Environmental enrichment for neuropathic pain via modulation of neuroinflammation

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: March 21, 2025

Neuropathic pain causes tremendous biological and psychological suffering to patients worldwide. Environmental enrichment (EE) is a promising non-pharmacological strategy with high cost-effectiveness reduce neuropathic support rehabilitation therapy. Three researchers reviewed previous studies determine the efficacy of EE for research how improves through neuroinflammation. For this review, Embase, PubMed, Cochran were searched. authors did study selection data extraction. Out 74 papers, 7 met inclusion criteria. In chronic constriction injury rats acute or detrimental stimulation, change behavior was influenced by environmental settings like start time, cage size. Besides, physical has larger effect than socially in inflammatory pain. These articles suggest employing various regulate release pain-causing substances changes ion channels peripheral central nerves improve depression anxiety conditions. The existing proof provides important knowledge upcoming preclinical investigations practical use clinical treatment. This analysis aids advancement improved approaches managing pain, focus on internal mechanisms controlling

Language: Английский

Neurosteroids as emerging therapeutics for treatment-resistant depression: Mechanisms and clinical potential

Neuroscience, Journal Year: 2025, Volume and Issue: 577, P. 300 - 314

Published: May 19, 2025

Language: Английский