Exploring HSA binding of Irinotecan-Functionalised silver Nanoparticles: Insights from spectroscopic and calorimetric approaches DOI
Aparna Raj,

L. Vidya,

V M Aparna

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126796 - 126796

Published: Dec. 1, 2024

Language: Английский

Structural and anti-ovarian cancer insights into the immunoglobulin G-glabridin nanocomplex DOI
Zhiqiang Guo, Mingyao Tian, Min Zhou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140038 - 140038

Published: Jan. 1, 2025

Language: Английский

Citations

0
Protein-functionalized and intrinsically radiolabeled [188Re]ReOx nanoparticles: advancing cancer therapy through concurrent radio-photothermal effects DOI Creative Commons
Sanchita Ghosh, Apurav Guleria,

Sourav Patra

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Enhancing therapeutic effectiveness is crucial for translating anticancer nanomedicines from laboratory to clinical settings. In this study, we have developed radioactive rhenium oxide nanoparticles encapsulated in human serum albumin ([188Re]ReOx-HSA NPs) concurrent radiotherapy (RT) and photothermal therapy (PTT), aiming optimize treatment outcomes. [188Re]ReOx-HSA NPs were synthesized by a controlled reduction of 188ReO4− HSA medium extensively characterized. The effect was demonstrated vitro murine melanoma (B16F10) cell line. vivo SPECT/CT imaging, autoradiography biodistribution studies performed after intratumoral injection tumor-bearing C57BL/6 mice. potential combined RT PTT also the aforesaid mice model. (size 4–6 nm) with high colloidal radiochemical stability. Upon laser (808 exposure on B16F10 cells incubated NPs, only < 20% alive demonstrating efficacy under Uniform dose distribution retention radiolabeled tumor volume observed via imaging studies. Tumor growth model significantly arrested ~ 1.85 MBq simultaneous irradiation, synergistic benefit PTT. These results demonstrate that intrinsically having unique features such as effects favorable nuclear decay characteristics RT/PTT, hold great promise translation.

Language: Английский

Citations

0
Impacts of neonicotinoid compounds on the structure and function of Apis mellifera OBP14: Insights from SPR, ITC, multispectroscopy, and molecular modeling DOI

Xiangshuai Li,

Shiyu Li,

Fangkui Zhao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114551 - 114551

Published: Feb. 3, 2025

Language: Английский

Citations

0
Impact of trypsin on interfacial conformational evolution of soy protein isolate/soy hull polysaccharide emulsion DOI

Xiulin Liu,

Shengnan Wang, Shanshan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142507 - 142507

Published: March 1, 2025

Language: Английский

Citations

0
Therapeutic Applications of Proliposomes in Pulmonary Drug Delivery DOI

Abdelbary Elhissi,

Dana Elkhalifa, Iftikhar Khan

et al.

Synthesis lectures on biomedical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 113 - 139

Published: Jan. 1, 2025

Language: Английский

Citations

0
Endocrine Disruption of Triphenyl Phosphate via VIT-2 in Caenorhabditis elegans: A Comparative Analysis with Estradiol and 4-Hydroxytamoxifen DOI

Chongli Shi,

Mengyan Huang, Yang Zheng

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138546 - 138546

Published: May 9, 2025

Language: Английский

Citations

0
Plasma protein affinity, antioxidant, and anti-lung cancer properties of O-methylated flavonol rhamnazin DOI Creative Commons

Zheng Chen,

Yan Qiao,

Yu Chen

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(9), P. 105891 - 105891

Published: July 2, 2024

Medicinal herbs can be used for the development of antioxidant and anticancer platforms. However, mechanisms by which bioactive materials show these properties remain largely unclear. Also, a detailed understanding interaction between small compounds carrier proteins like albumin provide useful information about regulation their stability circulation time properties. In this paper, rhamnazin (C17H14O7), an O-methylated flavonol exists in Rhamnus petiolaris, with human serum (HSA) was investigated. anti-lung cancer effects were assessed. The results showed that static rhamnazin-HSA complex formed contribution hydrophobic forces, led to increase content α-helix structure HSA. Cellular assays revealed (10 µM) recovered cell viability proximal renal tubular epithelial cells (HK2) reduced H2O2 (0.5 mM) through reduction ROS, restoration CAT SOD activities GSH content, Bax, Bcl-2, caspase-3. Moreover, data demonstrated induced apoptosis on lung adenocarcinoma A549 associated p53-dependent manner via overexpression apoptotic Bax caspase-3 down-regulation anti-apoptotic Bcl-2. To summarize, potential binding HSA, as well its antioxidant/anticancer properties, are critical solubility compound plasma, therapeutic implications.

Language: Английский

Citations

0
Endocrine Disruption of Triphenyl Phosphate Via Vitellogenin-2 in Caenorhabditis Elegans: A Comparative Analysis with Estradiol and 4-Hydroxytamoxifen DOI

Chongli Shi,

Chongli Shi,

Mengyan Huang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Exploring HSA binding of Irinotecan-Functionalised silver Nanoparticles: Insights from spectroscopic and calorimetric approaches DOI
Aparna Raj,

L. Vidya,

V M Aparna

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126796 - 126796

Published: Dec. 1, 2024

Language: Английский

Citations

0