Cellular Sensors and Viral Countermeasures: A Molecular Arms Race between Host and SARS-CoV-2 DOI Creative Commons
Haoran Sun, Jasper Fuk‐Woo Chan, Shuofeng Yuan

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(2), P. 352 - 352

Published: Jan. 26, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of disease 2019 (COVID-19) pandemic that has caused disastrous effects on society and human health globally. SARS-CoV-2 a sarbecovirus in Coronaviridae family with positive-sense single-stranded RNA genome. It mainly replicates cytoplasm viral components including RNAs proteins can be sensed by pattern recognition receptors toll-like (TLRs), RIG-I-like (RLRs), NOD-like (NLRs) regulate host innate adaptive immune responses. On other hand, genome encodes multiple antagonize response to facilitate replication. In this review, we discuss current knowledge sensors countermeasures against provide insights virus–host interactions novel approaches modulate inflammation antiviral

Language: Английский

Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response DOI Creative Commons

Hend Jarras,

Isalie Blais,

Benjamin Goyer

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

The innate immune response is an important first checkpoint in the evolution of infection. Although adaptive immunity generally considered component that retains antigenic memory, responses can also be affected by previous stimulations. This study evaluated impact vaccination on cell activation TLR7/8 agonist R848, as well seasonal variations. To this end, blood samples from a cohort 304 food and retail workers Quebec City region were collected during three visits at 12-week intervals. Peripheral mononuclear cells polymorphonuclear neutrophils isolated third stimulated with R848 to assess response. Our results show IL-8 production after stimulation decreased vaccination. In addition, was significantly different depending season when visit occurred, for both COVID-19 vaccinated unvaccinated individuals. highlights SARS-CoV-2 fluctuate seasonally.

Language: Английский

Citations

0
Cytokine response against coronavirus DOI

Shobha Upreti,

Mukesh Samant, Nidhi Sharma

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 127 - 142

Published: Jan. 1, 2025

Citations

0
Morphopathology of the lesions induced by SARS-CoV-2 infection in the lungs DOI Open Access

Florin Ionuț Buibaș,

Roberta Andreea Cercel,

Mircea-Sebastian Șerbănescu

et al.

Romanian Journal of Morphology and Embryology, Journal Year: 2025, Volume and Issue: 65(4), P. 637 - 645

Published: Feb. 13, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spread rapidly from China around the world, causing worst pandemic since beginning of 21st century. Although disease named 2019 (COVID-19) has multiple organ symptoms, main pathological lesions occur in lung, failure, pulmonary embolism, secondary bacterial pneumonia and fibrosis. Despite best efforts researchers, pathogenesis SARS-CoV-2-induced cellular tissue damage organs systems is poorly understood. Therefore, our study, we aimed to highlight their extent, which could explain complex symptomatology presented by patients who died with distress (ARDS). The study was performed on a number 36 diagnosed COVID-19 under legally suspicious conditions, requiring autopsy within Romanian Forensic Medicine Institutes. All local inflammatory reaction pneumonic type, exudative proliferative phenomena, intra-alveolar interstitial infiltrates formed lymphocytes, macrophages neutrophilic granulocytes, congested or ruptured blood vessels hemorrhages, thrombosis, proliferation fibroblasts transformed into myofibroblasts presence granulation that remodeled entire lung parenchyma.

Language: Английский

Citations

0
Guardians at the gate: Unraveling Type I interferon’s role and challenges posed by anti-interferon antibodies in COVID-19 DOI
Alaa A. A. Aljabali, Mohammad A. Obeid,

Omar Gammoh

et al.

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 DOI Creative Commons

Anthony Flamier,

Punam Bisht,

Alexsia Richards

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(9), P. 107690 - 107690

Published: Aug. 19, 2023

COVID-19 has impacted billions of people since 2019 and unfolded a major healthcare crisis. With an increasing number deaths the emergence more transmissible variants, it is crucial to better understand biology disease-causing virus, SARS-CoV-2. Peripheral neuropathies appeared as specific symptom occurring at later stages disease. In order impact SARS-CoV-2 on peripheral nervous system, we generated human sensory neurons from induced pluripotent stem cells that infected with strain WA1/2020 variants delta omicron. Using single-cell RNA sequencing, found can be by but are unable produce infectious viruses. Our data indicate original well omicron yet infectability differs between variants.

