The Neurobiology of Parenting and Infant-Evoked Aggression DOI
Harris S. Kaplan, Patricia M. Horvath, Mohammed Mostafizur Rahman

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 105(1), P. 315 - 381

Published: Aug. 15, 2024

Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization individual priorities physiology is facilitated by combinatorial hormone action on specific cell types that are integrated throughout interconnected brainwide neuronal circuits. In this review, we take comprehensive approach integrate historical current literature each these topics species, with focus rodents. New emerging molecular, circuit-based, computational technologies have recently been used address outstanding gaps in our framework knowledge infant-directed behavior. This work raising fundamental questions about the interplay between instinctive learned components parenting mutual regulation affiliative versus agonistic behaviors health disease. Whenever possible, point how helped gain novel insights opened new avenues research into neurobiology parenting. We hope review will serve as introduction for those field, resource already studying parenting, guidepost designing future studies.

Language: Английский

In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium DOI Creative Commons
Young‐Geun Park, Yong Won Kwon, Chin Su Koh

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 27, 2024

Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which deteriorate the integrity of device biological systems and restrict free behavior subject. We report soft, conformable interface system that can monitor single-unit activities neurons with long-term stability. The implements in brain, their subsidiary directly printed on cranial surface. high-resolution printing liquid metals forms cellular-scale diameter adaptable lengths. Also, metal-based circuits interconnections along curvature cranium enables conformal integration circuit delivers signals smartphone wirelessly. In in-vivo studies using mice, demonstrates recording (33 weeks) arbitrary brain regions. T-maze behavioral tests, shows behavior-induced activation multiple

Language: Английский

Citations

18
Prey capture learning drives critical period-specific plasticity in mouse binocular visual cortex DOI Creative Commons
Diane Bissen, Brian Cary, Amanda Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Summary Critical periods are developmental windows of high experience-dependent plasticity essential for the correct refinement neuronal circuitry and function. While consequences visual system sensory deprivation during critical period have been well-characterized, far less is known about effects enhanced experience. Here, we use prey capture learning to assess structural functional mediating in primary cortex mice. We show that improves temporal frequency discrimination drives a profound remodeling through an increase excitatory connectivity spine turnover. This global persistent rewiring not observed adult hunters mediated by TNFα-dependent mechanisms. Our findings demonstrate experience naturalistic paradigm can drive improve function, promotes long-lasting dynamics could enhance subsequent plasticity.

Language: Английский

Citations

3
The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes DOI Creative Commons
Edward Zagha, Jeffrey C. Erlich, Soo‐Hyun Lee

et al.

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(8), P. 1375 - 1382

Published: Jan. 13, 2022

A surprising finding of recent studies in mouse is the dominance widespread movement-related activity throughout brain, including early sensory areas. In awake subjects, failing to account for movement risks misattributing other (e.g., or cognitive) processes. this article, we (1) review task designs separating task-related and activity, (2) three “case studies” which not considering would have resulted critically different interpretations neuronal function, (3) discuss functional couplings that may prevent us from ever fully isolating sensory, motor, cognitive-related activity. Our main thesis neural signals related are ubiquitous, therefore ought be considered first foremost when attempting correlate with

Language: Английский

Citations

70
Human cortical dynamics during full-body heading changes DOI Creative Commons
Klaus Gramann,

Friederike U. Hohlefeld,

Lukas Gehrke

et al.

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Sept. 14, 2021

The retrosplenial complex (RSC) plays a crucial role in spatial orientation by computing heading direction and translating between distinct reference frames based on multi-sensory information. While invasive studies allow investigating computation moving animals, established non-invasive analyses of human brain dynamics are restricted to stationary setups. To investigate the RSC actively humans, we used Mobile Brain/Body Imaging approach synchronizing electroencephalography with motion capture virtual reality. Data from physically rotating participants were contrasted rotations only visual flow. During physical rotation, varying rotation velocities accompanied pronounced wide frequency band synchronization RSC, parietal occipital cortices. In contrast, flow condition was associated alpha desynchronization, replicating previous findings desktop navigation studies, notably absent during rotation. These results suggest an involvement visual, vestibular, proprioceptive input implicate revisiting traditional desynchronization areas network movement-restricted participants.

