Adaptation of spontaneous activity in the developing visual cortex DOI Creative Commons
Marina E. Wosniack, Jan H. Kirchner, Ling-Ya Chao

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: March 16, 2021

Spontaneous activity drives the establishment of appropriate connectivity in different circuits during brain development. In mouse primary visual cortex, two distinct patterns spontaneous occur before vision onset: local low-synchronicity events originating retina and global high-synchronicity cortex. We sought to determine contribution these jointly organize network through activity-dependent plasticity rules. postulated that shape cortical input selectivity topography, while homeostatically regulate connection strength. However, generate robust selectivity, we found should adapt their amplitude history preceding activation. confirmed this prediction by analyzing vivo activity. The predicted adaptation leads sparsification on a slower timescale development, demonstrating remarkable capacity developing sensory cortex acquire sensitivity inputs after eye-opening.

Language: Английский

Interneuron Types as Attractors and Controllers DOI
Gord Fishell, Ádám Kepecs

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 43(1), P. 1 - 30

Published: July 12, 2019

Cortical interneurons display striking differences in shape, physiology, and other attributes, challenging us to appropriately classify them. We previously suggested that interneuron types should be defined by their role cortical processing. Here, we revisit the question of how codify diversity based upon division labor function as controllers information flow. suggest developmental trajectories provide a guide for appreciating argue subtype identity is generated using configurational (rather than combinatorial) code transcription factors produce attractor states underlying gene regulatory network. present our updated three-stage model specification: an initial cardinal step, allocating into few major classes, followed definitive refinement, creating subclasses settling within cortex, lastly, state determination, reflecting incorporation functional circuit ensembles. close discussing findings indicating classes are both evolutionarily ancient conserved. propose complexity circuits phylogenetically old types, complemented evolutionary increase principal neuron diversity. This suggests natural neurobiological definition might derived from match between origin computational function.

Language: Английский

Citations

173
Inhibitory stabilization and cortical computation DOI
Sadra Sadeh, Claudia Clopath

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 22(1), P. 21 - 37

Published: Nov. 11, 2020

Language: Английский

Citations

165
Hearing loss and brain plasticity: the hyperactivity phenomenon DOI
Björn Herrmann, Blake E. Butler

Brain Structure and Function, Journal Year: 2021, Volume and Issue: 226(7), P. 2019 - 2039

Published: June 7, 2021

Language: Английский

Citations

62
Synapse-type-specific competitive Hebbian learning forms functional recurrent networks DOI Creative Commons
Samuel Eckmann, Edward Young, Julijana Gjorgjieva

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(25)

Published: June 13, 2024

Cortical networks exhibit complex stimulus–response patterns that are based on specific recurrent interactions between neurons. For example, the balance excitatory and inhibitory currents has been identified as a central component of cortical computations. However, it remains unclear how required synaptic connectivity can emerge in developing circuits where synapses neurons simultaneously plastic. Using theory modeling, we propose wide range response properties arise from single plasticity paradigm acts at all connections—Hebbian learning is stabilized by synapse-type-specific competition for limited supply resources. In plastic circuits, this enables formation decorrelation inhibition-balanced receptive fields. Networks develop an assembly structure with stronger connections similarly tuned normalization orientation-specific center-surround suppression, reflecting stimulus statistics during training. These results demonstrate self-organize into functional suggest essential role competitive development circuits.

Language: Английский

Citations

9
Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility DOI Creative Commons
Xiaohan Zhang, Arghya Mukherjee, Michael M. Halassa

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 18, 2025

The mediodorsal (MD) thalamus is a critical partner for the prefrontal cortex (PFC) in cognitive control. Accumulating evidence has shown that MD regulates task uncertainty decision making and enhance flexibility. However, computational mechanism of this process remains unclear. Here we trained biologically-constrained models to delineate mechanistic role context-dependent making. We show addition feedforward structure recurrent PFC increases robustness low cueing signal-to-noise ratio, enhances working memory, enables rapid context switching. Incorporating genetically identified thalamocortical connectivity interneuron cell types into model replicates key neurophysiological findings task-performing animals. Our reveals mechanisms geometric interpretations regulating cue switching enable makes experimentally testable predictions linking deficits with disrupted connectivity, excitation-inhibition imbalance dysfunctional inhibitory types. by which activity flexibility not fully understood. authors build incorporating Together experimental testing, circuit

Language: Английский

Citations

1
Auditory cortex shapes sound responses in the inferior colliculus DOI Creative Commons
Jennifer M. Blackwell, Alexandria M.H. Lesicko,

