Development of the rodent prefrontal cortex: circuit formation, plasticity, and impacts of early life stress DOI Creative Commons
Xinyi Chen, Yuri Kim, Daichi Kawaguchi

et al.

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 19

Published: March 26, 2025

The prefrontal cortex (PFC), located at the anterior region of cerebral cortex, is a multimodal association essential for higher-order brain functions, including decision-making, attentional control, memory processing, and regulation social behavior. Structural, circuit-level, functional abnormalities in PFC are often associated with neurodevelopmental disorders. Here, we review recent findings on postnatal development PFC, particular emphasis rodent studies, to elucidate how its structural circuit properties established during critical developmental windows these processes influence adult behaviors. Recent evidence also highlights lasting effects early life stress structure, connectivity, function. We explore potential mechanisms underlying stress-induced alterations, focus epigenetic implications maturation By integrating insights, this provides an overview shaping their health disease.

Language: Английский

Development of the rodent prefrontal cortex: circuit formation, plasticity, and impacts of early life stress DOI Creative Commons
Xinyi Chen, Yuri Kim, Daichi Kawaguchi

et al.

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 19

Published: March 26, 2025

The prefrontal cortex (PFC), located at the anterior region of cerebral cortex, is a multimodal association essential for higher-order brain functions, including decision-making, attentional control, memory processing, and regulation social behavior. Structural, circuit-level, functional abnormalities in PFC are often associated with neurodevelopmental disorders. Here, we review recent findings on postnatal development PFC, particular emphasis rodent studies, to elucidate how its structural circuit properties established during critical developmental windows these processes influence adult behaviors. Recent evidence also highlights lasting effects early life stress structure, connectivity, function. We explore potential mechanisms underlying stress-induced alterations, focus epigenetic implications maturation By integrating insights, this provides an overview shaping their health disease.

Language: Английский

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