Enhancement of osteogenic and antibacterial properties of 3D-printed porous Ti-6Al-4V implants using multi-scale composite structures and ZnO nanoparticles

Journal of Alloys and Compounds, Journal Year: 2025, Volume and Issue: unknown, P. 179620 - 179620

Published: March 1, 2025

Language: Английский

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Development and characterization of SA/PEG hydrogel membranes with Ag/ZnO nanoparticles for enhanced wound dressing

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 317, P. 129170 - 129170

Published: March 13, 2024

Language: Английский

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Optimizing hydrogel performance composed of Japanese pagoda tree extract loaded-gelatin-sodium alginate-polyethylene oxide for biomedical applications: Influence incorporated calcium-based metal organic frameworks and zinc oxide NPs

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143526 - 143526

Published: April 1, 2025

Language: Английский

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Dual-functional composite hydrogel platform: A “kill two birds with one stone” strategy for anti-infection and osseointegration in the treatment of infectious bone defects

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155337 - 155337

Published: Sept. 1, 2024

Infectious bone defect (IBD), caused by various factors, frequently recur and are challenging to cure. Current treatments predominantly rely on a combination of antibiotics traditional surgery, yet they have not significantly reduced long-term recurrence rates. Given the complex microenvironment persistent mechanisms mediated bacteria, it is crucial for implants enhance osseointegration while ensuring sustained effective infection control. Hydrogels emerged as promising solution in tissue engineering due their excellent drug-loading efficiency, controlled drug release, adjustable mechanical strength, biocompatibility. Over past decade, hydrogels with dual anti-infection pro-osseointegration functions demonstrated efficacy treating IBD, making clinical application possible. This review summarizes current highlighting pros cons infection-mediated immune microenvironments. Additionally, discusses essential physicochemical properties suitable IBD reviews latest advancements dual-functional hydrogels. Finally, addresses future prospects, technical challenges, unresolved issues development Overall, this aims facilitate advancement implementation tailored therapeutic needs IBD.

Language: Английский

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Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 11, 2024

Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss. Emerging evidence indicates that ferroptosis plays role in OA development. However, most research has concentrated on regulation involving typical iron ions, potentially neglecting significance elevated copper ions both serum fluid patients with OA. This review aims fill this gap systematically examining interplay between metabolism, oxidative stress, ferroptosis, copper-associated death It will provide comprehensive overview ions' regulating their dual approach seeks offer new insights for further research, prevention, treatment

Language: Английский

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Advances of Metal‐Based Nanomaterials in the Prevention and Treatment of Oral Infections

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

The complicated environment of the oral cavity presents significant challenges to traditional antibacterial approaches, which has driven exploration novel therapeutic strategies. Metal-based nanomaterials (MNMs), with diverse mechanisms (e.g., membrane disruption, oxidative stress) and evolution from empirical theory-guided design, exhibit immense potential. This review introduces pioneering Hierarchical Response Strategy Framework, systematically classifying MNM systems into three progressive levels: Primary category, comprising MNMs that exert spontaneous effects based on inherent physicochemical properties ion release); Secondary including precisely controlled actions by microenvironmental or stimulus-responsive light-induced ROS); Tertiary encompassing integrate regenerative functions for multidimensional therapy remineralization). Through this framework, authors elucidate MNMs' transition single-function precision-controlled, multifunctional synergy, analyze impact metal elements structural design efficacy, summarize their applications in dental caries, endodontic infections, periodontal disease, etc. framework offers a perspective existing research theoretical foundation rational next-generation precise, smart, comprehensive anti-infective materials.

Language: Английский

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Engineered nerve guide conduit enhances peripheral nerve regeneration by modulating the microenvironment through macrophage-triggered cascade reactions

Bioactive Materials, Journal Year: 2025, Volume and Issue: 51, P. 46 - 69

Published: May 7, 2025

Language: Английский

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Synergistic Optimization Strategies for SA-PVA Hydrogel Nanofiltration Membrane Performance by MWCNTs and TiO2

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

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Evaluating Polyelectrolyte Multilayers with Incorporated Silver or Copper Oxide Nanoparticles for Biomedical Applications

Published: Jan. 1, 2024

The growing concern about nosocomial infections caused by antibiotic‐resistant bacteria that can develop after implantation of medical devices motivates the search for antibiotic treatments alternatives. In this sense, development antibacterial coatings locally inhibit microbial adhesion is particular interest. Among various coatings, polyelectrolyte multilayers (PEMs) containing antimicrobial components are attracting special attention as they be applied to different types surfaces. On other hand, metal/metal oxide nanoparticles stand out agents with low potential promote resistance. So far, PEMs silver or copper have been investigated, but no attempt has made compare properties these two nanoparticles.In paper, build-up poly-L-lysine and poly-L-glutamic acid embedded (PEMAg) (PEMCuO) was investigated their physico-chemical biological were compared. Nanoparticles successfully an anionic component within PEM, confirmed quartz-crystal microbalance measurements. Energy dispersive spectroscopy revealed distribution over coated surface. release Ag Cu sustained, 10 % 2 released 24 hours. All exhibited MG-63 cell viability above 70 %, confirming biocompatibility. PEMCuO showed better biofilm prevention compared PEMAg, entirely preventing Pseudomonas aeruginosa enabling only a weak formation Staphylococcus aureus biofilm.The results obtained confirm high devices, also

Language: Английский

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Poly(Amino Acid) LbL Multilayers With Embedded Silver and Copper Oxide Nanoparticles as Biocompatible Antibacterial Coatings

Advanced Materials Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract The growing concern over implant‐associated infections motivates the development of novel antibacterial coatings for medical devices as an effective strategy in reducing occurrence IAI. Polyelectrolyte multilayers (PEMs) incorporating metal/metal oxide nanoparticles (NPs) antimicrobial components receive special attention their ability to coat diverse surface types and low potential induce resistance. This study investigates poly(amino acid) consisting poly‐L‐lysine poly‐L‐glutamic acid with embedded silver (PEMAg) or copper (PEMCuO) deposited on titanium surfaces coating surfaces. results quartz crystal microbalance dissipation, scanning electron microscopy, dispersive spectroscopy show that both NPs are successfully incorporated PEM entire coated surface. incorporation prevents burst release. viability MG‐63 cells is higher than 70% all investigated PEMs, confirming biocompatibility. PEMCuO shows better biofilm prevention compared PEMAg, entirely preventing Pseudomonas aeruginosa allowing formation only weak Staphylococcus aureus biofilm. obtained confirm high acids) biocompatible devices.

Language: Английский

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