Language: Английский

Citations

48
Spatial modulation of visual responses arises in cortex with active navigation DOI Creative Commons
E. Mika Diamanti, Charu Bai Reddy, Sylvia Schröder

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Feb. 4, 2021

During navigation, the visual responses of neurons in mouse primary cortex (V1) are modulated by animal’s spatial position. Here we show that this modulation is similarly present across multiple higher areas but negligible main thalamic pathway into V1. Similar to hippocampus, strengthens with experience and active behavior. Active navigation a familiar environment, therefore, enhances signals starting cortex.

Language: Английский

Citations

43
Spatial Representations in Rat Orbitofrontal Cortex DOI Open Access
Andrew M. Wikenheiser, Matthew P.H. Gardner, Lauren Mueller

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(32), P. 6933 - 6945

Published: July 1, 2021

The orbitofrontal cortex (OFC) and hippocampus share striking cognitive functional similarities. As a result, both structures have been proposed to encode "cognitive maps" that provide useful scaffolds for planning complex behaviors. However, while this function has exemplified by spatial coding in neurons of hippocampal regions—particularly place grid cells—spatial representations the OFC investigated far less. Here we sought address recording from male rats engaged an open-field foraging task like originally developed characterize fields rodent neurons. Single-unit activity was recorded as searched food pellets scattered randomly throughout large enclosure. In some sessions, particular flavors occurred more frequently parts enclosure; others, only single flavor used. showed spatially localized firing conditions, changed between flavored unflavored periods manner reminiscent remapping hippocampus. Compared with recordings taken under similar behavioral were less temporally reliable, there no significant evidence tuning These data confirm show large, two-dimensional environment Consistent focus on biological meaning goals, weaker than influenced outcome identity. SIGNIFICANCE STATEMENT This is cells identified hippocampus, which maps environments. current study directly demonstrates very similar, though not identical, representatives neurons, confirming OFC—like hippocampus—can represent map appropriate experimental conditions.

Language: Английский

Citations

42
Interactions between rodent visual and spatial systems during navigation DOI
Aman B. Saleem, Laura Busse

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(8), P. 487 - 501

Published: June 28, 2023

Language: Английский

Citations

20
Neuronal sensorimotor integration guiding salt concentration navigation in Caenorhabditis elegans DOI Creative Commons

Ayaka Matsumoto,

Yu Toyoshima, Chenqi Zhang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(5)

Published: Jan. 22, 2024

Animals navigate their environment by manipulating movements and adjusting trajectory which requires a sophisticated integration of sensory data with current motor status. Here, we utilize the nematode Caenorhabditis elegans to explore neural mechanisms processing information for navigation. We developed microfluidic device allows animals freely move heads while receiving temporal NaCl stimuli. found that C. regulates neck bending direction in response concentration changes way is consistent ’ navigational strategy traveling toward preferred concentrations. Our analysis also revealed activity neuron significantly correlated activated decrease phase-dependent manner. By combining behavioral stimuli optogenetic perturbation experiments, during ventral activates counteracts ipsilateral bending. Simulations further suggest this neurons can facilitate curving salt

Language: Английский

Citations

8
Layer 1 neocortex: Gating and integrating multidimensional signals DOI Creative Commons
Shuhan Huang, Jingjing Sherry Wu, Giulia Sansone

et al.

Neuron, Journal Year: 2023, Volume and Issue: 112(2), P. 184 - 200

Published: Oct. 31, 2023

Language: Английский

Citations

15
Natural visual behavior and active sensing in the mouse DOI Creative Commons
Rolf Skyberg, Cristopher M. Niell

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 86, P. 102882 - 102882

Published: May 4, 2024

In the natural world, animals use vision for a wide variety of behaviors not reflected in most laboratory paradigms. Although mice have low-acuity vision, they their many behaviors, including predator avoidance, prey capture, and navigation. They also perform active sensing, moving head eyes to achieve behavioral goals acquire visual information. These aspects result inputs corresponding outputs that are outside range conventional studies but essential function. Here, we review recent tapped into behavior sensing reveal computational logic neural circuits vision.

Language: Английский

Citations

4