Language: Английский

Citations

10
New insights into the pathogenesis of SARS-CoV-2 during and after the COVID-19 pandemic DOI Creative Commons

Jonatan J. Carvajal,

Valeria García-Castillo,

Shelsy V. Cuellar

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 7, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the distress condition known as COVID-19. This disease broadly affects several physiological systems, including gastrointestinal, renal, and central nervous (CNS) significantly influencing patient’s overall quality of life. Additionally, numerous risk factors have been suggested, gender, body weight, age, metabolic status, renal health, preexisting cardiomyopathies, inflammatory conditions. Despite advances in understanding genome pathophysiological ramifications COVID-19, its precise origins remain elusive. SARS-CoV-2 interacts with a receptor-binding domain within angiotensin-converting enzyme (ACE2). receptor expressed various organs different species, humans, abundance. Although COVID-19 has multiorgan manifestations, main pathologies occur lung, pulmonary fibrosis, failure, embolism, secondary bacterial pneumonia. In post-COVID-19 period, sequelae may occur, which causes, direct action virus, alteration immune response, alterations during infection, among others. Recognizing serious adverse health effects associated it becomes imperative to comprehensively elucidate discuss existing evidence surrounding this viral those related subsequent consequences. review aims contribute comprehensive impact long-term on human health.

Language: Английский

Citations

3
Vaccines against SARS-CoV-2 variants and future pandemics DOI
Taeyoung Park,

Hyogyeong Hwang,

Suhyeong Moon

et al.

Expert Review of Vaccines, Journal Year: 2022, Volume and Issue: 21(10), P. 1363 - 1376

Published: Aug. 4, 2022

Vaccination continues to be the most effective method for controlling COVID-19 infectious diseases. Nonetheless, SARS-CoV-2 variants continue evolve and emerge, resulting in significant public concerns worldwide, even after more than 2 years since pandemic. It is important better understand how different vaccine platforms work, why what options improving vaccines can considered fight against future pandemics.Here, we reviewed innate immune sensors recognition of virus, adaptive immunity including neutralizing antibodies by vaccines. Efficacy comparison several approved use humans, about breakthrough infections, developing COIVD-19 were also covered.Owing continuous emergence novel pathogens reemergence variants, safer new are needed. This review aims provide knowledge basis development next-generation pan-coronavirus cross-protection coronavirus pandemics.

Language: Английский

Citations

16
The immunogenetics of COVID-19 DOI Open Access
Anshika Srivastava,

Jill A. Hollenbach

Immunogenetics, Journal Year: 2022, Volume and Issue: 75(3), P. 309 - 320

Published: Dec. 19, 2022

Language: Английский

Citations

14
Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA–protein condensates DOI Creative Commons
Yongzhi Chen, Xuqiu Lei, Zhaozhao Jiang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(47)

Published: Nov. 14, 2023

A detailed understanding of the innate immune mechanisms involved in restricting SARS-CoV-2 infection and how virus disrupts these processes could reveal new strategies to boost antiviral develop therapeutics for COVID-19. Here, we identify cellular nucleic acid-binding protein (CNBP) as a key host factor controlling infection. In response RNA-sensing pathways, CNBP is phosphorylated translocates from cytosol nucleus where it binds interferon-β enhancer initiate transcription. Because evades detection by host’s largely retained restricts directly, leading battle between that extends beyond signaling pathways. We further demonstrated viral RNA directly competes with nucleocapsid prevent forming liquid–liquid phase separation (LLPS) condensates critical replication. Consequently, cells animals lacking have higher loads, CNBP-deficient mice succumb rapidly Altogether, findings SARS-CoV-2, functioning both regulator IFN gene expression cell-intrinsic restriction LLPS limit replication spread. addition, our studies also highlight important targets development drugs combat

Language: Английский

Citations

9
CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation DOI Open Access
Tamara Silva Rodrigues, Camila Carla da Silva Caetano, Keyla Santos Guedes de Sá

et al.

The Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 227(12), P. 1364 - 1375

Published: Feb. 10, 2023

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers activation of the NLRP3 inflammasome, which promotes inflammation and aggravates severe COVID-19. Here, we report that SARS-CoV-2 induces upregulation human caspase-4/CASP4 (mouse caspase-11/CASP11), this process contributes to activation. In vivo infections performed in transgenic hACE2 humanized mice, deficient or sufficient for Casp11, indicate Casp11−/− mice were protected from disease development, with increased pulmonary parenchymal area, reduced clinical score disease, mortality. Assessing samples fatal cases COVID-19, found CASP4 was expressed patient lungs correlated expression inflammasome components inflammatory mediators, including CASP1, IL1B, IL18, IL6. Collectively, our data establish CASP4/11 pathology, revealing a possible target therapeutic interventions

Language: Английский

Citations

8