Visible Light-Responsive Composition-Dependent Morphology and Cargo Release in Mixed Micelles of Dendron Amphiphiles
Shankarrao V. Avhad,
No information about this author
Sugam Kumar,
No information about this author
Ashootosh V. Ambade
No information about this author
et al.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
2,2-Bis-(methylol)propionic
acid-based
second-generation
polyester
dendron
amphiphile
(T-D)
containing
visible
light-responsive
donor-acceptor
Stenhouse
adduct
(DASA)
as
hydrophobic
tails
is
synthesized.
Micelles
of
T-D
and
its
mixed
micelles
varying
compositions
with
nonresponsive
lauryl
groups
are
prepared
in
aqueous
solution.
In
transmission
electron
microscopy
atomic
force
analyses,
amphiphiles
show
rice
grain-like
ellipsoidal
the
predominant
morphology.
Mixed
display
a
composition-dependent
morphology
gradient
such
that
changes
from
grain
like
to
completely
spherical
decreasing
content
amphiphile.
Complete
change
partial
reversal
micelles,
finally
leading
ill-defined
aggregates,
observed
when
subjected
light-dark
storage
photoswitching
cycles.
Small-angle
neutron
scattering
(SANS)
analysis
1
wt.%
micellar
solution
THF:water
(10:90)
reveals
only
minor
shape
size
upon
photoirradiation,
data
could
be
fitted
or
model.
Release
dye
tuned
by
photoresponsive
Cellular
uptake
light-triggered
release
drug
demonstrated
using
MDA-MB-231
cells,
suggesting
their
applicability
for
delivery.
Language: Английский
Periodic mesoporous organosilica with Serine-Tryptophan dipeptide framework by encapsulating curcumin to enhance ultraviolet shielding
Hengchang He,
No information about this author
Huapei Peng,
No information about this author
Fang-Yuan Liu
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 21, 2025
Abstract
Plant
compound
curcumin
with
strong
absorption
capabilities
in
UV
range
has
gained
significant
attention
for
its
potential
application
as
a
natural
ultraviolet
shielding
agent.
However,
certain
challenges
such
limited
water
solubility
and
photostability
sill
restrict
usage.
Nanoencapsulation
one
of
the
advanced
delivery
systems
is
explored
to
overcome
these
limitations.
In
this
study,
we
design
periodic
mesoporous
organosilica
(PMO)
material
Serine-Tryptophan
dipeptide
framework
via
sol-gel
synthesis
method
encapsulate
sunscreen.
The
PMO
were
prepared
by
co-condensation
self-designed
bilateral
organic
silane
precursor
tetraethyl
orthosilicate
presence
template
CTAB
under
alkali
condition.
before
after
encapsulating
characterized
XRD,
FTIR
nitrogen
adsorption-desorption
analysis,
which
confirmed
maintenance
structure
within
encapsulation
system.
Adsorption
kinetics
isotherms
during
well
described
pseudo-second-order
model
Freundlich
isotherm,
respectively,
indicating
chemisorption-dominated
multimolecular
layer
adsorption
process.
Besides,
exhibited
comprehensive
broad-spectrum
photoprotection
against
light
dominant
protection
UVA
region.
After
curcumin,
sun
factor
(SPF)
was
significantly
enhanced,
demonstrating
excellent
photo-protective
nature
material.
critical
wavelength
(λc)
exceeded
370
nm.
simulated
sweat
release
experiment
evaluate
photostability,
only
2.6%
released
24
hours,
exceptional
stability.
Consequently,
our
findings
suggest
that
can
serve
building
constituents
development
novel
Furthermore,
could
provide
stable
protection,
effective
filter.
Language: Английский
Cancer cell membrane-modified Soluplus® micelles for gemcitabine delivery to pancreatic cancer using a prodrug approach
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
662, P. 124529 - 124529
Published: July 30, 2024
Pancreatic
cancer
(PC)
is
one
of
the
most
lethal
malignancies
worldwide
and
its
incidence
increasing.
Chemotherapy
often
associated
to
limited
efficacy,
poor
targeting
systemic
toxicity.
In
this
work,
hydrophilic
gemcitabine
(GEM),
widely
used
in
PC
treatment
alone
or
combination,
was
conjugated
with
vitamin
E
succinate
(VES)
encapsulated
Soluplus®
micelles.
