Synthesis and Characterization of a Novel Modified Biosensor Carbon/Chitosan L-Leucine and Albumin Electrode for Bili-rubin and Uric Acid Blood Detection DOI Creative Commons
Redouan El Khamlichi,

Khalid Riffi Temsamani,

Mohammed Lamarti Sefian

et al.

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(9), P. 097509 - 097509

Published: Sept. 2, 2024

Bilirubin (BR) is a yellow-to-orange bile pigment produced by hemoglobin breakdown. It circulates in the blood, absorbed liver, and then conjugated to form bilirubin diglucuronide. Its increased level serum (Hyperbilirubinemia) may considered as an indication of certain diseases such neonatal jaundice, hepatitis, severe liver failure with cirrhosis. Thus, monitoring BR plasma clinically important. Herein, novel carbon/chitosan paste electrode modified L-leucine Albumin (C/Chi-PL-BSA) synthesized tested for electrochemical sensitive determination Uric Acid. Significate sensitivity important selectivity linear range 1.00–150.00 μM BR, 10.00–600.00 UA were obtained. Moreover, micromolar detection limits 0.40 1.00 achieved at pH13. The proposed oxidation mechanisms alkaline media have been supported DFT calculations B3LYP/ 6–31 G(d) theory. easy preparation high reproducibility made this very appropriate pharmaceutical preparations BR. Furthermore, Analyses using human performed, demonstrating percentage recovery.

Language: Английский

Fabrication of Highly Fluorescent Nitrogen and Phosphorus Dual‐Doped Carbon Dots for Selective Sensing of Rutin DOI
Reham E. Kannouma, Amira H. Kamal, Mohamed A. Hammad

et al.

Luminescence, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 1, 2025

ABSTRACT Based on nitrogen and phosphorus co‐doped carbon dots (NP‐CDs), a direct, quick, selective sensing probe for fluorometric detection of rutin has been developed. Utilizing ethylene diamine tetra acetic acid (EDTA) as source diammonium hydrogen phosphate (NH 4 ) 2 HPO source. The NP‐CDs were synthesized in less than 3 min with straightforward one‐step microwave pyrolysis process high quantum yield (63.8%). After being excited at λ = 360 nm, the produced displayed maximum bluish fluorescence em 420 nm. Rutin quenched based inner filter effect static quenching processes. Along International Council Harmonization (ICH) requirements, developed spectrofluorometric method was validated. linearity range 0.50–35.00 μg/mL rutin. successfully employed to determine concentrations marketed tablets. is simple, consistent, sensitive, selective, it does not require expensive chemicals or specialized instruments. This study paves path future application NP‐CD pharmaceutical analysis.

Language: Английский

Citations

2
Photonic Nanomaterials for Wearable Health Solutions DOI Creative Commons
Taewoong Park, Jung Woo Leem, Young L. Kim

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Language: Английский

Citations

2
Reproducible, Accurate, and Sensitive Food Toxin On-Site Detection with Carbon Nanotube Transistor Biosensors DOI
Tingxian Li, Zhongyu Li,

Li Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Field-effect transistor (FET) biosensors based on nanomaterials are promising in the areas of food safety and early disease diagnosis due to their ultrahigh sensitivity rapid response. However, most academically developed FET lack real-world reproducibility comprehensive methodological validation meet standards regulatory bodies. Here, highly uniform well-packaged semiconducting carbon nanotube (CNT) biosensor chips were assessed for plug-and-play sensing sensitive detection aflatoxin B1 (AFB1) real samples international standards. In order requirements stability, a scalable residual-free passivation packaging process was CNT biosensors. Portable systems then constructed on-site detection. The resulting packaged functionalized with nucleic aptamers enable selective AFB1 limit (LOD) 0.55 fg/mL (standard) cross-reactivity coefficients interferences as low 1.8 × 10

Language: Английский

Citations

8
Synthesis of green fluorescent carbon dots using cysteine and maltose as ecofriendly ligands for the detection of venlafaxine anti-depression drug in pharmaceutical and plasma samples DOI

Vibhuti Atulbhai Sadhu,

Tae Jung Park, Suresh Kumar Kailasa

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112980 - 112980

Published: Aug. 14, 2024

Language: Английский

Citations

6
Current advancements in nanotechnology for stem cells DOI Creative Commons

P. Thamarai,

S. Karishma,

R. Kamalesh

et al.

