Can Intelligent Manufacturing Drive Green Development in China’s Pharmaceutical Industry? -- Evidence from Listed Enterprises

Energy, Journal Year: 2024, Volume and Issue: 308, P. 132953 - 132953

Published: Aug. 23, 2024

Language: Английский

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Biotechnology Methods for API Removal From Pharmaceutical Wastewater

Advances in environmental engineering and green technologies book series, Journal Year: 2025, Volume and Issue: unknown, P. 299 - 336

Published: Jan. 16, 2025

In recent decades, the use of pharmaceutical products has been increased tremendously with over thirty million tons pharmaceuticals are consumed worldwide. Pharmacological drugs have a crucial role in preserving health and welfare both humans animals. Many used not completely metabolized human animal body leading to gets accumulated rivers, lakes, drinking water worldwide as persistent organic chemicals causing severe damage aquatic ecosystems. This chapter analyses several biotechnology methods employed remove APIs from wastewater, specifically emphasizing biological treatments that harness capabilities microorganisms enzymes. The present paper provides thorough analysis microbial degradation, bioaugmentation, application bioreactors. Furthermore, it highlights efficacy, challenges, potential for integration into existing treatment systems (Figure 1).

Language: Английский

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Pillars of Sustainable Pharmaceutical Development

Published: Jan. 1, 2025

Language: Английский

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Need for life cycle assessment of pharmaceuticals for kidney healthcare

Clinical and Experimental Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Purpose Global warming is a known risk factor for chronic kidney disease (CKD), and both progression of the its treatment place burden on environment. Life cycle assessment (LCA) an established method evaluating global impact manufactured products, from materials’ procurement to disposal. We aimed examine available reports application pharmaceuticals. Methods A narrative review focused LCA studies any pharmaceuticals according area. Results identified drug types used 13 areas described in 51 previous studies, classified using MIDAS database. Among types, anesthetics, inhalants, antibiotics have received most attention. However, are lacking wide range healthcare, fields dialysis therapy, end-stage disease, associated cardiovascular, metabolic, endocrine diseases. Discussion As proportion population affected by CKD increases, there particular urgency research into drugs administered their protective effects, such as renin-–angiotensin system inhibitors sodium-glucose cotransporter 2 inhibitors. sustainable practices production ability identify choose effective with low environmental require comprehensive data, clinical physicians pharmacists involved healthcare should collaborate pharmaceutical companies develop . Incorporating rating each daily practice desirable achieving reducing impacts.

Language: Английский

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Illuminating Communication: Advances in Optoelectronics for Information Technologies

Published: Jan. 1, 2025

Language: Английский

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Designing biodegradable aqueous biphasic systems for the selective separation of enzymes

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 353, P. 128508 - 128508

Published: June 26, 2024

In this work, the salting-out strength of reline eutectic mixture in aqueous solution non-ionic surfactant Triton X-102 has been demonstrated at temperatures between 298.15 and 323.15 K as a preliminary step to be employed downstream operations biotechnological process. The phase diagrams data reline-based Aqueous Two Phase Systems (ATPS) have correlated using empirical models based on exponential polynomial equations. tie-lines empirically ascertained through physical properties characterization Othmer-Tobias equation was proposed correlate those data. After having studied effect two model enzymes (protease lipase), performance ATPS for selectively separating them evaluated three different feed compositions same tie-line, demonstrating their pertinence segregate lipase one phases (yield about 95 %) protease other 98 %). These promising results are interesting application reactions where proteases proved deleterious lipases activity, biocompatibility platform does not involve drastic negative effects any enzymes.

Language: Английский

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Comprehensive stimulation of the pharmaceutical industry as a factor in ensuring drug safety in the Russian Federation

Национальная безопасность / nota bene, Journal Year: 2024, Volume and Issue: 3, P. 40 - 61

Published: March 1, 2024

The subject of the study is comprehensive support tools based on example a SPIC, various aspects conclusion requirements for companies when concluding SPIC in relation to pharmaceutical industry. purpose analyze complex tools, identify problems analysis using author examines detail such features as: tax and non-tax benefits concepts "obligations" price regulation medicines from list VED, administrative barriers, opacity an investment project within framework penalties deviations targets, etc. other matters. This was conducted basis application general scientific research methods, including systematic, logical, comparative analysis, method analogy. main conclusions are relevance SPIC. currently important tool both state companies, as it offers serious benefits, which has positive effect activity Russian Federation. At same time, highlights relevant issues parties with whom potential investor concludes penalties. novelty lies during that were not previously highlighted, industry, well proposal directions development can increase attractiveness this instrument.

