Antiviral immunity triggered by infection-induced host transposable elements DOI Creative Commons
Benjamin G. Hale

Current Opinion in Virology, Journal Year: 2021, Volume and Issue: 52, P. 211 - 216

Published: Dec. 24, 2021

Host silencing of transposable elements (TEs) is critical to prevent genome damage and inappropriate inflammation. However, new evidence suggests that a virus-infected host may re-activate TEs co-opt them for antiviral defense. RNA-Seq specialized bioinformatics have revealed the diversity virus infections induce TEs. Furthermore, studies with influenza uncovered how infection-triggered changes SUMOylation TRIM28, an epigenetic co-repressor, lead TE de-repression. Importantly, there growing appreciation de-repressed stimulate gene expression, either via cis-acting enhancer functions or their recognition as viral mimetics by innate immune nucleic acid sensors (e.g. RIG-I, mda-5 cGAS). Understanding viruses trigger, counteract, TE-based immunity should provide insights into pathogenic mechanisms.

Language: Английский

A guide to cell death pathways DOI
Junying Yuan, Dimitry Ofengeim

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(5), P. 379 - 395

Published: Dec. 18, 2023

Language: Английский

Citations

299
Noncanonical DNA structures are drivers of genome evolution DOI Creative Commons
Kateryna D. Makova, Matthias H. Weissensteiner

Trends in Genetics, Journal Year: 2023, Volume and Issue: 39(2), P. 109 - 124

Published: Jan. 3, 2023

In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B DNA', can form in genomes across tree of life. Non-B regulates multiple cellular processes, including replication and transcription, yet its presence is associated with elevated mutagenicity genome instability. These discordant roles fuel enormous potential non-B drive genomic phenotypic evolution. Here we discuss recent studies establishing structures as novel functional elements subject natural selection, affecting evolution transposable (TEs), specifying centromeres. By highlighting contributions repeated adaptation changing environments, conclude that evolutionary analyses should include a perspective not only sequence, but also structure.

Language: Английский

Citations

60
SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses DOI Open Access
Shufen Li, Yulan Zhang,

Zhenqiong Guan

et al.

Cell Research, Journal Year: 2023, Volume and Issue: 33(3), P. 201 - 214

Published: Jan. 17, 2023

Language: Английский

Citations

52
A conserved family of immune effectors cleaves cellular ATP upon viral infection DOI Creative Commons
François Rousset, Erez Yirmiya,

Shahar Nesher

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(17), P. 3619 - 3631.e13

Published: Aug. 1, 2023

Language: Английский

Citations

49
Z‐Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis DOI Open Access

Sanchita Mishra,

Ayushi Amin Dey,

Sannula Kesavardhana

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 329(1)

Published: Jan. 1, 2025

ABSTRACT Z‐nucleic acid binding protein 1 (ZBP1) is an innate immune sensor recognizing nucleic acids in Z‐conformation. Upon sensing, ZBP1 triggers activation, inflammation, and programmed cell death during viral infections, mice development, inflammation‐associated diseases. The Zα domains of sense promote RIP‐homotypic interaction motif (RHIM)‐dependent signaling complex assembly to mount inflammation. studies on spurred understanding the role Z‐form RNA DNA cellular physiological functions. In particular, short genomic segments, endogenous retroviral elements, 3′UTR regions are likely sources Z‐RNAs that orchestrate Recent seminal identify intriguing association with adenosine deaminase acting RNA‐1 (ADAR1), cyclic GMP‐AMP synthase (cGAS) regulating aberrant chronic cancer. Thus, attractive target aid development specific therapeutic regimes for disease biology. Here, we discuss Z‐RNA activation death, Also, how coordinates intracellular perturbations homeostasis, formation regulate diseases

Language: Английский

Citations

2
Regulated cell death in cancer: from pathogenesis to treatment DOI Creative Commons
Linjing Gong, Dong Huang,

Yujun Shi

et al.

