Aphasia outcome: the interactions between initial severity, lesion size and location

Journal of Neurology, Journal Year: 2019, Volume and Issue: 266(6), P. 1303 - 1309

Published: Feb. 28, 2019

Language: Английский

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The utility of lesion classification in predicting language and treatment outcomes in chronic stroke-induced aphasia

Brain Imaging and Behavior, Journal Year: 2019, Volume and Issue: 13(6), P. 1510 - 1525

Published: May 15, 2019

Language: Английский

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Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy

Journal of Stroke, Journal Year: 2022, Volume and Issue: 24(2), P. 189 - 206

Published: May 31, 2022

Chronic aphasia, a devastating impairment of language, affects up to third stroke survivors. Speech and language therapy has consistently been shown improve function in prior clinical trials, but few clinicially applicable predictors individual response have identified date. Consequently, clinicians struggle substantially with prognostication the management aphasia. A rising prevalence particular younger populations, emphasized increasing demand for personalized approach aphasia therapy, that is, aimed at maximizing recovery each reference evidence-based recommendations. In this narrative review, we discuss current state literature respect commonly studied particular, focus our discussion on biographical, neuropsychological, neurobiological predictors, emphasize limitations literature, summarize consistent findings, consider how research field can better support development therapy. conclusion, review indicates future efforts should aim recruit larger samples people including by establishing multisite centers.

Language: Английский

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Atypical structural connectivity of language networks in autism spectrum disorder: A meta‐analysis of diffusion tensor imaging studies

Autism Research, Journal Year: 2022, Volume and Issue: 15(9), P. 1585 - 1602

Published: Aug. 13, 2022

Abstract Patients with autism spectrum disorder (ASD) often show pervasive and complex language impairments that are closely associated aberrant structural connectivity of networks. However, the characteristics white matter in ASD have remained inconclusive previous diffusion tensor imaging (DTI) studies. The current meta‐analysis aimed to comprehensively elucidate abnormality language‐related individuals ASD. We searched PubMed, Web Science, Scopus, Medline databases identify relevant standardized mean difference was calculated measure pooled DTI metrics each tract between typically developing (TD) groups. moderating effects age, sex, ability, symptom severity were investigated using subgroup meta‐regression analysis. Thirty‐three studies involving 831 836 TD controls included meta‐analysis. subjects showed significantly lower fractional anisotropy or higher diffusivity across language‐associated tracts than controls. These abnormalities tended be more prominent left networks right. In addition, children exhibit pronounced disturbances adults. results support under‐connectivity hypothesis demonstrate widespread abnormal microstructure patients Otherwise, autistic brain could vary depending on developmental stage hemisphere. Lay Summary This explored Significantly reduced integrity found all compared a leftward tendency, observed younger people

Language: Английский

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Neural mechanisms of two different verbal working memory tasks: A VLSM study

Neuropsychologia, Journal Year: 2018, Volume and Issue: 115, P. 25 - 41

Published: March 8, 2018

Language: Английский

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