Enhancing wear resistance, anti-corrosion property and surface bioactivity of a beta-titanium alloy by adopting surface mechanical attrition treatment followed by phosphorus ion implantation

Applied Surface Science, Journal Year: 2024, Volume and Issue: 671, P. 160766 - 160766

Published: July 16, 2024

Language: Английский

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Copper Complexes with New Glycyl-l-histidyl-l-lysine–Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

In recent years, hyaluronic acid (HA) and the natural tripeptide glycyl-l-histidyl-l-lysine (GHK), especially its copper(II) complex (GHK-Cu), individually have been shown to exert helpful properties for bone protection regeneration. However, they are not strong enough handle oxidative stress, hydrolytic attack, or environmental conditions. Being aware that conjugation chemistry has recently emerged as an appealing approach generating new molecular entities capable of preserving integrity their moieties delaying degradation, herein we present synthesis conjugates HA with GHK (GHK-HA), at different loadings tripeptide. GHK-HA binds ions potentiates chemical biological two components in vitro assays. The results highlight copper's role promoting expression release certain trophic, angiogenic, osteogenic factors, including brain-derived neurotrophic factor (BDNF), vascular endothelial growth (VEGF), well morphogenetic protein-2 (BMP-2). protective regenerative activities metal ion related translocation intracellular chaperones Copper Chaperone Superoxide Dismutase (CCS) Antioxidant-1 (Atox1) nucleus where act transcription factors.

Language: Английский

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Functional Nanoparticle Developments for 3D-Printed Biodegradable Implants- A Comprehensive Review

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: 19, P. 100541 - 100541

Published: May 1, 2025

Language: Английский

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Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 11, 2024

Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss. Emerging evidence indicates that ferroptosis plays role in OA development. However, most research has concentrated on regulation involving typical iron ions, potentially neglecting significance elevated copper ions both serum fluid patients with OA. This review aims fill this gap systematically examining interplay between metabolism, oxidative stress, ferroptosis, copper-associated death It will provide comprehensive overview ions' regulating their dual approach seeks offer new insights for further research, prevention, treatment

Language: Английский

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Gelatin/chitosan coating-embedded ZIF-8@DFO on Zn-EGCG: An effective strategy for treating infected bone defects

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 313, P. 144167 - 144167

Published: May 14, 2025

Language: Английский

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