Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Jan. 9, 2020

Inhibitory autapses are self-innervating synaptic connections in GABAergic interneurons the brain. Autapses neocortical layers have not been systematically investigated, and their function different mammalian species specific interneuron types is poorly known. We investigated parvalbumin-expressing basket cells (pvBCs) layer 2/3 (L2/3) human tissue resected deep-brain surgery, mice as control. Most pvBCs showed robust GABAAR-mediated self-innervation both species, but were rare nonfast-spiking interneurons. Light- electron microscopy analyses revealed pvBC axons innervating own soma proximal dendrites. self-inhibition conductance was similar mouse comparable to that of synapses from other L2/3 neurons. Autaptic prolonged somatic inhibition after a spike inhibited repetitive firing. Perisomatic autaptic common supragranular neocortex, where they efficiently control discharge pvBCs.

Language: Английский

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Maternal Experience-Dependent Cortical Plasticity in Mice Is Circuit- and Stimulus-Specific and Requires MECP2

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(7), P. 1514 - 1526

Published: Jan. 7, 2020

The neurodevelopmental disorder Rett syndrome is caused by mutations in the gene Mecp2 Misexpression of protein MECP2 thought to contribute neuropathology causing dysregulation plasticity. Female heterozygous mutants (Mecp2het ) failed acquire a learned maternal retrieval behavior when exposed pups, an effect linked disruption parvalbumin-expressing inhibitory interneurons (PV) auditory cortex. Nevertheless, how dysregulated PV networks affect neural activity dynamics that underlie cortical plasticity during early experience unknown. Here we show WT adult female mice (WT) triggers suppression responses. We also observe concomitant disinhibition responses deep-layer pyramidal neurons selective for behaviorally relevant pup vocalizations. These further exhibit sharpened tuning vocalizations following experience. All these neuronal changes are abolished Mecp2het , suggesting they essential component learning. This supported our finding genetic manipulation GABAergic restores accurate experience-dependent PV. Our data consistent with growing body evidence particularly vulnerable neurons. Moreover, work links, first time, impaired vivo awake mutant animals natural, ethologically behavior.SIGNIFICANCE STATEMENT includes language communication problems. Nearly all produces MECP2, which important brain connectivity believed previously showed fail learn simple care performed response their pups' distress cries. impairment appeared critically involve cortex called parvalbumin record from before and after experience, adapt calls learning nonmutants, but not mutants. adaptation partially restored improves

Language: Английский

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Untangling stability and gain modulation in cortical circuits with multiple interneuron classes

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: June 15, 2020

Synaptic inhibition is the mechanistic backbone of a suite cortical functions, not least which are maintaining network stability and modulating neuronal gain. In models with single inhibitory neuron class, stabilization gain control work in opposition to one another -- meaning high coincides low vice versa. It now clear that diverse, molecularly distinguished cell classes having distinct positions within circuit. We analyze circuit pyramidal neurons (E) as well parvalbumin (PV) somatostatin (SOM) expressing interneurons. show how E PV SOM recurrently connected networks an SOM-mediated modulation can lead simultaneous increases stability. Our exposes impact mediated by depends critically on connectivity state.

Language: Английский

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Adaptation of spontaneous activity in the developing visual cortex

eLife, Journal Year: 2021, Volume and Issue: 10

Published: March 16, 2021

Spontaneous activity drives the establishment of appropriate connectivity in different circuits during brain development. In mouse primary visual cortex, two distinct patterns spontaneous occur before vision onset: local low-synchronicity events originating retina and global high-synchronicity cortex. We sought to determine contribution these jointly organize network through activity-dependent plasticity rules. postulated that shape cortical input selectivity topography, while homeostatically regulate connection strength. However, generate robust selectivity, we found should adapt their amplitude history preceding activation. confirmed this prediction by analyzing vivo activity. The predicted adaptation leads sparsification on a slower timescale development, demonstrating remarkable capacity developing sensory cortex acquire sensitivity inputs after eye-opening.

Language: Английский

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Inhibition in the auditory cortex

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 132, P. 61 - 75

Published: Nov. 22, 2021

The auditory system provides us with extremely rich and precise information about the outside world. Once a sound reaches our ears, acoustic it carries travels from cochlea all way to cortex, where its complexity nuances are integrated. In functional circuits formed by subpopulations of intermingled excitatory inhibitory cells. this review, we discuss recent evidence specific contributions neurons in processing integration. We first examine intrinsic properties three main classes interneurons cortex. Then, describe how inhibition shapes responsiveness cortex sound. Finally, contribute sensation perception sounds. Altogether, review points out crucial role cortical integrating context, history, or meaning It also highlights open questions be addressed for increasing understanding staggering leading subtlest perception.

Language: Английский

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