Cited by The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders

Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception DOI

Achim Schilling, William Sedley, Richard Gerum

et al.

Brain, Journal Year: 2023, Volume and Issue: 146(12), P. 4809 - 4825

Published: July 27, 2023

Mechanistic insight is achieved only when experiments are employed to test formal or computational models. Furthermore, in analogy lesion studies, phantom perception may serve as a vehicle understand the fundamental processing principles underlying healthy auditory perception. With special focus on tinnitus-as prime example of perception-we review recent work at intersection artificial intelligence, psychology and neuroscience. In particular, we discuss why everyone with tinnitus suffers from (at least hidden) hearing loss, but not loss tinnitus. We argue that intrinsic neural noise generated amplified along pathway compensatory mechanism restore normal based adaptive stochastic resonance. The increase can then be misinterpreted input perceived This formalized Bayesian brain framework, where percept (posterior) assimilates prior prediction (brain's expectations) likelihood (bottom-up signal). A higher mean lower variance (i.e. enhanced precision) shifts posterior, evincing misinterpretation sensory evidence, which further confounded by plastic changes underwrite predictions. Hence, two provide most explanatory power for emergence perceptions: predictive coding top-down resonance complementary bottom-up mechanism. conclude both also play crucial role Finally, context neuroscience-inspired improve contemporary machine learning techniques.

Language: Английский

Citations

What is the safe noise exposure level to prevent noise-induced hearing loss? DOI

D J Fink

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2024, Volume and Issue: unknown

Published: April 18, 2024

Language: Английский

Citations

Plasticity of the auditory cortex and brainstem in surgically induced unilaterally deaf adult humans with and without tinnitus DOI

Minchul Park,

Greg A. O’Beirne,

Philip Bird

et al.

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

Auditory-nerve responses in mice with noise-induced cochlear synaptopathy DOI

Kirupa Suthakar, M. Charles Liberman

Journal of Neurophysiology, Journal Year: 2021, Volume and Issue: 126(6), P. 2027 - 2038

Published: Nov. 17, 2021

Noise-induced damage to synapses between inner hair cells and auditory-nerve fibers (ANFs) can occur without permanent cell damage, resulting in pathophysiology that “hides” behind normal thresholds. Prior single-fiber neurophysiology guinea pig suggested noise selectively targets high-threshold ANFs. Here, we show the lingering differs mouse, with both ANF groups affected a paradoxical gain-of-function surviving low-threshold fibers, including increased onset rate, decreased jitter, reduced maskability.

Language: Английский

Citations

Harnessing the power of artificial intelligence to transform hearing healthcare and research DOI

Nicholas A. Lesica, Nishchay Mehta,

Joseph Manjaly

et al.

Nature Machine Intelligence, Journal Year: 2021, Volume and Issue: 3(10), P. 840 - 849

Published: Oct. 18, 2021

Language: Английский

Citations

Intrinsic Noise Improves Speech Recognition in a Computational Model of the Auditory Pathway DOI

Achim Schilling, Richard Gerum, Claus Metzner

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 8, 2022

Noise is generally considered to harm information processing performance. However, in the context of stochastic resonance, noise has been shown improve signal detection weak sub- threshold signals, and it proposed that brain might actively exploit this phenomenon. Especially within auditory system, recent studies suggest intrinsic plays a key role even correspond increased spontaneous neuronal firing rates observed early stages stem cortex after hearing loss. Here we present computational model pathway based on deep neural network, trained speech recognition. We simulate different levels loss investigate effect noise. Remarkably, recognition actually improves with additional This surprising result indicates not only play crucial human processing, but be beneficial for contemporary machine learning approaches.

Language: Английский

Citations

What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus? DOI

Joel I. Berger, Alexander J. Billig, William Sedley

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(3)

Published: Feb. 15, 2024

Abstract The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus network by number studies. These structures are usually considered in the context “limbic system,” concept typically invoked to explain emotional response tinnitus. Despite this common framing, it is not apparent from current literature that necessarily main functional role these persistent Here, we highlight different encompasses their most commonly position within brain—that is, memory system. We consider an auditory object held memory, which may be made associated activity gyrus. Evidence animal human studies implicating reviewed used anchor for hypothesis. potential hippocampus/parahippocampal facilitate maintenance percept via communication with cortex, rather than (or addition to) mediating responses percept.

Language: Английский

Citations

Neural signatures of auditory hypersensitivity following acoustic trauma DOI

Matthew McGill, Ariel E. Hight,

Yurika Watanabe

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Sept. 16, 2022

Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations afferent activity levels. However, sudden peripheral deafferentation adulthood can trigger an excessive, non-homeostatic cortical compensatory response that may underlie perceptual disorders including hypersensitivity, phantom limb pain, and tinnitus. Here, we show mice with noise-induced damage of the high-frequency cochlear base were behaviorally hypersensitive spared mid-frequency tones direct optogenetic stimulation auditory thalamocortical neurons. Chronic two-photon calcium imaging from ACtx pyramidal neurons (PyrNs) revealed initial stage spatially diffuse hyperactivity, hyper-correlation, hyperresponsivity consolidated around deafferented map regions three or more days after acoustic trauma. Deafferented PyrN ensembles also displayed decoding mirrored behavioral suggesting regulation sound intensity coding following sensorineural loss be underlying source hypersensitivity. Excess gain trauma was expressed heterogeneously among individual PyrNs, yet 40% this variability could accounted for by each cell’s baseline properties prior PyrNs initially high spontaneous gradual monotonic growth functions likely excess This suggests while changes are triggered reduced bottom-up input, their subsequent stabilization is shaped local circuit milieu, where indicators inhibition presage pathological hyperactivity hearing loss.

Language: Английский

Citations

Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition DOI

Marlies Knipper, Wibke Singer, Kerstin Schwabe

et al.

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 15

Published: Jan. 6, 2022

Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory activity is associated with numerous forms of hearing loss, including noise damage, age-dependent and deafness, as well tinnitus or processing deficits autism spectrum disorder (ASD). In most cases, accompanying are interpreted an active compensatory response absence synaptic activity, increased neural gain control (increased output relative input). We here suggest that also could be related immaturity impairment tonic strength typically develops activity-dependent process ascending experience. these high-SR nerve fibers, which critical for shortest latencies lowest sound thresholds, may have either not matured (possibly congenital deafness autism) dysfunctional after sudden, stressful trauma loss cognitive decline). Fast can occur despite maintained basal hearing. case, nuclei, fast parvalbumin positive interneuron (PV-IN) dendrites diminished frontal brain regions. This leads hippocampal LTP/LTD deficiencies, deficits, unbalanced extra-hypothalamic stress control. Under conditions, a weaken local neuronal coupling homeostatic vascular responses required metabolic support adjustment processes. emphasize need distinguish two states excitatory/inhibitory imbalance disorders: (i) conditions preserved sustained strength, following deprivation maintain precise through memory linked, transient disinhibition enhanced spiking fidelity (central gain⇑) (ii) critically part synchronization over broader frequency range, reliability gain⇓). latter stage mutually reinforces processes, increasing risks canonical dementia syndromes.

Language: Английский

Citations

Hyperacusis and Tinnitus DOI

Martin Schecklmann, Laure Jacquemin, David Baguley

et al.

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 501 - 513

Published: Jan. 1, 2024

Language: Английский

Citations