Winnie Rao

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Jan. 31, 2020

The extensive feedback from the auditory cortex (AC) to inferior colliculus (IC) supports critical aspects of behavior but has not been extensively characterized. Previous studies demonstrated that activity in IC is altered by focal electrical stimulation and pharmacological inactivation AC, these methods lack ability selectively manipulate projection neurons. We measured effects selective optogenetic modulation cortico-collicular projections on sound responses mice. Activation increased spontaneous decreased stimulus selectivity IC, whereas suppression had no effect. To further understand how microcircuits AC may control collicular activity, we optogenetically modulated different cortical neuronal subtypes, specifically parvalbumin-positive (PV) somatostatin-positive (SST) inhibitory interneurons. found modulating either type interneuron did affect sound-evoked activity. Combined, our results identify activation excitatory projections, inhibition-driven changes affects responses.

Language: Английский

Citations

67
Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology DOI Creative Commons
Zeynep I. Gunes,

Vanessa W. Y. Kan,

XiaoQian Ye

et al.

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: June 17, 2020

Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of both upper and lower motor neurons. Despite decades research, we still to date lack cure or disease modifying treatment, emphasizing need for much-improved insight into mechanisms cell type vulnerability. Altered neuronal excitability common phenomenon reported in ALS patients, as well animal models but cellular circuit processes involved, causal relevance those observations molecular alterations typical final death, remain poorly understood. Here, review evidence from clinical studies, specific electrophysiological recordings, genetic manipulations characterizations culture experiments, arguing complex structure, function connectivity different subtypes within cortical spinal cord circuitries. We also summarize current knowledge regarding detrimental role astrocytes reassess frequently proposed hypothesis glutamate-mediated excitotoxicity with respect changes excitability. Together, these findings suggest multifaceted type- , brain area- stage- disturbances excitation/inhibition balance cardinal aspect pathophysiology.

Language: Английский

Citations

56
AgeAnno: a knowledgebase of single-cell annotation of aging in human DOI Creative Commons
Kexin Huang,

Hoaran Gong,

Jingjing Guan

et al.

Nucleic Acids Research, Journal Year: 2022, Volume and Issue: 51(D1), P. D805 - D815

Published: Oct. 6, 2022

Abstract Aging is a complex process that accompanied by molecular and cellular alterations. The identification of tissue-/cell type-specific biomarkers aging elucidation the detailed biological mechanisms aging-related genes at single-cell level can help to understand heterogeneous design targeted anti-aging therapeutics. Here, we built AgeAnno (https://relab.xidian.edu.cn/AgeAnno/#/), knowledgebase single cell annotation in human, aiming provide comprehensive characterizations for across diverse tissue-cell types human using RNA ATAC sequencing data (scRNA scATAC). current version houses 1 678 610 cells from 28 healthy tissue samples with ages ranging 0 110 years. We collected 5580 previous resources performed dynamic functional annotations context. For scRNA data, analyses include differential gene expression, variation coefficient, communication network, transcription factor (TF) regulatory immune proportionc. also provides chromatin accessibility analysis, motif/TF enrichment footprint co-accessibility peak analysis scATAC data. will be unique resource systematically characterize it could facilitate antiaging disease research.

Language: Английский

Citations

29
Sensory processing deficits and related cortical pathological changes in Alzheimer’s disease DOI Creative Commons
Nicole K. Zhang,

Selena K. Zhang,

Li I. Zhang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Aug. 15, 2023

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily affecting cognitive functions. However, sensory deficits in AD start to draw attention due their high prevalence and early onsets which suggest that they could potentially serve as diagnostic biomarkers even contribute the progression. This literature review examines cortical pathological changes observed visual, auditory, olfactory, somatosensory systems patients, well various animal models. Sensory may emerge at stages of AD, or precede decline, accompanied by including amyloid-beta deposition, tauopathy, gliosis, alterations neuronal excitability, synaptic inputs, functional plasticity. Notably, these are more pronounced association areas superficial layers, explain relative preservation basic functions but display higher We propose impairment progression establish cyclical relationship mutually perpetuates each condition. highlights significance with without emphasizes need for further research develop reliable detection intervention through systems.

Language: Английский

Citations

17
The developing brain revealed during sleep DOI
Mark S. Blumberg, James C. Dooley, Greta Sokoloff

et al.

Current Opinion in Physiology, Journal Year: 2019, Volume and Issue: 15, P. 14 - 22

Published: Nov. 18, 2019

Language: Английский

Citations

49