Cited by Vitamin A Deficiency, COVID-19, and Rhino-Orbital Mucormycosis (Black Fungus): An Analytical Perspective

Exploring Niclosamide as a Multi-target Drug Against SARS-CoV-2: Molecular Dynamics Simulation Studies on Host and Viral Proteins DOI

Prachi Jagtap,

Virendra Kumar Meena,

Susmit B. Sambhare

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Language: Английский

Citations

Drug Repositioning as an Antiviral Strategy Against Emerging Viruses DOI

Selvin Noé Palacios-Rápalo, Carlos Daniel Cordero‐Rivera, Luis Adrián De Jesús‐González

et al.

The Latin American studies book series, Journal Year: 2024, Volume and Issue: unknown, P. 273 - 317

Published: Jan. 1, 2024

Language: Английский

Citations

Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response DOI

Yining Wang, Pengfei Li, Lei Xu

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(9), P. 107631 - 107631

Published: Aug. 16, 2023

Severe infections with coronaviruses are often accompanied hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral agents library, we identified that indomethacin can inhibit pan-coronavirus infection in human cell airway organoids models. Combining oral drugs authorized for treating COVID-19 results synergistic anti-coronavirus activity. Coincidentally, library of FDA-approved as most potent potentiator interferon response through increasing STAT1 phosphorylation. interferon-alpha exerted effects against multiple coronaviruses. The activity is associated activating response. In co-culture system lung epithelial cells macrophages, inhibited both viral replication inflammatory Collectively, inhibitor virus-triggered potential be further augmented by combining it or interferon-alpha.

Language: Английский

Citations

Antiviral Activity Against SARS-CoV-2 Variants Using in Silico and in Vitro Approaches DOI

Hee-Jung Lee, Hanul Choi,

Aleksandra Nowakowska

et al.

The Journal of Microbiology, Journal Year: 2023, Volume and Issue: 61(7), P. 703 - 711

Published: June 26, 2023

Language: Английский

Citations

Computational Insights on Solvation and Hydrogen Bonding Studies of Indomethacin DOI

B. Yogeswari,

S. Deivanayaki,

A. Sajitha Banu

et al.

Asian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 35(4), P. 861 - 868

Published: March 30, 2023

Over a long time, non-steroidal anti-inflammatory drugs (NSAIDs) play vital role in medical field. Indomethacin is NSAID mainly used against inflammation and pain. But the poor solubility of indomethacin limits its therapeutic usage. Hydrotropy solubilization technique to enhance drug solubilization. Microscopic solvent effect considered be part hydrotropy which hydrogen bond (H-bond) networks are formed with an isolated molecule molecules such as water. A comprehensive theoretical investigation was performed under density functional theory (DFT) explore monohydrated complexes. The geometries were optimized on B3LYP method 6-311G (2d,2p) basis set. interaction energies hydrated complexes computed by correcting set superposition error. Natural orbital (NBO) study order deepen knowledge O-H···O C-H···O type H-bonds. linear relationship between H-bond length stabilization energy (E(2))was observed solvated correlation coefficient 0.8346. It identifies maximum E(2) (95.33 Kcal/mol) INDO-12 complex. molecular electrostatic potential mapping (MESP) for structures also analyzed.

Language: Английский

Citations

Vitamin A Deficiency, COVID-19, and Rhino-Orbital Mucormycosis (Black Fungus): An Analytical Perspective DOI

Aziz Rodan Sarohan,

Sait Edipsoy,

Zeynep Özkurt

et al.

Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 153 - 166

Published: Jan. 1, 2023

Language: Английский

Citations