, properties, and modification of chitosan-based nanoparticles

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Nov. 8, 2024

Language: Английский