Plasma and urinary metabolomic signatures differentiate genetic and idiopathic Parkinson’s disease
Brain Research,
Journal Year:
2025,
Volume and Issue:
1858, P. 149625 - 149625
Published: April 17, 2025
Language: Английский
Comparison of AI with and without hand-crafted features to classify Alzheimer's disease in different languages
T Kim,
No information about this author
Junhyeok Son,
No information about this author
Ji‐Won Chun
No information about this author
et al.
Computers in Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
180, P. 108950 - 108950
Published: Aug. 2, 2024
Language: Английский
Understanding the (epi)genetic dysregulation in Parkinson's disease through an integrative brain competitive endogenous RNA network
Rafael Mina Piergiorge,
No information about this author
Ana Tereza Ribeiro de Vasconcelos,
No information about this author
Cíntia Barros Santos-Rebouças
No information about this author
et al.
Mechanisms of Ageing and Development,
Journal Year:
2024,
Volume and Issue:
219, P. 111942 - 111942
Published: May 16, 2024
Language: Английский
Exploring cross-tissue DNA methylation patterns: blood–brain CpGs as potential neurodegenerative disease biomarkers
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: July 26, 2024
Abstract
The
difficulty
of
obtaining
samples
from
certain
human
tissues
has
led
to
efforts
find
accessible
sources
analyze
molecular
markers
derived
DNA.
In
this
study,
we
look
for
DNA
methylation
patterns
in
blood
and
its
association
with
the
brain
pattern
neurodegenerative
disorders.
Using
data
databases,
selected
18,293
CpGs
presenting
correlated
levels
between
(bb-CpGs)
compare
their
level
patients
diseases
(Alzheimer’s
disease,
Parkinson’s
Multiple
Sclerosis,
X
Fragile
Syndrome)
healthy
controls.
Sixty-four
bb-CpGs
presented
significant
distinct
patients,
being:
nine
Alzheimer’s
28
18
Syndrome.
Similar
differences
was
also
observed
when
comparing
tissue
vs.
genomic
regions
some
these
64
are
placed
close
or
inside
genes
previously
associated
respective
condition.
Our
findings
support
rationale
using
as
a
surrogate
changes
CpG
diseases,
opening
possibility
characterizing
new
biomarkers.
Language: Английский
Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 106750 - 106750
Published: Nov. 1, 2024
Language: Английский