This
prodrug
approach
facilitated
encapsulation
anticancer
drug
into
self-assembled
copolymer
Soluplus®/VES-GEM
micelles
were
optimized
regarding
ratio
components
preparation
process.
The
small-sized
(<80
nm),
monodisperse,
highly
stable,
efficiently
retaining
conjugate
showing
significant
antiproliferative
activity
against
BxPC3
cell
line.
To
improve
biofunctionalization
properties
prepared
micelles,
biomimetic
modification
membrane
further
attempted
by
co-extruding
(BxPC3)
nanovesicles
Several
protocols
prepare
BxPC3-modified
outcomes
analyzed
detail.
Overall,
results
pave
way
innovative
PC-targeted
nanotherapies
maximizing
GEM
hydrophobic
compartments
high
stability
affinity.
also
highlight
need
higher
resolution
techniques
characterize
coating
nanocarriers
bearing
shells.
Language: Английский
Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents
Macromolecular Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 23, 2024
Abstract
Pluronic
F127
copolymer
is
used
as
the
main
component
to
design
injectable
gels
for
therapeutic
applications.
Xanthan
gum
added
an
excipient
improve
gel
properties
under
physiological
conditions.
A
polyphenol
bioactive
compound,
curcumin,
selected
agent
with
beneficial
effects
on
metabolism
and
many
diseases.
The
encapsulation
efficiency
stability
of
formulations
are
investigated
in
aqueous
environment
acetic
acid
solutions.
interactions
between
hydrophobic
polymer
matrix
through
rheology,
DLS,
FTIR
spectroscopy.
viscoelasticity
gels,
correlated
network
structure,
influenced
by
xanthan
or
addition.
analysis
curcumin
incorporated
into
provides
evidence
interaction
phenyl
rings
both
keto‐enol
di‐keto
tautomers
polymeric
matrix.
spherical
curcumin‐encapsulated
micelles
provided
antioxidant
properties.
kinetics
release
from
F127‐based
suggests
anomalous
transport
phenomena
controlled
diffusion
hydrodynamic
effects.
Both
lyophilized
form
micellar
encapsulated
composites
exhibited
good
long‐term
storage
ambient
Language: Английский
Harmonizing Nature and Technology: Lipidic Nano-phytotherapeutics in the Management of Atopic Dermatitis
Revista Brasileira de Farmacognosia,
Journal Year:
2024,
Volume and Issue:
34(5), P. 948 - 968
Published: July 20, 2024
Language: Английский
A novel quercetin-phospholipid complex gel for enhanced skin permeability and photoprotection - Ex vivo and in vivo studies
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 106574 - 106574
Published: Dec. 1, 2024
Language: Английский
Exploring the Antiaging Properties of Curcumin, Flaxseed, and Collagen: A Comprehensive Review
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(48)
Published: Dec. 1, 2024
Abstract
Aging
is
a
progressive
and
irreversible
pathophysiological
process.
It
manifests
as
reduction
in
the
functioning
of
tissues
cells
well
marked
increase
risk
several
aging‐related
diseases,
including
metabolic,
immune
system
cardiovascular
disorders.
Therefore,
search
for
potent
antiaging
agents
crucial.
Curcumin,
collagen,
flaxseed
are
considered
due
to
their
unique
properties
mechanisms
that
help
combat
signs
aging.
phytochemical
exhibits
strong
antioxidant
anti‐inflammatory
properties,
Collagen,
an
essential
protein
skin
elasticity
strength,
rich
lignans,
antioxidants,
omega‐3
fatty
acids
offers
nutrient‐dense
profile
helps
shield
from
oxidative
stress
inflammation.
This
review
focuses
on
curcumin,
flaxseed,
highlighting
structures
molecular
cellular
Various
extrinsic
intrinsic
factors
lead
decreases
production
hyaluronic
acid,
elastin
making
prone
wrinkles,
damage.
These
impacts
discussed
this
article.
By
examining
current
research,
sheds
light
potential
benefits
innovative
uses
these
substances
treatments.
The
article
also
identifies
future
directions
research
development
promising
field.
Language: Английский