Altered food liking in depression is driven by macronutrient composition DOI Creative Commons

Lilly Thurn,

Corinna Schulz, Diba Borgmann

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Major depressive disorder (MDD) is characterized by changes in appetite and body weight as well blunted reward sensitivity (“anhedonia”). However, it not understood which mechanisms are driving sensitivity, specifically regarding food. Here, we used a sample of 117 participants (54 patients with MDD; 63 healthy control participants, HCP) who completed food cue reactivity (FCR) task ratings wanting liking for 60 20 non-food items. To evaluate components the may contribute to altered depression, tested associations macronutrients depicted In line previous studies, found reduced ( p = .003), but .23) MDD compared matched HCPs. Adding macronutrient composition models substantially improved their fit s < .001). Compared carbohydrate-rich foods, reported lower high-fat high-protein foods. Moreover, showed weaker correlations preferences carbohydrate-versus fat- or protein-rich foods .001), pointing potential disturbances metabolic signaling. conclude, our results suggest that depression-related alterations more specific than previously anticipated, hinting at gut-brain These findings raise intriguing question whether interventions targeting gut could help normalize aberrant signals rich fat protein. Figure

Language: Английский

Altered food liking in depression is driven by macronutrient composition DOI Creative Commons

Lilly Thurn,

Corinna Schulz, Diba Borgmann

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Major depressive disorder (MDD) is characterized by changes in appetite and body weight as well blunted reward sensitivity (“anhedonia”). However, it not understood which mechanisms are driving sensitivity, specifically regarding food. Here, we used a sample of 117 participants (54 patients with MDD; 63 healthy control participants, HCP) who completed food cue reactivity (FCR) task ratings wanting liking for 60 20 non-food items. To evaluate components the may contribute to altered depression, tested associations macronutrients depicted In line previous studies, found reduced ( p = .003), but .23) MDD compared matched HCPs. Adding macronutrient composition models substantially improved their fit s < .001). Compared carbohydrate-rich foods, reported lower high-fat high-protein foods. Moreover, showed weaker correlations preferences carbohydrate-versus fat- or protein-rich foods .001), pointing potential disturbances metabolic signaling. conclude, our results suggest that depression-related alterations more specific than previously anticipated, hinting at gut-brain These findings raise intriguing question whether interventions targeting gut could help normalize aberrant signals rich fat protein. Figure

Language: Английский

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