Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Magnetoliposomes represent a transformative advancement in nanomedicine by integrating magnetic nanoparticles with liposomal structures, creating multifunctional delivery platforms that overcome key limitations of conventional drug carriers. These hybrid systems enable precision targeting through external fields, controlled release via hyperthermia, and real-time theranostic capabilities, offering unprecedented spatiotemporal control over therapeutic administration. This manuscript focused primarily on studies from 2023-2025 however, few select older references were included to provide background context.This review examines the fundamental design principles Magnetoliposomes, including bilayer composition, nanoparticle integration strategies, physicochemical properties governing their biological performance. We comprehensively assess synthesis methodologies - traditional thin-film hydration advanced microfluidic approaches highlighting impact colloidal stability, encapsulation, scaling potential. Characterization techniques essential for quality regulatory approval are systematically reviewed, followed applications across oncology, gene delivery, neurology, infectious disease treatment, supported recent experimental evidence. While magnetoliposomes show remarkable versatility, clinical translation requires addressing biocompatibility concerns, manufacturing scalability, hurdles. Integration artificial intelligence, organ-on-chip technologies, personalized medicine will likely accelerate development toward reality, potentially revolutionizing treatment paradigms complex diseases tailored interventions.

Language: Английский