Hepatitis C virus infection is associated with high risk of breast cancer: a pooled analysis of 68,014 participants DOI Creative Commons

Haiping Chen,

Pei Du,

Tianyao Yang

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Oct. 13, 2023

Breast cancer is the most common malignancy among women. Previous studies had shown that hepatitis C virus (HCV) infection might serve as a risk factor for breast cancer, while some failed to find such an association.In this study, we presented first attempt capture and clarify clinical debate via cumulative analysis (registration ID: CRD42023445888).After systematically searching excluding irrelevant publications, five case-control or cohort were finally included. The synthetic effect from eligible showed patients with HCV significantly higher prevalence of than non-HCV infected general population (combined HR= 1.382, 95%CI: 1.129 1.692, P=0.002). There was no evidence statistical heterogeneity during pooled (I2 = 13.2%, P=0.33). sensitivity analyses confirmed above findings. No significant publication bias observed included studies. underlying pathophysiological mechanisms relationship be associated persistent infection/inflammation, host immune response, modulation HCV-associated gene expression.Though causal association between did not seem quite strong, screening enable early detection help prevent progression disease. Since topic study remains matter debate, further are still warranted validate potential association.https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023445888.

Language: Английский

Current updates on the molecular and genetic signals as diagnostic and therapeutic targets for hepatitis B virus-associated hepatic malignancy DOI Creative Commons
Adane Adugna,

Yalew Muche,

Abateneh Melkamu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34288 - e34288

Published: July 1, 2024

Liver cancer caused by the hepatitis B virus (HBV) is third most common cancer-related cause of death worldwide. Early detection HBV-caused hepatic tumors increases likelihood a successful cure. Molecular and genetic signals are becoming more recognized as possible indicators HBV-associated malignancy how well treatment working. As result, we have discussed current literature on molecular sensors, including extracellular vesicle microRNAs (EV-miRNAs), long non-coding circulating RNAs (lncRNAs), vesicles (EVs), cell free DNA (cfDNA), for diagnosis forecasting HBV-related cancer. Extracellular such miR-335-5p, miR-172-5p, miR-1285-5p, miR-497-5p, miR-636, miR-187-5p, miR-223-3p, miR-21, miR-324-3p, miR-210-3p, miR-718, miR-122, miR-522, miR-0308-3p, miR-375 essential posttranscriptional regulation oncogenes in cells epigenetic modulation many internal external signaling pathways HBV-induced carcinogenesis. LncRNAs like lnc01977, HULC (highly up-regulated liver cancer), MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), HOTAIR (hox antisense intergenic RNA) been demonstrated to control hepatic-tumors growth, relocation, encroachment, resiliency. They also involved immune tracking, shifting, vasculature oversight, genomic destabilization. EVs critical mediators multiple aspects liver-tumors angiogenesis, immunology, tumor formation, dissemination malignant hepatocytes. Furthermore, cfDNA contributes associated with tumors, mutations abnormal changes during tumorigenesis.

Language: Английский

Citations

1
Rapid and Sensitive Digital Droplet PCR Assays for Detecting HPV16 DNA in Liquid Biopsies DOI Creative Commons
Suet Kee Loo, Jian Feng,

Carly Reeder

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 97(1)

Published: Dec. 29, 2024

ABSTRACT The combination of cell‐free DNA (cfDNA) and digital droplet PCR (ddPCR) has significantly advanced the noninvasive screening, diagnosis, monitoring diseases, enabling highly sensitive absolute quantification target nucleic acids even in presence high background DNA. However, widespread adoption ddPCR is hindered by higher costs, extended processing times, requirement for cfDNA purification, which adds expense variability. To address these limitations, we developed two optimized ddPCR‐based assays tailored enhanced sensitivity, cost‐efficiency, ease use. Our assay human papilloma virus (HPV)16 detection purified from liquid biopsies head neck cancer patients improved sensitivity increasing concentration 8.5‐fold, sample volume loading 22‐fold, total amount tested 1200‐fold without need restriction enzyme digestion. In parallel, established a rapid using unpurified processed heat treatment centrifugation, achieving concordance rates 55.6%, 66.7%, 95.8% plasma, serum, surgical drain fluid (SDF), respectively, compared to cfDNA. Together, complementary workflows, one other cfDNA, make specific targets more cost‐effective, time‐efficient, standardizable across laboratories, paving way broader clinical diagnostics.

Language: Английский

Citations

1
Serum-based studies show novel biomarkers for circulating HPV-DNA in high-risk HPV women as a biomarker for early detection of cervical cancer. DOI Creative Commons

Venkatesh,

Jadeppa Gowda,

A. Bs

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Abstract Background: Cervical cancer caused by HPV is the fourth most common in women worldwide. Detecting circulating cell-free HPV-DNA can provide valuable information about treatment response as well serve a diagnostic and prognostic tool for residual disease relapse. However, only few biomarkers are available early diagnosis, current ones require tissue excision or invasive procedures, limiting their use routine diagnosis. Analysis of nucleic acids has become popular newly reported biomarker identifying individuals with cancer. In recent study, was successfully detected 85% treatment-naive patients, changes levels corresponding to relapse were observed. shows promise therapy monitoring both primary recurrent cervical cancer, it could sensitive, non-invasive, easily accessible diagnosis follow-up.

Language: Английский

Citations

0
Editorial overview: Viruses and Cancer DOI
Ethel Cesarman, Jennifer Totonchy

Current Opinion in Virology, Journal Year: 2023, Volume and Issue: 62, P. 101364 - 101364

Published: Sept. 5, 2023

Language: Английский

Citations

0
Hepatitis C virus infection is associated with high risk of breast cancer: a pooled analysis of 68,014 participants DOI Creative Commons

Haiping Chen,

Pei Du,

Tianyao Yang

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Oct. 13, 2023

Breast cancer is the most common malignancy among women. Previous studies had shown that hepatitis C virus (HCV) infection might serve as a risk factor for breast cancer, while some failed to find such an association.In this study, we presented first attempt capture and clarify clinical debate via cumulative analysis (registration ID: CRD42023445888).After systematically searching excluding irrelevant publications, five case-control or cohort were finally included. The synthetic effect from eligible showed patients with HCV significantly higher prevalence of than non-HCV infected general population (combined HR= 1.382, 95%CI: 1.129 1.692, P=0.002). There was no evidence statistical heterogeneity during pooled (I2 = 13.2%, P=0.33). sensitivity analyses confirmed above findings. No significant publication bias observed included studies. underlying pathophysiological mechanisms relationship be associated persistent infection/inflammation, host immune response, modulation HCV-associated gene expression.Though causal association between did not seem quite strong, screening enable early detection help prevent progression disease. Since topic study remains matter debate, further are still warranted validate potential association.https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023445888.

Language: Английский

Citations

0