Chinese Medical Journal, Journal Year: 2022, Volume and Issue: 136(6), P. 653 - 665

Published: Aug. 10, 2022

Abstract Regulated cell death (RCD), including apoptosis, pyroptosis, necroptosis, and ferroptosis, is regulated by a series of evolutionarily conserved pathways, required for development tissue homeostasis. Based on previous genetic biochemical explorations subroutines, the characteristics each are generally considered distinctive. However, recent in-depth studies noted presence crosstalk between different forms RCD; hence, concept PANoptosis appeared. Cancer, complex disease, characterized stepwise deregulation apoptosis proliferation, with significant morbidity mortality globally. At present, RCD as well intricate relationships mainly focus infectious diseases, their roles in cancer remain unclear. As cancers dysregulated inflammatory responses, most current treatment strategies aim to selectively induce via pathways cells. In this review, we describe five types detail respect tumorigenesis progression. The potential value some these key effector molecules tumor diagnosis therapeutic response has also been raised. We then review highlight progress based ferroptosis induced small-molecule compounds, immune checkpoint inhibitors, nanoparticles. Together, findings may provide meaningful evidence fill gaps pathogenesis develop better strategies.

Language: Английский

Citations

54
ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host Immunity DOI Open Access
Hao Yu, Bo Yang,

Jinke Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10224 - 10224

Published: Sept. 6, 2022

Z-conformation nucleic acid binding protein 1 (ZBP1), a powerful innate immune sensor, has been identified as the important signaling initiation factor in response and multiple inflammatory cell death known PANoptosis. The of ZBP1 requires recognition left-handed double-helix Z-nucleic (includes Z-DNA Z-RNA) subsequent transduction depends on interaction between its adapter proteins, such TANK-binding kinase (TBK1), interferon regulatory 3 (IRF3), receptor-interacting serine/threonine-protein (RIPK1), RIPK3. activated immunity, including type-I (IFN-I) NF-κB signaling, constitutes an line defense against pathogenic infection. In addition, ZBP1-mediated PANoptosis is double-edged sword anti-infection, auto-inflammatory diseases, tumor immunity. beneficial for eliminating infected cells cells, but abnormal or excessive can lead to strong that harmful host. Thus, pathogens host have each developed multiplex tactics targeting maintain virulence homeostasis. this paper, we reviewed mechanisms effects immunity pathogen infection, various antagonistic strategies ZBP1. We also discuss existent gaps regarding forecast potential directions future research.

Language: Английский

Citations

44
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis DOI Creative Commons
Diego A. Rodríguez, Giovanni Quarato, Swantje Liedmann

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(41)

Published: Oct. 3, 2022

The absence of Caspase-8 or its adapter, Fas-associated death domain (FADD), results in activation receptor interacting protein kinase-3 (RIPK3)- and mixed-lineage kinase-like (MLKL)-dependent necroptosis vivo. Here, we show that spontaneous RIPK3, phosphorylation MLKL, Caspase-8- FADD-deficient cells was dependent on the nucleic acid sensor, Z-DNA binding protein-1 (ZBP1). We genetically engineered a mouse model by single insertion FLAG tag onto N terminus endogenous MLKL (

Language: Английский

Citations

43
Poxviruses and the immune system: Implications for monkeypox virus DOI Open Access
Amene Saghazadeh,

Nima Rezaei

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 113, P. 109364 - 109364

Published: Oct. 22, 2022

Language: Английский

Citations

39
Structure and Formation of Z-DNA and Z-RNA DOI Creative Commons
Jeffrey B. Krall, Parker J. Nichols, Morkos A. Henen

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(2), P. 843 - 843

Published: Jan. 14, 2023

Despite structural differences between the right-handed conformations of A-RNA and B-DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their similarities sequence preferences, RNA DNA exhibit in ability Z-conformation regarding hydration shells, chemical modifications that promote Z-conformation, structure junctions connecting them segments. this review, we highlight properties Z-DNA Z-RNA delve into potential factors contribute differences. While has been extensively studied, there is a gap knowledge when it comes Z-RNA. Where such information lacking, try extend principles stability formation Z-RNA, considering inherent acids.

Language: Английский

Citations

29