Language: Английский

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High aspect ratio graphene oxide: a highly efficient plasmid DNA deliverer for plant seed

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 6, 2024

Abstract Plant genetic engineering plays a central role in crop improvement and the biosynthesis of natural products. However, plant cell wall serves as barrier that restricts efficient delivery exogenous biomolecules, particularly direct transfer plasmid DNA into seeds. Here, we introduce novel form graphene oxide characterized by high aspect ratio, synthesized through low-voltage, low-current, prolonged electrochemical oxidation 0.5 mol/L NaOH aqueous solution. The ratio (HARGO) can effectively deliver to Poa crymophila Keng seeds, achieving 90% success rate. Furthermore, it is effective for both wheat rice underlying mechanism this HARGO physically absorb transport adsorbed cells deeper tissues passive transport, eliminating need chemical modification polyethylene glycol (PEG) polyethyleneimine (PEI). These findings offer dependable non-integrating tool engineering, which will significantly impact advancement biotechnology.

Language: Английский

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Enzyme Catalysis for Sustainable Value Creation Using Renewable Biobased Resources

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5772 - 5772

Published: Dec. 6, 2024

Enzyme catalysis was traditionally used by various human cultures to create value long before its basic concepts were uncovered. This achieved transforming the raw materials available from natural resources into useful products. Tremendous scientific and technological progress has been made globally in understanding what constitutes an enzyme; reactions enzymes can catalyze; how search, develop, apply, improve make desired The properties of as nature's preferred catalysts, such their high selectivity, diversity, adaptability, enable optimal function, whether single or multiple reactions. Excellent opportunities for resource-efficient manufacturing compounds are provided actions working reaction cascades pathways within same space, like molecular robots along a production line. plays increasingly prominent role industrial innovation responsible areas, green sustainable chemistry white biotechnology. Sources inspiration include current supply chain challenges, treasure enzymes, engineer tailor-made enzymes. Making best use power enzyme is essential changing products manufactured; renewable biobased replace fossil-based resources; improving safety, health, environmental aspects processes support cleaner more production.

Language: Английский

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Farmasötikler ve Ekosistem Üzerindeki Potansiyel Etkileri

European Journal of Engineering and Applied Sciences, Journal Year: 2024, Volume and Issue: 7(2), P. 114 - 118

Published: Dec. 31, 2024

Sağlık sektörü, insan sağlığı ve hayatıyla ilişkili temel faaliyet alanlarına bağlı olarak tüm dünyada en aktif, kapsamlı hızlı büyüyen sektörlerden birisidir. Günümüz dünyasında her geçen gün daha da önem kazanan genişleyen sektörün önemli çalışma konusu aynı zamanda bileşeni de olan farmasötiklerdir. Kullanım alanları amaçları ile ilgili çok farklı özelliklere sahip oldukça bir ürün grubunu temsil eden farmasötikler genel hastalıkların önlenmesi, teşhisi tedavisinde kullanılmak üzere biyolojik sistemlerle etkileşime girecek şekilde tasarlanan üretilen, karmaşık yapısal sahip, katma değeri yüksek kimyasallar tanımlanmaktadır. Ürünlerin fonksiyonları buna söz özellikleri, üretim süreçlerinin adımlı zorlu olmasına yol açmaktadır. Çoğunlukla doğal kaynaklar üzerinde oluşturdukları baskı yoğun kirletici etkileri karakteriz edilen prosesin nihai ürünleri farmasötikler, çevresel sürdürülebilirlik çalışmaları açısından büyük taşımaktadır. Bu durum ölçüde farmasötik kaynaklı kirliliğin sonrasında gerek ürünlerin kullanımı, gerekse kullanım dışı kalan formlarıyla devam etmesinden ileri gelmektedir. Doğrudan veya dolaylı pek kaynaktan çevreye yayılan günümüzde kalıcılıkları yayılma eğilimleri endişe verici yeni grubu kabul edilmektedir. çalışmada farmasötiklerin dahil oldukları sektörel yapı, üretim, özellikleri biyotransformasyon süreçleriyle birlikte ele alınarak değerlendirilmiştir.

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