A Simple and Low-cost Method to Develop Porous Egg White Scaffolds with Controllable Shape for Cartilage Regeneration

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112192 - 112192

Published: Feb. 1, 2025

Language: Английский

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Transdermal anti-inflammatory effects and mechanisms of hydrogel patches containing seco-iridoids from Gentiana macrophylla Pall

Fitoterapia, Journal Year: 2025, Volume and Issue: 183, P. 106544 - 106544

Published: April 15, 2025

Language: Английский

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Bone-Targeting Nucleic Acid Delivery Polymer Vector for Effective Therapy of Bone Metastasis

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Bone diseases, such as bone metastases, pose significant therapeutic challenges due to the distinct physiological environment of skeletal tissues, which complicates targeted delivery nucleic acid therapeutics. Existing systems, including lipid nanoparticles (LNP) and polyethylenimine (PEI), struggle achieve precise targeting effectively. To address this issue, we developed a polymer-based bone-targeting bioreducible vector, poly[alendronic acid-co-(N,N'-bis(acryloyl)cystamine-co-4-amino-1-butanol)] (ALN-Pabol), incorporates alendronic (ALN) for targeting. The ALN-Pabol exhibited hydroxyapatite binding rate 91.1%, significantly outperforming nontargeted Pabol/miRNA (73.5%) commercial systems PEI/miRNA (58.3%) Lipofectamine 2000/miRNA (64.7%). In vivo fluorescence imaging demonstrated its superior accumulation compared controls. murine breast cancer metastasis model, ALN-Pabol/miRNA polyplex reduced tumor weight by 79.1% relative PBS controls 36.8% LNP/miRNA. Mechanistically, dissociates in high-glutathione microenvironment, releasing miRNA suppress cell proliferation promote apoptosis. Simultaneously, ALN inhibits osteoclast activity, mitigating osteolytic damage. Micro-CT analysis revealed near-complete restoration volume trabecular architecture healthy levels. This work establishes highly promising vector bone-targeted gene therapy, bridging critical gaps disease treatment expanding potential applications regeneration therapy.

Language: Английский

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Micro-structure modified decalcified bone matrix scaffolds and bone marrow stem cell–chondrocyte co-cultures promote stable cartilage regeneration

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 291, P. 111976 - 111976

Published: Nov. 16, 2024

Language: Английский

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Gradient-Coated Radial-Structured Scaffolds for Rapid Dural Regeneration: Providing fast migration pathways and strong migration dynamics

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 291, P. 111975 - 111975

Published: Nov. 13, 2024

Language: Английский

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