International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Language: Английский

Citations

4
Nanoparticle electrochemical biosensors for virus detection DOI

Anandavalli Baskar,

Keerthana Madhivanan,

Raji Atchudan

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 566, P. 120054 - 120054

Published: Nov. 16, 2024

Language: Английский

Citations

4
Self-Assembled PVP-Gd Composite Nanosheets via Ultrasound Synthesis for Targeted Acrylamide Sensing in Food Safety DOI Creative Commons

Sahar Pakbaten Toopkanloo,

Hui‐Fen Wu

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Acrylamide (AM) is a recognized carcinogen and neurotoxin, posing significant threat to food safety human health. Therefore, developing sensitive convenient methods for AM detection in samples essential. This study responds the urgent need selective of AM, hidden hazard food, safeguard public health environmental safety. We present development novel two-dimensional ultrasound-synthesized PVP-Gd composite nanosheet platform precise sensing. These self-assembled nanosheets, constructed from gadolinium (Gd) poly(vinylpyrrolidone) (PVP), exhibit remarkable stability robust blue fluorescence, with quantum yield 45.01% upon excitation at 380 nm. A full factorial design was employed optimize synthesis process, revealing parameter interactions. The optimized nanosheets demonstrated strong quenching effect acrylamide exposure, resulting high-performance sensor an impressively low limit (9.4 nM) broad linear response range. innovative offers promising approach monitoring applications, effectively addressing risks associated acrylamide.

Language: Английский

Citations

0
Tailoring plastic bag derived carbon dots by sulfur-nitrogen passivation for highly selective Fe (III) ion sensing DOI

Ratih Lestari,

Yuichi Κamiya, Tutik Dwi Wahyuningsih

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114187 - 114187

Published: Feb. 1, 2025

Language: Английский

Citations

0
Applications of Green Carbon Dots in Personalized Diagnostics for Precision Medicine DOI Open Access

Habtamu Fekadu Etefa,

F.B. Dejene

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2846 - 2846

Published: March 21, 2025

Green carbon dots (GCDs) have emerged as a revolutionary tool in precision medicine, offering transformative capabilities for personalized diagnostics and therapeutic strategies. Their unique optical biocompatible properties make them ideal non-invasive imaging, real-time monitoring, integration with genomics, proteomics, bioinformatics, enabling accurate diagnosis tailored treatments based on patients’ genetic molecular profiles. This study explores the potential of GCDs advancing individualized patient care by examining their applications medicine. It evaluates utility diagnostic targeted therapy delivery, formulation treatment plans, emphasizing interaction advanced genomic, proteomic, bioinformatics platforms. demonstrated exceptional versatility precise delivering therapies. cutting-edge technologies showed significant promise crafting strategies, enhancing functionality effectiveness monitoring patient-specific applications. The findings underscore pivotal role reshaping healthcare medicine improving outcomes. ongoing development emerging to further enhance capabilities, paving way more effective, medical care.

Language: Английский

Citations

0
Box–Behnken optimized MPA-CdTe quantum dots as turn-off fluorescent probes for sensitive lurasidone determination in pharmaceutical, biological, and environmental matrices DOI Creative Commons

Razaz Felemban,

Maram H. Abduljabbar, Reem M. Alnemari

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(12), P. 8855 - 8866

Published: Jan. 1, 2025

A sensitive “turn-off” fluorescent method using MPA-CdTe quantum dots was developed for the selective determination of lurasidone in pharmaceutical formulations, spiked plasma, and environmental water samples.

Language: Английский

Citations

0