Revolutionizing Biomedical Research: Unveiling the Power of Microphysiological Systems with Advanced Assays, Integrated Sensor Technologies, and Real-Time Monitoring DOI Creative Commons

Anupama Samantasinghar,

Naina Sunildutt,

Faheem Ahmed

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(10), P. 9869 - 9889

Published: March 10, 2025

The limitation of animal models to imitate a therapeutic response in humans is key problem that challenges their use fundamental research. Organ-on-a-chip (OOC) devices, also called microphysiological systems (MPS), are devices containing lining living cells grown under dynamic flow recapitulate the important features human physiology and pathophysiology with high precision. Recent advances microfabrication tissue engineering techniques have led wide adoption OOC next-generation experimental platforms. This review presents comprehensive analysis systems, categorizing them by types (single-pass multipass), operational mechanisms (pumpless pump-driven), configurations (single-organ multiorgan systems), along respective advantages limitations. Furthermore, it explores integration qualitative quantitative assay techniques, providing comparative evaluation without sensor integration. aims fill essential knowledge gaps, driving progress development paving way for breakthroughs biomedical research, pharmaceutical innovation, engineering.

Language: Английский

Revolutionizing Biomedical Research: Unveiling the Power of Microphysiological Systems with Advanced Assays, Integrated Sensor Technologies, and Real-Time Monitoring DOI Creative Commons

Anupama Samantasinghar,

Naina Sunildutt,

Faheem Ahmed

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(10), P. 9869 - 9889

Published: March 10, 2025

The limitation of animal models to imitate a therapeutic response in humans is key problem that challenges their use fundamental research. Organ-on-a-chip (OOC) devices, also called microphysiological systems (MPS), are devices containing lining living cells grown under dynamic flow recapitulate the important features human physiology and pathophysiology with high precision. Recent advances microfabrication tissue engineering techniques have led wide adoption OOC next-generation experimental platforms. This review presents comprehensive analysis systems, categorizing them by types (single-pass multipass), operational mechanisms (pumpless pump-driven), configurations (single-organ multiorgan systems), along respective advantages limitations. Furthermore, it explores integration qualitative quantitative assay techniques, providing comparative evaluation without sensor integration. aims fill essential knowledge gaps, driving progress development paving way for breakthroughs biomedical research, pharmaceutical innovation, engineering.

Language: Английский

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